Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Diabetes Publish Ahead of Print published online ahead of print August 23, 2007
DOI: 10.2337/db07-0768
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
db07-0768v1
56/12/2849    most recent
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Meer, R. W.
Right arrow Articles by Lamb, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Meer, R. W.
Right arrow Articles by Lamb, H. J.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Original Research

Short term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects

Rutger W. van der Meer, MD1,,2, Sebastiaan Hammer2, Johannes W.A. Smit, MD, PhD2, Marijke Frölich, PhD3, Jeroen J. Bax, MD, PhD4, Michaela Diamant, MD, PhD5, Luuk J. Rijzewijk, MD5, Albert de Roos, MD, PhD1, Johannes A. Romijn, MD, PhD2, and Hildo J. Lamb, MD, PhD1

1Department of Radiology,
2Endocrinology,
3Clinical Chemistry,
4Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
5Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.

Correspondence: R.W.van_der_meer{at}lumc.nl

Objective: Diabetes mellitus and obesity are associated with increased plasma non-esterified fatty acid (NEFA) levels, myocardial triglyceride accumulation and myocardial dysfunction. Because a very low calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride (TG) content and cardiac function in healthy subjects.

Research Design and Methods: Fourteen healthy non-obese men underwent 1H-magnetic resonance spectroscopy (MRS) to determine myocardial and hepatic triglyceride content, 31P-MRS to assess myocardial high-energy-phosphate metabolism (PCr/ATP), and MR imaging of myocardial function at baseline and after a 3-day VLCD.

Results: After the dietary intervention, plasma NEFA levels increased compared to baseline (from 0.5 ± 0.1 to 1.1 ± 0.1mmol/l, p< 0.05). Concomitantly, myocardial TG content increased by ~55%, compared to baseline (from 0.38 ± 0.05 to 0.59 ± 0.06%, p< 0.05), whereas liver TG content decreased by ~32% (from 2.2 ± 0.5 to 1.5 ± 0.4%, p< 0.05). The VLCD did not change myocardial PCr/ATP (2.33 ± 0.15 vs. 2.33 ± 0.08, p> 0.05) or systolic function. Interestingly, deceleration of the early diastolic flow across the mitral valve decreased after the VLCD (from 3.37 ± 0.20 to 2.91 ± 0.16ml/s2 x 10-3, p< 0.05). This decrease in diastolic function was significantly correlated with the increase in myocardial TG content.

Conclusions: Short-term VLCD induces accumulation of myocardial TG. In addition, VLCD decreases left ventricular diastolic function, without alterations in myocardial high-energy-phosphate metabolism. This study documents diet dependent, physiological variations in myocardial TG content and diastolic function in healthy subjects.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2007 by the American Diabetes Association.