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Original Contributions

HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus

  1. Takehiko Sakurami,
  2. Yukio Ueno,
  3. Kengo Nagaoka,
  4. Shotaro Kuno,
  5. Yuichi Iwaki,
  6. Min S Park and
  7. Paul I Terasaki
  1. Second Division of Internal Medicine, Faculty of Medicine, Kyoto University Kyoto, Japan
  2. Department of Internal Medicine, Osaka Red Cross Hospital Osaka, Japan
  3. Department of Surgery, UCLA School of Medicine, University of California Los Angeles, California
  1. Address reprint requests to Dr. Yuichi Iwaki, Department of Surgery, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, California 90024.
Diabetes 1982 Feb; 31(2): 105-106. https://doi.org/10.2337/diab.31.2.105
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Abstract

Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the frequency of HLA-DR4 was found in patients but not in unaffected persons: DR4 was found in 56.3% of the patients versus 32.6% of the unaffected persons. However, the negative correlation between DR2 and patients was not statistically significant.

  • Received November 17, 1980.
  • Revision received August 19, 1981.
  • Accepted August 19, 1981.
  • Copyright © 1982 by the American Diabetes Association

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February 1982, 31(2)
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HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus
Takehiko Sakurami, Yukio Ueno, Kengo Nagaoka, Shotaro Kuno, Yuichi Iwaki, Min S Park, Paul I Terasaki
Diabetes Feb 1982, 31 (2) 105-106; DOI: 10.2337/diab.31.2.105

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HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus
Takehiko Sakurami, Yukio Ueno, Kengo Nagaoka, Shotaro Kuno, Yuichi Iwaki, Min S Park, Paul I Terasaki
Diabetes Feb 1982, 31 (2) 105-106; DOI: 10.2337/diab.31.2.105
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