Table of Contents

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- B Freiesleben De Blasio,
- P Bak,
- F Pociot,
- A E Karlsen,
- and J Nerup
Onset of type 1 diabetes: a dynamical instability.
Diabetes September 1999 48:1677-1685; doi:10.2337/diabetes.48.9.1677
- Abstract
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- S Daniel,
- M Noda,
- S G Straub,
- and G W Sharp
Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.
Diabetes September 1999 48:1686-1690; doi:10.2337/diabetes.48.9.1686
- Abstract
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- L M Botion and
- A Green
Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.
Diabetes September 1999 48:1691-1697; doi:10.2337/diabetes.48.9.1691
- Abstract
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- B Mahalingam,
- A Cuesta-Munoz,
- E A Davis,
- F M Matschinsky,
- R W Harrison,
- and I T Weber
Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.
Diabetes September 1999 48:1698-1705; doi:10.2337/diabetes.48.9.1698
- Abstract
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- M S Haque,
- Y Minokoshi,
- M Hamai,
- M Iwai,
- M Horiuchi,
- and T Shimazu
Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.
Diabetes September 1999 48:1706-1712; doi:10.2337/diabetes.48.9.1706
- Abstract
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- A G Murray,
- R C Nelson,
- G R Rayat,
- J F Elliott,
- and G S Korbutt
Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.
Diabetes September 1999 48:1713-1719; doi:10.2337/diabetes.48.9.1713
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- I Bergerot,
- G A Arreaza,
- M J Cameron,
- M D Burdick,
- R M Strieter,
- S W Chensue,
- S Chakrabarti,
- and T L Delovitch
Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.
Diabetes September 1999 48:1720-1729; doi:10.2337/diabetes.48.9.1720
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- N Giannoukakis,
- W A Rudert,
- S C Ghivizzani,
- A Gambotto,
- C Ricordi,
- M Trucco,
- and P D Robbins
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
Diabetes September 1999 48:1730-1736; doi:10.2337/diabetes.48.9.1730
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- R P Robertson,
- D E Sutherland,
- and K J Lanz
Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.
Diabetes September 1999 48:1737-1740; doi:10.2337/diabetes.48.9.1737
- Abstract
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- T Kanno,
- S Suga,
- K Nakano,
- N Kamimura,
- and M Wakui
Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells.
Diabetes September 1999 48:1741-1746; doi:10.2337/diabetes.48.9.1741
- Abstract
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- Y Q Liu,
- K Tornheim,
- and J L Leahy
Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Diabetes September 1999 48:1747-1753; doi:10.2337/diabetes.48.9.1747
- Abstract
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- S A Metz,
- M Meredith,
- J Vadakekalam,
- M E Rabaglia,
- and A Kowluru
A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.
Diabetes September 1999 48:1754-1762; doi:10.2337/diabetes.48.9.1754
- Abstract
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- X J Yang,
- L M Kow,
- T Funabashi,
- and C V Mobbs
Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.
Diabetes September 1999 48:1763-1772; doi:10.2337/diabetes.48.9.1763
- Abstract
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- J Lou,
- F Triponez,
- J Oberholzer,
- H Wang,
- D Yu,
- L Buhler,
- N Cretin,
- G Mentha,
- C B Wollheim,
- and P Morel
Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.
Diabetes September 1999 48:1773-1778; doi:10.2337/diabetes.48.9.1773
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- M P Hermans,
- J C Levy,
- R J Morris,
- and R C Turner
Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes.
Diabetes September 1999 48:1779-1786; doi:10.2337/diabetes.48.9.1779
- Abstract
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- N Satoh,
- Y Ogawa,
- G Katsuura,
- Y Numata,
- T Tsuji,
- M Hayase,
- K Ebihara,
- H Masuzaki,
- K Hosoda,
- Y Yoshimasa,
- and K Nakao
Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.
Diabetes September 1999 48:1787-1793; doi:10.2337/diabetes.48.9.1787
- Abstract
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- A Oku,
- K Ueta,
- K Arakawa,
- T Ishihara,
- M Nawano,
- Y Kuronuma,
- M Matsumoto,
- A Saito,
- K Tsujihara,
- M Anai,
- T Asano,
- Y Kanai,
- and H Endou
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
Diabetes September 1999 48:1794-1800; doi:10.2337/diabetes.48.9.1794
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- M Matsuda,
- Y Liu,
- S Mahankali,
- Y Pu,
- A Mahankali,
- J Wang,
- R A DeFronzo,
- P T Fox,
- and J H Gao
Altered hypothalamic function in response to glucose ingestion in obese humans.
Diabetes September 1999 48:1801-1806; doi:10.2337/diabetes.48.9.1801
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- J E Friedman,
- T Ishizuka,
- J Shao,
- L Huston,
- T Highman,
- and P Catalano
Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.
Diabetes September 1999 48:1807-1814; doi:10.2337/diabetes.48.9.1807
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- S J Bradley,
