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Diabetes Publish Ahead of Print published online ahead of print April 6, 2007
DOI: 10.2337/db06-1329
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Original Research

QTLs for fasting glucose in young Europeans replicate previous findings for type 2 diabetes in 2q23-24 and other locations.

Delphine Fradin1,2,3, Simon Heath2, Mark Lathrop2, and Pierre Bougnères1

1Hôpital Saint-Vincent de Pau,l Department of Pediatric Endocrinology and U561 - Institut National de la Santé et de la Recherche Médicale, Paris, France
2Centre National de Génotypage, Evry, France
3Equipe d'Accueil University Paris V, Paris, France

Correspondence: fradin{at}paris5.inserm.fr

Long before reaching diagnostic cut off levels for type 2 diabetes (T2D), fasting glucose can be a powerful risk marker for this disease. We conducted a genome-wide search for fasting glucose as a quantitative trait in 412 young Europeans sib-pairs including obese children, with adjustment for sex, age and BMI. We identified more QTLs specific of fasting glucose and more significant than would be found by simple chance estimated by permutation tests. The strongest linkage was on chromosome 2q (LOD=3.00) in a region previously linked to T2D as a disease. We also found linkage signals of fasting glucose with 7q (LOD=2.03), 8q (LOD=1.28), 17p (LOD=2.12), 17q (LOD=1.4) et 11p (LOD=1.33). These findings suggest that the quantitative genetics of fasting glucose could contribute to the search for T2D genes.


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Copyright © 2007 by the American Diabetes Association.