Decreased Synthesis of Interleukin-2 (IL-2) in Insulin-dependent Diabetes Mellitus
- Children's Cancer Research Center, Division of Allergy, Immunology and Bone Marrow Transplantation; and the Division of Endocrinology, Departments of Pediatrics and Human Genetics, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
- Address reprint requests to Dr. Karen Zler, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, Pennsylvania 19104.
Synthesis of interleukin-2 (IL-2) by lymphocytes from 26 insulin-dependent diabetic subjects (IDDM) was compared with that by lymphocytes from 24 nondiabetic control subjects. The control group produced 1.001 ± 0.071 U/ml (mean ± SEM). The IDDM group, containing patients diagnosed between 5 days and 10 yr before testing, produced only 0.59 ± 0.050 U/ml (P < 0.002). IL-2 synthesis by 6 non-insulin-dependent diabetic subjects (NIDDM) was not decreased (mean ± SEM, 1.20 ± 0.04 U/ml). Moreover, decreased levels of IL-2 production was found with lymphocytes of patients in good control, as well as those in poor control. These data suggest that decreased IL-2 synthesis is specific for IDDM, not explainable solely as a consequence of poor metabolic control, and thus, might be involved in the pathogenesis of the disease.
- Received February 28, 1983.
- Revision received November 15, 1983.
- Accepted November 15, 1983.
- Copyright © 1984 by the American Diabetes Association