Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

  1. C. Ronald Kahn
  1. Joslin Diabetes Center and the Department of Medicine, Harvard Medical School Boston, Massachusetts
  1. Address correspondence and reprint requests to Dr. C. Ronald Kahn, Joslin Diabetes Center, Room 620, One Joslin Place, Boston, MA 02215.


The person who passes urine which is exceedingly sweet, cool, slightly viscid, turbid, and resembling the juices of the sugarcane … suffers from glycosuria. … There are two types of urinary disorders—one, natural due to genetic factors, and the other due to indiscreet living or dietetic indiscretions. The patient suffering from the former is thin, pale, eats less and drinks too much.… The patient with the latter is usually obese, eats a lot, is stout, of sedentary habits and sleeps too much.

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