Table of Contents

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- D E Kelley and
- L J Mandarino
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Diabetes May 2000 49:677-683; doi:10.2337/diabetes.49.5.677
- Abstract
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- R R Shankar,
- Y Wu,
- H Q Shen,
- J S Zhu,
- and A D Baron
Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.
Diabetes May 2000 49:684-687; doi:10.2337/diabetes.49.5.684
- Abstract
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- P Löfgren,
- V van Harmelen,
- S Reynisdottir,
- E Näslund,
- M Rydén,
- S Rössner,
- and P Arner
Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.
Diabetes May 2000 49:688-692; doi:10.2337/diabetes.49.5.688
- Abstract
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- R M Lynch,
- L S Tompkins,
- H L Brooks,
- A A Dunn-Meynell,
- and B E Levin
Localization of glucokinase gene expression in the rat brain.
Diabetes May 2000 49:693-700; doi:10.2337/diabetes.49.5.693
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- M Roden,
- H Stingl,
- V Chandramouli,
- W C Schumann,
- A Hofer,
- B R Landau,
- P Nowotny,
- W Waldhäusl,
- and G I Shulman
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.
Diabetes May 2000 49:701-707; doi:10.2337/diabetes.49.5.701
- Abstract
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- D V Serreze,
- E W Ottendorfer,
- T M Ellis,
- C J Gauntt,
- and M A Atkinson
Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.
Diabetes May 2000 49:708-711; doi:10.2337/diabetes.49.5.708
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- H Yajima,
- M Komatsu,
- S Yamada,
- S G Straub,
- T Kaneko,
- Y Sato,
- K Yamauchi,
- K Hashizume,
- G W Sharp,
- and T Aizawa
Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.
Diabetes May 2000 49:712-717; doi:10.2337/diabetes.49.5.712
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- S Farfari,
- V Schulz,
- B Corkey,
- and M Prentki
Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.
Diabetes May 2000 49:718-726; doi:10.2337/diabetes.49.5.718
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- V Serre-Beinier,
- S Le Gurun,
- N Belluardo,
- A Trovato-Salinaro,
- A Charollais,
- J A Haefliger,
- D F Condorelli,
- and P Meda
Cx36 preferentially connects beta-cells within pancreatic islets.
Diabetes May 2000 49:727-734; doi:10.2337/diabetes.49.5.727
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- G Patanè,
- S Piro,
- A M Rabuazzo,
- M Anello,
- R Vigneri,
- and F Purrello
Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.
Diabetes May 2000 49:735-740; doi:10.2337/diabetes.49.5.735
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- D A Stoffers,
- T J Kieffer,
- M A Hussain,
- D J Drucker,
- S Bonner-Weir,
- J F Habener,
- and J M Egan
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.
Diabetes May 2000 49:741-748; doi:10.2337/diabetes.49.5.741
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- L Ryysy,
- A M Häkkinen,
- T Goto,
- S Vehkavaara,
- J Westerbacka,
- J Halavaara,
- and H Yki-Järvinen
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.
Diabetes May 2000 49:749-758; doi:10.2337/diabetes.49.5.749
- Abstract
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- Y Fukui,
- S Masui,
- S Osada,
- K Umesono,
- and K Motojima
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.
Diabetes May 2000 49:759-767; doi:10.2337/diabetes.49.5.759
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- A D Baron,
- M Tarshoby,
- G Hook,
- E N Lazaridis,
- J Cronin,
- A Johnson,
- and H O Steinberg
Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.
Diabetes May 2000 49:768-774; doi:10.2337/diabetes.49.5.768
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- M J Holness,
- A Kraus,
- R A Harris,
- and M C Sugden
Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.
Diabetes May 2000 49:775-781; doi:10.2337/diabetes.49.5.775
- Abstract
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- T A Buchanan,
- A H Xiang,
- R K Peters,
- S L Kjos,
- K Berkowitz,
- A Marroquin,
- J Goico,
- C Ochoa,
- and S P Azen
Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.
Diabetes May 2000 49:782-788; doi:10.2337/diabetes.49.5.782
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- P V Carroll,
- E R Christ,
