HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus

Takehiko Sakurami; Yukio Ueno; Kengo Nagaoka; Shotaro Kuno; Yuichi Iwaki; Min S Park; Paul I Terasaki

doi:10.2337/diab.31.2.105

Original Contributions

HLA-DR Specifications in Japanese with Juvenile-onset Insulin-Dependent Diabetes Mellitus

Takehiko Sakurami,
Yukio Ueno,
Kengo Nagaoka,
Shotaro Kuno,
Yuichi Iwaki,
Min S Park and
Paul I Terasaki

Second Division of Internal Medicine, Faculty of Medicine, Kyoto University Kyoto, Japan
Department of Internal Medicine, Osaka Red Cross Hospital Osaka, Japan
Department of Surgery, UCLA School of Medicine, University of California Los Angeles, California

Address reprint requests to Dr. Yuichi Iwaki, Department of Surgery, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, California 90024.

Diabetes 1982 Feb; 31(2): 105-106. https://doi.org/10.2337/diab.31.2.105

Abstract

Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the frequency of HLA-DR4 was found in patients but not in unaffected persons: DR4 was found in 56.3% of the patients versus 32.6% of the unaffected persons. However, the negative correlation between DR2 and patients was not statistically significant.