Reduction of Glycemic and Lipid Levels in db/db Diabetic Mice by Psyllium Plant Fiber

  1. Peter Blaisdell
  1. Division of Health and Personal Care, the Procter and Gamble Corporation Cincinnati Ohio
  1. Address correspondence and reprint requests to Dr. Karen Watters, Division of Health and Personal Care, the Procter and Gamble Corporation, 11511 Reed Hartman Highway, The 790 Building, Biological Efficacy Test Facility, Cincinnati, OH 45241.

Abstract

The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the animal model. High-density lipoprotein cholesterol levels rose moderately in both psyllium- and placebo-fed animals during the study, whereas triglyceride levels remained unchanged in both groups. Psyllium's effect on glycemic, lipid, and hormone parameters was not explained by weight loss or reduced food intake; these were similar in psyllium- and placebo-fed animals during the study. Our results show that psyllium fiber can beneficially moderate glycemic and lipid parameters in the db/db diabetes model.

  • Received February 20, 1989.
  • Revision received August 3, 1989.
  • Accepted August 3, 1989.
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