Table of Contents

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- C B Newgard,
- M J Brady,
- R M O'Doherty,
- and A R Saltiel
Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
Diabetes December 2000 49:1967-1977; doi:10.2337/diabetes.49.12.1967
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- L G Fryer,
- E Hajduch,
- F Rencurel,
- I P Salt,
- H S Hundal,
- D G Hardie,
- and D Carling
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
Diabetes December 2000 49:1978-1985; doi:10.2337/diabetes.49.12.1978
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- L Ma,
- N Tamarina,
- Y Wang,
- A Kuznetsov,
- N Patel,
- C Kending,
- B J Hering,
- and L H Philipson
Baculovirus-mediated gene transfer into pancreatic islet cells.
Diabetes December 2000 49:1986-1991; doi:10.2337/diabetes.49.12.1986
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- C A Gysemans,
- M Waer,
- D Valckx,
- J M Laureys,
- D Mihkalsky,
- R Bouillon,
- and C Mathieu
Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.
Diabetes December 2000 49:1992-1997; doi:10.2337/diabetes.49.12.1992
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- K Fujihira,
- M Nagata,
- H Moriyama,
- H Yasuda,
- K Arisawa,
- M Nakayama,
- S Maeda,
- M Kasuga,
- K Okumura,
- H Yagita,
- and K Yokono
Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.
Diabetes December 2000 49:1998-2006; doi:10.2337/diabetes.49.12.1998
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- D V Serreze,
- C M Post,
- H D Chapman,
- E A Johnson,
- B Lu,
- and P B Rothman
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
Diabetes December 2000 49:2007-2011; doi:10.2337/diabetes.49.12.2007
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- J S Dillon,
- G C Yaney,
- Y Zhou,
- N Voilley,
- S Bowen,
- S Chipkin,
- C R Bliss,
- V Schultz,
- F C Schuit,
- M Prentki,
- D J Waxman,
- and B E Corkey
Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
Diabetes December 2000 49:2012-2020; doi:10.2337/diabetes.49.12.2012
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- K Yamamoto,
- J Miyagawa,
- M Waguri,
- R Sasada,
- K Igarashi,
- M Li,
- T Nammo,
- M Moriwaki,
- A Imagawa,
- K Yamagata,
- H Nakajima,
- M Namba,
- Y Tochino,
- T Hanafusa,
- and Y Matsuzawa
Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
Diabetes December 2000 49:2021-2027; doi:10.2337/diabetes.49.12.2021
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- C M Antunes,
- A P Salgado,
- L M Rosário,
- and R M Santos
Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.
Diabetes December 2000 49:2028-2038; doi:10.2337/diabetes.49.12.2028
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- M K Thomas,
- N Rastalsky,
- J H Lee,
- and J F Habener
Hedgehog signaling regulation of insulin production by pancreatic beta-cells.
Diabetes December 2000 49:2039-2047; doi:10.2337/diabetes.49.12.2039
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- M Stubbs,
- S Aiston,
- and L Agius
Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.
Diabetes December 2000 49:2048-2055; doi:10.2337/diabetes.49.12.2048
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- S Andrikopoulos,
- C B Verchere,
- Y Terauchi,
- T Kadowaki,
- and S E Kahn
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
Diabetes December 2000 49:2056-2062; doi:10.2337/diabetes.49.12.2056
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- R S Hundal,
- M Krssak,
- S Dufour,
- D Laurent,
- V Lebon,
- V Chandramouli,
- S E Inzucchi,
- W C Schumann,
- K F Petersen,
- B R Landau,
- and G I Shulman
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Diabetes December 2000 49:2063-2069; doi:10.2337/diabetes.49.12.2063
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- G Veerababu,
- J Tang,
- R T Hoffman,
- M C Daniels,
- L F Hebert, Jr,
- E D Crook,
- R C Cooksey,
- and D A McClain
Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.
Diabetes December 2000 49:2070-2078; doi:10.2337/diabetes.49.12.2070
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- J C Parker,
- R K McPherson,
- K M Andrews,
- C B Levy,
- J S Dubins,
- J E Chin,
- P V Perry,
- B Hulin,
- D A Perry,
- T Inagaki,
- K A Dekker,
- K Tachikawa,
- Y Sugie,
- and J L Treadway
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
Diabetes December 2000 49:2079-2086; doi:10.2337/diabetes.49.12.2079
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- M K Dea,
- G W Van Citters,
- M Ader,
- S D Mittelman,
- A L Sunehag,
- and R N Bergman
Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.
Diabetes December 2000 49:2087-2093; doi:10.2337/diabetes.49.12.2087
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- C Weyer,
- R L Hanson,
- P A Tataranni,
- C Bogardus,
- and R E Pratley
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.
Diabetes December 2000 49:2094-2101; doi:10.2337/diabetes.49.12.2094
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- E E Blaak,
- D P van Aggel-Leijssen,
- A J Wagenmakers,
- W H Saris,
- and M A van Baak
Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
Diabetes December 2000 49:2102-2107; doi:10.2337/diabetes.49.12.2102
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- E Bakopanos and
- J E Silva
Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
Diabetes December 2000 49:2108-2115; doi:10.2337/diabetes.49.12.2108
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- S D Mittelman,
- G W Van Citters,
- S P Kim,
- D A Davis,
- M K Dea,
- M Hamilton-Wessler,
- and R N Bergman
