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Original Articles

Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats

  1. Robin E Buckingham,
  2. Kamal A Al-Barazanji,
  3. C D Nigel Toseland,
  4. Mark Slaughter,
  5. Susan C Connor,
  6. Andrew West,
  7. Brian Bond,
  8. Nicholas C Turner and
  9. John C Clapham
  1. SmithKline Beecham Pharmaceuticals The Frythe, Welwyn, Herts, U.K.
  2. Harlow, Essex and SmithKline Beecham Pharmaceuticals The Frythe, Welwyn, Herts, U.K.
  1. Address correspondence and reprint requests to Dr. Robin Buckingham, Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Third Ave., Harlow, Essex, CM19 5AW, U.K.
Diabetes 1998 Aug; 47(8): 1326-1334. https://doi.org/10.2337/diab.47.8.1326
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Abstract

Rosiglitazone (BRL 49653), a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist and potent insulin action-enhancing agent, was given in the diet (50 umol/kg of diet) to male Zucker rats ages 6–7 weeks for 9 months (prevention group). In this treatment mode, rosiglitazone prolonged the time to onset of proteinuria from 3 to 6 months and markedly reduced the rate of its subsequent progression. Progression was also retarded when treatment was commenced (intervention group) after proteinuria had become established (4 months; ages 24–25 weeks). In either treatment mode, rosiglitazone normalized urinary N-acetyl-β-D-glucosaminidase activity, a marker for renal proximal tubular damage, and ameliorated the rise in systolic blood pressure that occurred coincidentally with the development of proteinuria in Zucker fatty control rats. The renal protective action of rosiglitazone was verified morphologically. Thus in the prevention group there was an absence of the various indexes of chronic nephropathy that were prominent in the Zucker fatty control group, namely, glomerulosclerosis, dilated tubules containing proteinaceous casts, a loss of functional microvilli on the tubular epithelium, and varying degrees of chronic interstitial nephritis. An intermediate pathology was observed in the intervention group. Also, pancreatic islet hyperplasia, ultrastructural evidence of (β-cell work hypertrophy, and derangement of α-cell distribution within the islet were prominent features of Zucker fatty control rats, but these adaptive changes were ameliorated (intervention group) or prevented (prevention group) by rosiglitazone treatment. These data demonstrate that treatment of Zucker fatty rats with rosiglitazone produced substantial protection over a prolonged period against the development and progression of renal injury and the adaptive changes to pancreatic islet morphology caused by sustained hyperinsulinemia.

  • Received October 27, 1997.
  • Revision received April 22, 1998.
  • Accepted April 22, 1998.
  • Copyright © 1998 by the American Diabetes Association

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August 1998, 47(8)
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Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats
Robin E Buckingham, Kamal A Al-Barazanji, C D Nigel Toseland, Mark Slaughter, Susan C Connor, Andrew West, Brian Bond, Nicholas C Turner, John C Clapham
Diabetes Aug 1998, 47 (8) 1326-1334; DOI: 10.2337/diab.47.8.1326

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Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats
Robin E Buckingham, Kamal A Al-Barazanji, C D Nigel Toseland, Mark Slaughter, Susan C Connor, Andrew West, Brian Bond, Nicholas C Turner, John C Clapham
Diabetes Aug 1998, 47 (8) 1326-1334; DOI: 10.2337/diab.47.8.1326
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