The effect of donor strain blood and ALS therapy on pancreatic islet allograft survival in the rat.
- H P Selawry,
- H L Cohen and
- M M Mui
Abstract
Small amounts of donor strain ACI blood injected in conjunction with minimal ALS therapy prolonged islet allograft survival in Wistar-Lewis, diabetic recipients from a mean of 8 days in nontransfused rats to a mean of more than 100 days. ACI skin grafts transplanted on long-surviving transplant-improved rats were rejected within 8 days, which suggested that "classical" tolerance was probably not the mechanism responsible for the blood-induced suppression of islet allograft rejection.
