• S E Kahn,
• S Andrikopoulos,
• and C B Verchere

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

• M Wang,
• S C Wise,
• T Leff,
• and T Z Su

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.

• E Cersosimo,
• P Garlick,
• and J Ferretti

Renal glucose production during insulin-induced hypoglycemia in humans.

• J A Harrold,
• P S Widdowson,
• and G Williams

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

• R L Bradley and
• B Cheatham

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

• S Uotani,
• C Bjørbaek,
• J Tornøe,
• and J S Flier

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

• Y Minokoshi,
• M S Haque,
• and T Shimazu

Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats.

• K Ekberg,
• B R Landau,
• A Wajngot,
• V Chandramouli,
• S Efendic,
• H Brunengraber,
• and J Wahren

Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting.

• T Ellis,
• E Jodoin,
• E Ottendorfer,
• P Salisbury,
• J X She,
• D Schatz,
• and M A Atkinson

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM.

• H Mashima,
• S Yamada,
• T Tajima,
• M Seno,
• H Yamada,
• J Takeda,
• and I Kojima

Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells.

• Y B Kim,
• J S Zhu,
• J R Zierath,
• H Q Shen,
• A D Baron,
• and B B Kahn

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

• J M Gibson,
• M Westwood,
• F F Lauszus,
• J G Klebe,
• A Flyvbjerg,
• and A White

Phosphorylated insulin-like growth factor binding protein 1 is increased in pregnant diabetic subjects.

• M C Delmas-Beauvieux,
• B Quesson,
• E Thiaudière,
• J L Gallis,
• P Canioni,
• and H Gin

13C nuclear magnetic resonance study of glycogen resynthesis in muscle after glycogen-depleting exercise in healthy men receiving an infusion of lipid emulsion.

• P J Havel,
• R Townsend,
• L Chaump,
• and K Teff

High-fat meals reduce 24-h circulating leptin concentrations in women.

• D C Henly,
• M C Chauvet,
• and J W Phillips

Hepatic glucose cycling does not contribute to the development of hyperglycemia in Zucker diabetic fatty rats.

• S Guven,
• A El-Bershawi,
• G E Sonnenberg,
• C R Wilson,
• R G Hoffmann,
• G R Krakower,
• and A H Kissebah

Plasma leptin and insulin levels in weight-reduced obese women with normal body mass index: relationships with body composition and insulin.

• P Faure,
• E Rossini,
• N Wiernsperger,
• M J Richard,
• A Favier,
• and S Halimi

An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats.

• M Roden,
• M Krssak,
• H Stingl,
• S Gruber,
• A Hofer,
• C Fürnsinn,
• E Moser,
• and W Waldhäusl

Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans.

• K E Zakrzewska,
• I Cusin,
• A Stricker-Krongrad,
• O Boss,
• D Ricquier,
• B Jeanrenaud,
• and F Rohner-Jeanrenaud

Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat.

• A T Lee,
• D Reis,
• and U J Eriksson

Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo.

• A Flyvbjerg,
• W F Bennett,
• R Rasch,
• J J Kopchick,
• and J A Scarlett

Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy, and urinary albumin excretion in experimental diabetes in mice.

Effect of intensive diabetes treatment on carotid artery wall thickness in the epidemiology of diabetes interventions and complications. Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group.

• A Avogaro,
• L Calò,
• F Piarulli,
• M Miola,
• S deKreutzenberg,
• A Maran,
• A Burlina,
• R Mingardi,
• A Tiengo,
• and S Del Prato

Effect of acute ketosis on the endothelial function of type 1 diabetic patients: the role of nitric oxide.

• K Clément,
• C Dina,
• A Basdevant,
• N Chastang,
• V Pelloux,
• N Lahlou,
• M Berlan,
• D Langin,
• B Guy-Grand,
• and P Froguel

A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.

• L Hansen,
• H Fjordvang,
• S K Rasmussen,
• H Vestergaard,
• S M Echwald,
• T Hansen,
• D Alessi,
• S Shenolikar,
• A R Saltiel,
• F Barbetti,
• and O Pedersen

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.

• T Otonkoski,
• C Ammälä,
• H Huopio,
• G J Cote,
• J Chapman,
• K Cosgrove,
• R Ashfield,
• E Huang,
• J Komulainen,
• F M Ashcroft,
• M J Dunne,
• J Kere,
• and P M Thomas

A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland.

• I Iwata,
• S Nagafuchi,
• H Nakashima,
• S Kondo,
• T Koga,
• Y Yokogawa,
• T Akashi,
• T Shibuya,
• Y Umeno,
• T Okeda,
• S Shibata,
• S Kono,
• M Yasunami,
• H Ohkubo,
• and Y Niho

Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese.

• S Maeda,
• M Haneda,
• H Yasuda,
• T Tachikawa,
• K Isshiki,
• D Koya,
• M Terada,
• H Hidaka,
• A Kashiwagi,
• and R Kikkawa

Diabetic nephropathy is not associated with the dinucleotide repeat polymorphism upstream of the aldose reductase (ALR2) gene but with erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes.

• M Lehto,
• P O Bitzén,
• B Isomaa,
• C Wipemo,
• Y Wessman,
• C Forsblom,
• T Tuomi,
• M R Taskinen,
• and L Groop

Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism.

• M Nakata,
• T Yada,
• N Soejima,
• and I Maruyama

Leptin promotes aggregation of human platelets via the long form of its receptor.

• S Hidaka,
• T Kakuma,
• H Yoshimatsu,
• H Sakino,
• S Fukuchi,
• and T Sakata

Streptozotocin treatment upregulates uncoupling protein 3 expression in the rat heart.

• S Samec,
• J Seydoux,
• and A G Dulloo

Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: a link with insulin resistance.