Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Manage Online Access
    • Individual Subscriptions
    • Institutional Subscriptions
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcast
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
Diabetes
Advertisement
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Manage Online Access
    • Individual Subscriptions
    • Institutional Subscriptions
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcast
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Task Force Report

Report of the American Diabetes Association's Task Force on Standardization of the Insulin Assay

  1. David C Robbins, chair,
  2. Lennart Andersen,
  3. Ron Bowsher,
  4. Ron Chance,
  5. Bo Dinesen,
  6. Bruce Frank,
  7. Ron Gingerich,
  8. David Goldstein,
  9. Hsaio-Mei Widemeyer,
  10. Steven Haffner,
  11. C Nick Hales,
  12. Leonard Jarett,
  13. Kenneth Polonsky,
  14. Daniel Porte,
  15. Jay Skyler,
  16. George Webb and
  17. Kathy Gallagher
  1. Novo Nordisk Laboratories, Novo Nordisk A/S Bagsvaerd
  2. Steno Diabetes Center Gentofte, Denmark
  3. Lilly Research Laboratories, Eli Lilly Indianapolis, Indiana
  4. Department of Pediatrics, University of Missouri Columbia
  5. Linco Research St. Louis, Missouri
  6. University of Texas Health Sciences Center San Antonio, Texas
  7. Cambridge University Cambridge, U.K.
  8. Department of Pathology, University of Pennsylvania Philadelphia, Pennsylvania
  9. Department of Medicine, University of Chicago Hospital and Clinics Chicago, Illinois
  10. Department of Medicine, University of Washington Seattle, Washington
  11. Department of Medicine, University of Miami Miami, Florida
  12. Penn Medical Laboratory, Medlantic Research Institute Washington, DC
  1. Address correspondence and reprint requests to Dr. David C. Robbins, Medlantic Research Institute, 108 Irving St. NW, Washington, DC 20010.
Diabetes 1996 Feb; 45(2): 242-256. https://doi.org/10.2337/diab.45.2.242
PreviousNext
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Recent large-scale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict the development of NIDDM and IDDM and are associated with the risk of several degenerative diseases, such as coronary and peripheral vessel atherosclerosis, hypertension, and dyslipidemia. The reliability of these measurements is dependent on a biological assay that has not been well standardized between laboratories. Recognizing this, the American Diabetes Association organized a task force to assess comparability of blood insulin measurements between laboratories and to suggest techniques to improve comparability. The task force found that identical serum and plasma samples measured in different laboratories produced widely disparate values that were unacceptable for population comparisons. Use of a single reference standard did little to improve comparability. Assay characteristics such as linearity, recovery, accuracy, and cross-reactivity to proinsulin and its primary conversion intermediates varied among the laboratories, and they did not readily explain differences in the measurements made from assay to assay. Use of the same assay kit in different laboratories did not always ensure comparable measurements. Linear regression of assay results from one laboratory to an arbitrarily chosen reference assay greatly improved comparability and demonstrated the potential value in comparing each assay to a reference method. The task force report defines acceptable assay characteristics and proposes a three-step process of insulin assay proficiency and comparability. A central reference assay and ongoing sample exchange will be needed to allow reliable comparisons of insulin measurements made in different laboratories. Rigorous quality control and continuous quality improvement are needed to maintain reliability of the insulin measurement.

  • Copyright © 1996 by the American Diabetes Association

Log in using your username and password

Forgot your user name or password?

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

PreviousNext
Back to top
Advertisement

In this Issue

February 1996, 45(2)
  • Table of Contents
  • Index by Author
Sign up to receive current issue alerts
View Selected Citations (0)
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Report of the American Diabetes Association's Task Force on Standardization of the Insulin Assay
(Your Name) has forwarded a page to you from Diabetes
(Your Name) thought you would like to see this page from the Diabetes web site.
Citation Tools
Report of the American Diabetes Association's Task Force on Standardization of the Insulin Assay
David C Robbins, Lennart Andersen, Ron Bowsher, Ron Chance, Bo Dinesen, Bruce Frank, Ron Gingerich, David Goldstein, Hsaio-Mei Widemeyer, Steven Haffner, C Nick Hales, Leonard Jarett, Kenneth Polonsky, Daniel Porte, Jay Skyler, George Webb, Kathy Gallagher
Diabetes Feb 1996, 45 (2) 242-256; DOI: 10.2337/diab.45.2.242

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Report of the American Diabetes Association's Task Force on Standardization of the Insulin Assay
David C Robbins, Lennart Andersen, Ron Bowsher, Ron Chance, Bo Dinesen, Bruce Frank, Ron Gingerich, David Goldstein, Hsaio-Mei Widemeyer, Steven Haffner, C Nick Hales, Leonard Jarett, Kenneth Polonsky, Daniel Porte, Jay Skyler, George Webb, Kathy Gallagher
Diabetes Feb 1996, 45 (2) 242-256; DOI: 10.2337/diab.45.2.242
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

Similar Articles

Navigate

  • Current Issue
  • Online Ahead of Print
  • Scientific Sessions Abstracts
  • Collections
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • For Advertisers
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes Care
  • Clinical Diabetes
  • Diabetes Spectrum
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Scientific Sessions Abstracts
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org
Advertisement

© 2019 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.