Is Somatostatin a True Local Inhibitory Regulator of Insulin Secretion?

  1. H Horie
  1. Department of Internal Medicine and the First Department of Pathology (H. H.), Chiba University School of Medicine Chiba 280, Japan
  1. Address reprint requests to Azuma Kanatsuka, M.D., Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan.

Abstract

Pancreatic somatostatin was depleted after oral administration of cysteamine to rats, yet the B-cells in the isolated islets were morphologically and functionally intact. Compared with islets from the rats not given cysteamine, the somatostatin-depleted islets released larger amounts of insulin during 1 h of incubation by glucose or 3-isobutyl-1-methylxanthine stimulation. Therefore, the possibility that pancreatic somatostatin may locally regulate the inhibitory effects of insulin secretion has to be considered.

  • Received July 19, 1983.
  • Revision received November 10, 1983.
  • Accepted November 10, 1983.
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