- A M Umpleby,
- I Gowrie,
- N Jackson,
- S B Bowes,
- R Hovorka,
- P Croos,
- P H Sönksen,
- and D L Russell-Jones
IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.
Diabetes May 2000 49:789-796; doi:10.2337/diabetes.49.5.789
- Abstract
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- J Bolinder,
- D A Kerckhoffs,
- E Moberg,
- E Hagström-Toft,
- and P Arner
Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.
Diabetes May 2000 49:797-802; doi:10.2337/diabetes.49.5.797
- Abstract
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- T C Wascher,
- G Wölkart,
- J C Russell,
- and F Brunner
Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats.
Diabetes May 2000 49:803-809; doi:10.2337/diabetes.49.5.803
- Abstract
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- A T Cheung,
- J Wang,
- D Ree,
- J K Kolls,
- and M Bryer-Ash
Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.
Diabetes May 2000 49:810-819; doi:10.2337/diabetes.49.5.810
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- N C Tkacs,
- A A Dunn-Meynell,
- and B E Levin
Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.
Diabetes May 2000 49:820-826; doi:10.2337/diabetes.49.5.820
- Abstract
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- K F Petersen,
- M Krssak,
- S Inzucchi,
- G W Cline,
- S Dufour,
- and G I Shulman
Mechanism of troglitazone action in type 2 diabetes.
Diabetes May 2000 49:827-831; doi:10.2337/diabetes.49.5.827
- Abstract
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- D Q Shih,
- H M Dansky,
- M Fleisher,
- G Assmann,
- S S Fajans,
- and M Stoffel
Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.
Diabetes May 2000 49:832-837; doi:10.2337/diabetes.49.5.832
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- J F Gautier,
- K Chen,
- A D Salbe,
- D Bandy,
- R E Pratley,
- M Heiman,
- E Ravussin,
- E M Reiman,
- and P A Tataranni
Differential brain responses to satiation in obese and lean men.
Diabetes May 2000 49:838-846; doi:10.2337/diabetes.49.5.838
- Abstract
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- Y B Kim,
- O D Peroni,
- T F Franke,
- and B B Kahn
Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.
Diabetes May 2000 49:847-856; doi:10.2337/diabetes.49.5.847
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- S O'Byrne,
- P Forte,
- L J Roberts, 2nd,
- J D Morrow,
- A Johnston,
- E Anggård,
- R D Leslie,
- and N Benjamin
Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.
Diabetes May 2000 49:857-862; doi:10.2337/diabetes.49.5.857
- Abstract
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- H J Goldberg,
- J Scholey,
- and I G Fantus
Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.
Diabetes May 2000 49:863-871; doi:10.2337/diabetes.49.5.863
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- B G Challis,
- G S Yeo,
- I S Farooqi,
- J Luan,
- S Aminian,
- D J Halsall,
- J M Keogh,
- N J Wareham,
- and S O'Rahilly
The CART gene and human obesity: mutational analysis and population genetics.
Diabetes May 2000 49:872-875; doi:10.2337/diabetes.49.5.872
- Abstract
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- L Hansen,
- J N Jensen,
- S Urioste,
- H V Petersen,
- F Pociot,
- H Eiberg,
- O P Kristiansen,
- T Hansen,
- P Serup,
- J Nerup,
- and O Pedersen
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.
Diabetes May 2000 49:876-878; doi:10.2337/diabetes.49.5.876
- Abstract
- Full Text (PDF)

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.

Localization of glucokinase gene expression in the rat brain.

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

Cx36 preferentially connects beta-cells within pancreatic islets.

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.

Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats.

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.

Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.

Mechanism of troglitazone action in type 2 diabetes.

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

Differential brain responses to satiation in obese and lean men.

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

The CART gene and human obesity: mutational analysis and population genetics.

NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

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