Pancreatic Perinuclear Inclusions in Diabetes Mellitus and Other Diseases

  1. Gene Thomas, BS
  1. Department of Pathology, Washington University School of Medicine St. Louis, Missouri 63110


Unusual perinuclear inclusions in pancreatic duct cells were observed by electron microscopy in 23 diabetic pancreases, in nine pancreases with islet hyperplasia, and in 10 of 27 pancreases without islet pathology. The origin and significance of the perinuclear inclusions could not be determined, but it is suggested that they may be of viral origin or may represent a cellular response to an unknown stimulus.

  • Accepted March 22, 1977.
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