Table of Contents

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- R L Bradley,
- E G Kokkotou,
- E Maratos-Flier,
- and B Cheatham
Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.
Diabetes July 2000 49:1073-1077; doi:10.2337/diabetes.49.7.1073
- Abstract
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- P N Båvenholm,
- J Pigon,
- A K Saha,
- N B Ruderman,
- and S Efendic
Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.
Diabetes July 2000 49:1078-1083; doi:10.2337/diabetes.49.7.1078
- Abstract
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- P Nuutila,
- P Peltoniemi,
- V Oikonen,
- K Larmola,
- J Kemppainen,
- T Takala,
- H Sipilä,
- A Oksanen,
- U Ruotsalainen,
- G B Bolli,
- and H Yki-Järvinen
Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.
Diabetes July 2000 49:1084-1091; doi:10.2337/diabetes.49.7.1084
- Abstract
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- J R Daugaard,
- J N Nielsen,
- S Kristiansen,
- J L Andersen,
- M Hargreaves,
- and E A Richter
Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.
Diabetes July 2000 49:1092-1095; doi:10.2337/diabetes.49.7.1092
- Abstract
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- A V Skurat,
- A D Dietrich,
- and P J Roach
Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.
Diabetes July 2000 49:1096-1100; doi:10.2337/diabetes.49.7.1096
- Abstract
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- I Cusin,
- J Rouru,
- T Visser,
- A G Burger,
- and F Rohner-Jeanrenaud
Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.
Diabetes July 2000 49:1101-1105; doi:10.2337/diabetes.49.7.1101
- Abstract
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- D G Alleva,
- R P Pavlovich,
- C Grant,
- S B Kaser,
- and D I Beller
Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.
Diabetes July 2000 49:1106-1115; doi:10.2337/diabetes.49.7.1106
- Abstract
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- D Liu,
- D Pavlovic,
- M C Chen,
- M Flodström,
- S Sandler,
- and D L Eizirik
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
Diabetes July 2000 49:1116-1122; doi:10.2337/diabetes.49.7.1116
- Abstract
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- S Lortz,
- M Tiedge,
- T Nachtwey,
- A E Karlsen,
- J Nerup,
- and S Lenzen
Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.
Diabetes July 2000 49:1123-1130; doi:10.2337/diabetes.49.7.1123
- Abstract
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- M Kullin,
- Z Li,
- J B Hansen,
- E Björk,
- S Sandler,
- and F A Karlsson
K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.
Diabetes July 2000 49:1131-1136; doi:10.2337/diabetes.49.7.1131
- Abstract
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- J Seissler,
- T B Nguyen,
- G Aust,
- H Steinbrenner,
- and W A Scherbaum
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Diabetes July 2000 49:1137-1141; doi:10.2337/diabetes.49.7.1137
- Abstract
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- N Ban,
- Y Yamada,
- Y Someya,
- Y Ihara,
- T Adachi,
- A Kubota,
- R Watanabe,
- A Kuroe,
- A Inada,
- K Miyawaki,
- Y Sunaga,
- Z P Shen,
- T Iwakura,
- K Tsukiyama,
- S Toyokuni,
- K Tsuda,
- and Y Seino
Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.
Diabetes July 2000 49:1142-1148; doi:10.2337/diabetes.49.7.1142
- Abstract
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- E K Ainscow,
- C Zhao,
- and G A Rutter
Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.
Diabetes July 2000 49:1149-1155; doi:10.2337/diabetes.49.7.1149
- Abstract
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- G Skoglund,
- M A Hussain,
- and G G Holz
Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
Diabetes July 2000 49:1156-1164; doi:10.2337/diabetes.49.7.1156
- Abstract
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- F Rajas,
- M Croset,
- C Zitoun,
- S Montano,
- and G Mithieux
Induction of PEPCK gene expression in insulinopenia in rat small intestine.
Diabetes July 2000 49:1165-1168; doi:10.2337/diabetes.49.7.1165
- Abstract
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- S Jackson,
- S M Bagstaff,
- S Lynn,
- S J Yeaman,
- D M Turnbull,
- and M Walker
Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.
Diabetes July 2000 49:1169-1177; doi:10.2337/diabetes.49.7.1169
- Abstract
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- M Niklasson,
- A Holmäng,
- M Sjöstrand,
- L Strindberg,
- and P Lönnroth
Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.
