HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Online-Only Appendix All Versions of this Article: db07-0482v1 56/12/3033    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hayes, M. G. Articles by Hanis, C. L. Search for Related Content PubMed PubMed Citation Articles by Hayes, M. G. Articles by Hanis, C. L. Social Bookmarking                What's this?

Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-wide Association Studies

¹ Department of Medicine, The University of Chicago, Chicago, IL
² Department of Human Genetics, The University of Chicago, Chicago, IL
³ Human Genetics Center, The University of Texas Health Sciences Center, Houston, TX

OBJECTIVE: To identify DNA polymorphisms associated with type 2 diabetes (T2D) in a Mexican American (MA) population.

RESEARCH DESIGN AND METHODS: We genotyped 116,204 single nucleotide polymorphisms (SNPs) in 281 MA with T2D and 280 random MA from Starr County, Texas using the Affymetrix GeneChip® Human Mapping 100K Set. Allelic association exact tests were calculated. Our most significant SNPs were compared to results from other T2D genome-wide association studies (GWAS). Proportions of African, European, and Asian ancestry were estimated from the HapMap samples using structure for each individual to rule out spurious association due to population substructure.

RESULTS: We observed more significant allelic associations than expected genome-wide as empirically assessed by permutation [14 below a p of 1x10^-4 (8.7 expected)]. No significant differences were observed between the proportion of ancestry estimates in the case and random control sets suggesting the association results were not likely confounded by substructure. A query of our top 1% of SNPs (p<0.01) revealed SNPs in or near four genes that showed evidence for association (p<0.05) in multiple other GWAS interrogated: rs979752 and rs10500641 near UBQLNL and OR52H1 on chromosome 11, rs2773080 and rs3922812 in or near RALGPS2 on chromosome 1, and rs1509957 near EGR2 on chromosome 10.

CONCLUSIONS: We identified several SNPs with suggestive evidence for replicated association with T2D which merit further investigation.

Abbreviations:

Correspondence: Craig.L.Hanis{at}uth.tmc.edu

CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. S. Rich, J. M. Norris, and J. I. Rotter Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association Scan: As a Trickle Becomes a Flood Diabetes, November 1, 2008; 57(11): 2915 - 2917. [Full Text] [PDF]

				K. J. Gaulton, C. J. Willer, Y. Li, L. J. Scott, K. N. Conneely, A. U. Jackson, W. L. Duren, P. S. Chines, N. Narisu, L. L. Bonnycastle, et al. Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes Diabetes, November 1, 2008; 57(11): 3136 - 3144. [Abstract] [Full Text] [PDF]

				K. D. Taylor, J. M. Norris, and J. I. Rotter Genome-Wide Association: Which Do You Want First: the Good News, the Bad News, or the Good News? Diabetes, December 1, 2007; 56(12): 2844 - 2848. [Full Text] [PDF]

				E. Rampersaud, C. M. Damcott, M. Fu, H. Shen, P. McArdle, X. Shi, J. Shelton, J. Yin, Y.-P. C. Chang, S. H. Ott, et al. Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish: Evidence for Replication From Diabetes-Related Quantitative Traits and From Independent Populations Diabetes, December 1, 2007; 56(12): 3053 - 3062. [Abstract] [Full Text] [PDF]

				R. L. Hanson, C. Bogardus, D. Duggan, S. Kobes, M. Knowlton, A. M. Infante, L. Marovich, D. Benitez, L. J. Baier, and W. C. Knowler A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array Diabetes, December 1, 2007; 56(12): 3045 - 3052. [Abstract] [Full Text] [PDF]

				J. C. Florez, A. K. Manning, J. Dupuis, J. McAteer, K. Irenze, L. Gianniny, D. B. Mirel, C. S. Fox, L. A. Cupples, and J. B. Meigs A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study: Replication and Integration With Other Genome-Wide Datasets Diabetes, December 1, 2007; 56(12): 3063 - 3074. [Abstract] [Full Text] [PDF]