Selective Extravascular Escape of Albumin into the Cerebral Cortex of the Diabetic Rat
- Departments of Physiology and Anatomy, School of Medicine, West Virginia University Morgantown, West Virginia 26506
- Address reprint requests to William T. Stauber at the above address.
The extravasation of plasma proteins (albumin, IgG, and complement C3) into the cerebral cortex was studied in streptozotocin-induced diabetic rats using im-munohistochemical techniques. The results indicate that albumin, but not IgG or complement C3, selectively enters the cerebral cortex within 2 wk after induction of diabetes. It is suggested that albumin may be an oncotic substance that contributes to diabetic cerebral microangiopathy, astrocytic swelling, and the cerebral edema that occasionally is seen during fluid and insulin therapy of juvenile ketoacidotic diabetes.
- Received June 11, 1980.
- Revision received February 10, 1981.
- Copyright © 1981 by the American Diabetes Association