Circulating Levels of Endothelial Adhesion Molecules and Risk of Diabetes Mellitus in an Ethnically Diverse Cohort of Women

doi:10.2337/db07-0250

HOME

HELP

FEEDBACK

SUBSCRIPTIONS

Original Research

Circulating Levels of Endothelial Adhesion Molecules and Risk of Diabetes Mellitus in an Ethnically Diverse Cohort of Women

Yiqing Song, MD, ScD¹, JoAnn E. Manson, MD, DrPH¹^,2^,3, Lesley Tinker, PhD, RD⁴, Nader Rifai, PhD⁵, Nancy R. Cook, ScD¹^,3, Frank B. Hu, MD, PhD²^,3, Gokhan S. Hotamisligil, MD, PhD⁶, Paul M. Ridker, MD, MPH¹, Beatriz L. Rodriguez, MD, PhD⁷, Karen L. Margolis, MD, MPH⁸, Albert Oberman, MD, MPH⁹, and Simin Liu, MD, ScD¹^,3^,10

¹Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston
²Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston
³Department of Epidemiology, Harvard School of Public Health, Boston
⁴Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Children's Hospital, Harvard Medical School, Boston
⁶Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston
⁷Department of Public Health Sciences and Epidemiology and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, and Pacific Health Research Institute, Honolulu
⁸HealthPartners Research Foundation, Minneapolis
⁹The Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham
¹⁰Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA

OBJECTIVE:: Elevated circulating levels of soluble adhesion molecules asmarkers of endothelial dysfunction have been related to insulinresistance and its associated metabolic abnormalities. However,their associations with type 2 diabetes remain inconclusive.

RESEARCH DESIGN AND METHODS:: We conducted a prospective nested case-control study to examinethe associations between plasma levels of E-selectin, intercellularadhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1(VCAM-1) and diabetes risk among 82,069 initially healthy womenaged 50 to 79 years from the Women's Health Initiative ObservationalStudy. During a median follow-up of 5.9 years, 1,584 incidentdiabetes cases were matched with 2,198 controls by age, ethnicity,clinical center, time of blood draw, and follow-up time.

RESULTS:: Baseline median levels of the biomarkers were each significantlyhigher among cases than among controls (E-selectin, 49 versus37 ng/mL; ICAM-1, 324 versus 280 ng/mL; VCAM-1, 765 versus 696ng/mL [all P values <0.001]). After adjustment for risk factors,the relative risks of diabetes among women in the highest quartileversus those in the lowest quartile were 3.46 for E-selectin(95 percent confidence interval [95% CI], 2.56 to 4.68; P fortrend <0.0001), 2.34 for ICAM-1 (95% CI, 1.75 to 3.13; Pfor trend <0.0001), and 1.48 for VCAM-1 (95% CI, 1.07 to2.04; P for trend =0.009). E-selectin and ICAM-1 remains significantin each ethnic group.

CONCLUSIONS:: Higher levels of E-selectin and ICAM-1 were consistently associatedwith increased diabetes risk in a multiethnic cohort of US postmenopausalwomen, implicating an etiologic role of endothelial dysfunctionin the pathogenesis of type 2 diabetes.

CiteULike

Del.icio.us Add to Digg

Digg

Technorati What's this?

This article has been cited by other articles:

E. L. Ding and F. B. Hu
Smoking and Type 2 Diabetes: Underrecognized Risks and Disease Burden
JAMA, December 12, 2007; 298(22): 2675 - 2676.
[Full Text] [PDF]

Y. Song and S. Liu
Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women: the Women's Health Initiative Observational Study: Response to Boyko et al.
Diabetes Care, November 1, 2007; 30(11): e111 - e111.
[Full Text] [PDF]