Table of Contents

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- J C Henquin
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Diabetes November 2000 49:1751-1760; doi:10.2337/diabetes.49.11.1751
- Abstract
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- A L Thompson and
- G J Cooney
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Diabetes November 2000 49:1761-1765; doi:10.2337/diabetes.49.11.1761
- Abstract
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- G R Collier,
- J S McMillan,
- K Windmill,
- K Walder,
- J Tenne-Brown,
- A de Silva,
- J Trevaskis,
- S Jones,
- G J Morton,
- S Lee,
- G Augert,
- A Civitarese,
- and P Z Zimmet
Beacon: a novel gene involved in the regulation of energy balance.
Diabetes November 2000 49:1766-1771; doi:10.2337/diabetes.49.11.1766
- Abstract
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- L Dombrowski,
- R Faure,
- and A Marette
Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.
Diabetes November 2000 49:1772-1782; doi:10.2337/diabetes.49.11.1772
- Abstract
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- A G Kayali,
- D A Austin,
- and N J Webster
Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.
Diabetes November 2000 49:1783-1793; doi:10.2337/diabetes.49.11.1783
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- R Somwar,
- M Perreault,
- S Kapur,
- C Taha,
- G Sweeney,
- T Ramlal,
- D Y Kim,
- J Keen,
- C H Côte,
- A Klip,
- and A Marette
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
Diabetes November 2000 49:1794-1800; doi:10.2337/diabetes.49.11.1794
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- S Seewaldt,
- H E Thomas,
- M Ejrnaes,
- U Christen,
- T Wolfe,
- E Rodrigo,
- B Coon,
- B Michelsen,
- T W Kay,
- and M G von Herrath
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.
Diabetes November 2000 49:1801-1809; doi:10.2337/diabetes.49.11.1801
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- W Suarez-Pinzon,
- G S Korbutt,
- R Power,
- J Hooton,
- R V Rajotte,
- and A Rabinovitch
Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.
Diabetes November 2000 49:1810-1818; doi:10.2337/diabetes.49.11.1810
- Abstract
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- N E John,
- H U Andersen,
- S J Fey,
- P M Larsen,
- P Roepstorff,
- M R Larsen,
- F Pociot,
- A E Karlsen,
- J Nerup,
- I C Green,
- and T Mandrup-Poulsen
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes November 2000 49:1819-1829; doi:10.2337/diabetes.49.11.1819
- Abstract
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- N Koriyama,
- M Kakei,
- M Nakazaki,
- K Yaekura,
- K Ichinari,
- Q Gong,
- S Morimitsu,
- T Yada,
- and C Tei
PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.
Diabetes November 2000 49:1830-1839; doi:10.2337/diabetes.49.11.1830
- Abstract
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- A Björklund,
- A Lansner,
- and V E Grill
Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.
Diabetes November 2000 49:1840-1848; doi:10.2337/diabetes.49.11.1840
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- N Druzhyna,
- M E Smulson,
- S P LeDoux,
- and G L Wilson
Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.
Diabetes November 2000 49:1849-1855; doi:10.2337/diabetes.49.11.1849
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- A R Clocquet,
- J M Egan,
- D A Stoffers,
- D C Muller,
- L Wideman,
- G A Chin,
- W L Clarke,
- J B Hanks,
- J F Habener,
- and D Elahi
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).
Diabetes November 2000 49:1856-1864; doi:10.2337/diabetes.49.11.1856
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- N M Sanders and
- S Ritter
Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.
Diabetes November 2000 49:1865-1874; doi:10.2337/diabetes.49.11.1865
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- C Dodt,
- P Lönnroth,
- H L Fehm,
- and M Elam
The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.
Diabetes November 2000 49:1875-1879; doi:10.2337/diabetes.49.11.1875
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- N Kubota,
- K Tobe,
- Y Terauchi,
- K Eto,
- T Yamauchi,
- R Suzuki,
- Y Tsubamoto,
- K Komeda,
- R Nakano,
- H Miki,
- S Satoh,
- H Sekihara,
- S Sciacchitano,
- M Lesniak,
- S Aizawa,
- R Nagai,
- S Kimura,
- Y Akanuma,
- S I Taylor,
- and T Kadowaki
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Diabetes November 2000 49:1880-1889; doi:10.2337/diabetes.49.11.1880
- Abstract
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- M Ziotopoulou,
- D M Erani,
- S M Hileman,
- C Bjørbaek,
- and C S Mantzoros
Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.
Diabetes November 2000 49:1890-1896; doi:10.2337/diabetes.49.11.1890
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- S N Davis,
- S Mann,
- P Galassetti,
- R A Neill,
- D Tate,
- A C Ertl,
- and F Costa
Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.
Diabetes November 2000 49:1897-1903; doi:10.2337/diabetes.49.11.1897
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- J M Youd,
- S Rattigan,
- and M G Clark
Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.
Diabetes November 2000 49:1904-1909; doi:10.2337/diabetes.49.11.1904
- Abstract
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- O Gavrilova,
- B Marcus-Samuels,
- and M L Reitman
Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.
Diabetes November 2000 49:1910-1916; doi:10.2337/diabetes.49.11.1910
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- H Makimura,
- T M Mizuno,
- J Roberts,
- J Silverstein,
- J Beasley,
- and C V Mobbs
Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.
Diabetes November 2000 49:1917-1923; doi:10.2337/diabetes.49.11.1917
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- M Aragno,
- S Parola,
- E Brignardello,
- A Mauro,
- E Tamagno,
- R Manti,
- O Danni,
- and G Boccuzzi
Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.
Diabetes November 2000 49:1924-1931; doi:10.2337/diabetes.49.11.1924
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- S Srinivasan,
- M Stevens,
- and J W Wiley
Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.
Diabetes November 2000 49:1932-1938; doi:10.2337/diabetes.49.11.1932
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- T Inoguchi,
- P Li,
- F Umeda,
- H Y Yu,
- M Kakimoto,
- M Imamura,
- T Aoki,
- T Etoh,
- T Hashimoto,
- M Naruse,
- H Sano,
- H Utsumi,
- and H Nawata
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
Diabetes November 2000 49:1939-1945; doi:10.2337/diabetes.49.11.1939
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- J P Stoehr,
- S T Nadler,
- K L Schueler,
- M E Rabaglia,
- B S Yandell,
- S A Metz,
- and A D Attie
Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.
Diabetes November 2000 49:1946-1954; doi:10.2337/diabetes.49.11.1946
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- Y Horikawa,
- Y Horikawa,
- N J Cox,
- N Iwasaki,
- M Ogata,
- Y Iwamoto,
- V Schwitzgebel,
- M S German,
- and G I Bell
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Diabetes November 2000 49:1955-1957; doi:10.2337/diabetes.49.11.1955
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- C Vigouroux,
- J Magré,
- M C Vantyghem,
- C Bourut,
- O Lascols,
- S Shackleton,
- D J Lloyd,
- B Guerci,
- G Padova,
- P Valensi,
- A Grimaldi,
- R Piquemal,
- P Touraine,
- R C Trembath,
- and J Capeau
Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.
Diabetes November 2000 49:1958-1962; doi:10.2337/diabetes.49.11.1958
- Abstract
- Full Text (PDF)

Diabetes

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Beacon: a novel gene involved in the regulation of energy balance.

Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.

Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.

Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.

PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.

Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.

Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.

The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.

Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.

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