Diabetes July 2000 49:1178-1185; doi:10.2337/diabetes.49.7.1178
- Abstract
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- E Cersosimo,
- P Garlick,
- and J Ferretti
Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.
Diabetes July 2000 49:1186-1193; doi:10.2337/diabetes.49.7.1186
- Abstract
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- M Caruso,
- C Miele,
- A Oliva,
- G Condorelli,
- F Oriente,
- G Riccardi,
- B Capaldo,
- F Fiory,
- D Accili,
- P Formisano,
- and F Beguinot
The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.
Diabetes July 2000 49:1194-1202; doi:10.2337/diabetes.49.7.1194
- Abstract
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- R S Surwit,
- C L Edwards,
- S Murthy,
- and A E Petro
Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.
Diabetes July 2000 49:1203-1208; doi:10.2337/diabetes.49.7.1203
- Abstract
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- J E Henriksen,
- K Levin,
- P Thye-Rønn,
- F Alford,
- O Hother-Nielsen,
- J J Holst,
- and H Beck-Nielsen
Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.
Diabetes July 2000 49:1209-1218; doi:10.2337/diabetes.49.7.1209
- Abstract
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- B Burguera,
- M E Couce,
- G L Curran,
- M D Jensen,
- R V Lloyd,
- M P Cleary,
- and J F Poduslo
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.
Diabetes July 2000 49:1219-1223; doi:10.2337/diabetes.49.7.1219
- Abstract
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- N Pedraza,
- G Solanes,
- M C Carmona,
- R Iglesias,
- O Viñas,
- T Mampel,
- M Vazquez,
- M Giralt,
- and F Villarroya
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Diabetes July 2000 49:1224-1230; doi:10.2337/diabetes.49.7.1224
- Abstract
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- H O Steinberg,
- G Paradisi,
- G Hook,
- K Crowder,
- J Cronin,
- and A D Baron
Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.
Diabetes July 2000 49:1231-1238; doi:10.2337/diabetes.49.7.1231
- Abstract
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- J Y Park,
- N Takahara,
- A Gabriele,
- E Chou,
- K Naruse,
- K Suzuma,
- T Yamauchi,
- S W Ha,
- M Meier,
- C J Rhodes,
- and G L King
Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Diabetes July 2000 49:1239-1248; doi:10.2337/diabetes.49.7.1239
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- G Pugliese,
- F Pricci,
- G Leto,
- L Amadio,
- C Iacobini,
- G Romeo,
- L Lenti,
- P Sale,
- R Gradini,
- F T Liu,
- and U Di Mario
The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.
Diabetes July 2000 49:1249-1257; doi:10.2337/diabetes.49.7.1249
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- F Chiarelli,
- F Cipollone,
- F Romano,
- S Tumini,
- F Costantini,
- L di Ricco,
- M Pomilio,
- S D Pierdomenico,
- M Marini,
- F Cuccurullo,
- and A Mezzetti
Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.
Diabetes July 2000 49:1258-1263; doi:10.2337/diabetes.49.7.1258
- Abstract
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- H Rau,
- M Kocova,
- S O'Rahilly,
- and J P Whitehead
Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.
Diabetes July 2000 49:1264-1268; doi:10.2337/diabetes.49.7.1264
- Abstract
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- M Tawata,
- J I Hayashi,
- K Isobe,
- E Ohkubo,
- M Ohtaka,
- J Chen,
- K Aida,
- and T Onaya
A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.
Diabetes July 2000 49:1269-1272; doi:10.2337/diabetes.49.7.1269
- Abstract
- Full Text (PDF)

Diabetes

Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.

Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.

Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.

Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.

Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.

Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

Induction of PEPCK gene expression in insulinopenia in rat small intestine.

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.

Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.

Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.

The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.

Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.

Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.

Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.

Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

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