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.
Diabetes December 2000 49:2116-2125; doi:10.2337/diabetes.49.12.2116
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- F Mauvais-Jarvis,
- A Virkamaki,
- M D Michael,
- J N Winnay,
- A Zisman,
- R N Kulkarni,
- and C R Kahn
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
Diabetes December 2000 49:2126-2134; doi:10.2337/diabetes.49.12.2126
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- M F Nielsen,
- B Nyholm,
- A Caumo,
- V Chandramouli,
- W C Schumann,
- C Cobelli,
- B R Landau,
- R A Rizza,
- and O Schmitz
Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.
Diabetes December 2000 49:2135-2141; doi:10.2337/diabetes.49.12.2135
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- M Lepore,
- S Pampanelli,
- C Fanelli,
- F Porcellati,
- L Bartocci,
- A Di Vincenzo,
- C Cordoni,
- E Costa,
- P Brunetti,
- and G B Bolli
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
Diabetes December 2000 49:2142-2148; doi:10.2337/diabetes.49.12.2142
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- S Enoksson,
- M Talbot,
- F Rife,
- W V Tamborlane,
- R S Sherwin,
- and S Caprio
Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.
Diabetes December 2000 49:2149-2153; doi:10.2337/diabetes.49.12.2149
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- A L Hevener,
- D Reichart,
- and J Olefsky
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
Diabetes December 2000 49:2154-2159; doi:10.2337/diabetes.49.12.2154
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- A J Jenkins,
- V Velarde,
- R L Klein,
- K C Joyce,
- K D Phillips,
- R K Mayfield,
- T J Lyons,
- and A A Jaffa
Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.
Diabetes December 2000 49:2160-2169; doi:10.2337/diabetes.49.12.2160
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- A Ceriello,
- A Morocutti,
- F Mercuri,
- L Quagliaro,
- M Moro,
- G Damante,
- and G C Viberti
Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
Diabetes December 2000 49:2170-2177; doi:10.2337/diabetes.49.12.2170
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- O A Sandu,
- L Ragolia,
- and N Begum
Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.
Diabetes December 2000 49:2178-2189; doi:10.2337/diabetes.49.12.2178
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- S Araki,
- D K Moczulski,
- L Hanna,
- L J Scott,
- J H Warram,
- and A S Krolewski
APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.
Diabetes December 2000 49:2190-2195; doi:10.2337/diabetes.49.12.2190
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- C Le Stunff,
- C Le Bihan,
- N J Schork,
- and P Bougnères
A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.
Diabetes December 2000 49:2196-2200; doi:10.2337/diabetes.49.12.2196
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- J B Meigs,
- L A Cupples,
- and P W Wilson
Parental transmission of type 2 diabetes: the Framingham Offspring Study.
Diabetes December 2000 49:2201-2207; doi:10.2337/diabetes.49.12.2201
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- D Dabelea,
- R L Hanson,
- R S Lindsay,
- D J Pettitt,
- G Imperatore,
- M M Gabir,
- J Roumain,
- P H Bennett,
- and W C Knowler
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.
Diabetes December 2000 49:2208-2211; doi:10.2337/diabetes.49.12.2208
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- T Klupa,
- M T Malecki,
- M Pezzolesi,
- L Ji,
- S Curtis,
- C D Langefeld,
- S S Rich,
- J H Warram,
- and A S Krolewski
Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.
Diabetes December 2000 49:2212-2216; doi:10.2337/diabetes.49.12.2212
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- S Nejentsev,
- Z Gombos,
- A P Laine,
- R Veijola,
- M Knip,
- O Simell,
- O Vaarala,
- H K Akerblom,
- and J Ilonen
Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.
Diabetes December 2000 49:2217-2221; doi:10.2337/diabetes.49.12.2217
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- M Collison,
- A M Glazier,
- D Graham,
- J J Morton,
- M H Dominiczak,
- T J Aitman,
- J M Connell,
- G W Gould,
- and A F Dominiczak
Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.
Diabetes December 2000 49:2222-2226; doi:10.2337/diabetes.49.12.2222
- Abstract
- Full Text (PDF)

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

Baculovirus-mediated gene transfer into pancreatic islet cells.

Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.

Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.

Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.

Hedgehog signaling regulation of insulin production by pancreatic beta-cells.

Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.

Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.

Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.

Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.

Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.

Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.

Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.

APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.

A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.

Parental transmission of type 2 diabetes: the Framingham Offspring Study.

Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.

Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.

Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.

Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.

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