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SUMO4 M55V Variant Is Associated with Diabetic Nephropathy in Type 2 Diabetes

¹Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
²Graduate Institute of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan
³Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
⁴Division of Endocrinology and Metabolism, E-Da Hospital, Kaohsiung, Taiwan

Correspondence: sjshin{at}kmu.edu.tw

Key Words: SUMO4 • NF-B • diabetic nephropathy • albuminuria

OBJECTIVE: SUMO4 mRNA is recently found to be mainly expressed in the kidney and M55V variant of SUMO4 may induce higher NF-B activity. Because NF-B is known to mediate the development of diabetic nephropathy, we examined the association between SUMO4 M55V variant and the severity of diabetic nephropathy.

RESEARCH DESIGN AND METHODS: We recruited a total of 430 patients with type 2 diabetes. The M55V (rs237025, 163A>G) polymorphism of SUMO4 was genotyped by real time-PCR and urine albumin concentration was measured by radioimmunoassay.

RESULTS: The frequencies of SUMO4 AA, GA and GG were 52.6%, 40.7% and 6.7% in the normoalbuminuric group; 45.5%, 47.3% and 7.1% in the microalbuminuric group; 36.9%, 46.2% and 16.9% in the macroalbuminuric group, respectively. We detected a significant linear trend for SUMO4 genotype betwen macroalbeuminuric and normoalbuminuric group. The mean urine albumin/creatinine ratio (42.3 ±108.82 mg/mmol) in GG group was significantly higher than in AA (14.9±51.49 mg/mmol) and in GA (17.0 ± 43.74 mg/mmol) groups. Multivariate logistic regression analysis showed SUMO4 M55V variant to be independently associated with the severity of diabetic nephropathy.

CONCLUSIONS: This study indicates that the SUMO4 gene M55V variant is associated with the severity of diabetic nephropathy in patients with type 2 diabetes.

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This article has been cited by other articles:

				G. Rudofsky Jr., A. Schlotterer, P. P. Nawroth, A. Bierhaus, and A. Hamann Comment on: Lin et al. (2007) SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Diabetes 56:1177 1180 Diabetes, August 1, 2007; 56(8): e11 - e11. [Full Text] [PDF]

				S.-J. Shin, H.-Y. Lin, C.-L. Wang, P.-J. Hsiao, and K.-D. Lin Response to Comment on: Lin et al. (2007) SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Diabetes 56:1177 1180 Diabetes, August 1, 2007; 56(8): e12 - e13. [Full Text] [PDF]