We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.
- Received August 10, 1987.
- Revision received October 19, 1987.
- Accepted October 19, 1987.
- Copyright © 1988 by the American Diabetes Association