- B A Kingwell,
- and G K McConell
Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.
Diabetes September 1999 48:1815-1821; doi:10.2337/diabetes.48.9.1815
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- Y Ogawa,
- H Masuzaki,
- K Hosoda,
- M Aizawa-Abe,
- J Suga,
- M Suda,
- K Ebihara,
- H Iwai,
- N Matsuoka,
- N Satoh,
- H Odaka,
- H Kasuga,
- Y Fujisawa,
- G Inoue,
- H Nishimura,
- Y Yoshimasa,
- and K Nakao
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.
Diabetes September 1999 48:1822-1829; doi:10.2337/diabetes.48.9.1822
- Abstract
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- Y Tang,
- H Osawa,
- H Onuma,
- T Nishimiya,
- M Ochi,
- and H Makino
Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.
Diabetes September 1999 48:1830-1835; doi:10.2337/diabetes.48.9.1830
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- A T Santomauro,
- G Boden,
- M E Silva,
- D M Rocha,
- R F Santos,
- M J Ursich,
- P G Strassmann,
- and B L Wajchenberg
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
Diabetes September 1999 48:1836-1841; doi:10.2337/diabetes.48.9.1836
- Abstract
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- R Shibayama,
- N Araki,
- R Nagai,
- and S Horiuchi
Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.
Diabetes September 1999 48:1842-1849; doi:10.2337/diabetes.48.9.1842
- Abstract
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- S K Jain and
- R McVie
Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.
Diabetes September 1999 48:1850-1855; doi:10.2337/diabetes.48.9.1850
- Abstract
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- A E Caballero,
- S Arora,
- R Saouaf,
- S C Lim,
- P Smakowski,
- J Y Park,
- G L King,
- F W LoGerfo,
- E S Horton,
- and A Veves
Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.
Diabetes September 1999 48:1856-1862; doi:10.2337/diabetes.48.9.1856
- Abstract
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- B D Mitchell,
- S A Cole,
- A G Comuzzie,
- L Almasy,
- J Blangero,
- J W MacCluer,
- and J E Hixson
A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor.
Diabetes September 1999 48:1863-1867; doi:10.2337/diabetes.48.9.1863
- Abstract
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- H H Lei,
- J Coresh,
- A R Shuldiner,
- E Boerwinkle,
- and F L Brancati
Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.
Diabetes September 1999 48:1868-1872; doi:10.2337/diabetes.48.9.1868
- Abstract
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- L Héron,
- A Virsolvy,
- F Apiou,
- A Le Cam,
- and D Bataille
Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.
Diabetes September 1999 48:1873-1876; doi:10.2337/diabetes.48.9.1873
- Abstract
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- L Vassen,
- W Wegrzyn,
- and L Klein-Hitpass
Human insulin receptor substrate-2: gene organization and promoter characterization.
Diabetes September 1999 48:1877-1880; doi:10.2337/diabetes.48.9.1877
- Abstract
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- A Pizzuti,
- L Frittitta,
- A Argiolas,
- R Baratta,
- I D Goldfine,
- M Bozzali,
- T Ercolino,
- G Scarlato,
- L Iacoviello,
- R Vigneri,
- V Tassi,
- and V Trischitta
A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.
Diabetes September 1999 48:1881-1884; doi:10.2337/diabetes.48.9.1881
- Abstract
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- J E Ayala,
- R S Streeper,
- J S Desgrosellier,
- S K Durham,
- A Suwanichkul,
- C A Svitek,
- J K Goldman,
- F G Barr,
- D R Powell,
- and R M O'Brien
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
Diabetes September 1999 48:1885-1889; doi:10.2337/diabetes.48.9.1885
- Abstract
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- W K Chung,
- A Luke,
- R S Cooper,
- C Rotini,
- A Vidal-Puig,
- M Rosenbaum,
- M Chua,
- G Solanes,
- M Zheng,
- L Zhao,
- C LeDuc,
- A Eisberg,
- F Chu,
- E Murphy,
- M Schreier,
- L Aronne,
- S Caprio,
- B Kahle,
- D Gordon,
- S M Leal,
- R Goldsmith,
- A L Andreu,
- C Bruno,
- S DiMauro,
- and R L Leibel
Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.
Diabetes September 1999 48:1890-1895; doi:10.2337/diabetes.48.9.1890
- Abstract
- Full Text (PDF)

Onset of type 1 diabetes: a dynamical instability.

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.

Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.

Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.

Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells.

Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.

Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes.

Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

Altered hypothalamic function in response to glucose ingestion in obese humans.

Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.

Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor.

Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.

Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.

Human insulin receptor substrate-2: gene organization and promoter characterization.

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

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