Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 1.
FIG. 1.

The effect of GLP-1 and forskolin on pHi in clonal pancreatic β-cells. HIT cells (0.2 mg/ml) loaded with the pH indicator BCECF were suspended in 1.3 ml Krebs buffer containing no albumin (pH 7.4) at 30°C. Traces A and B show the acidification caused by the addition of GLP-1 or forskolin. Trace C shows the alkalinization caused by glucose addition followed by a small and transient acidification caused by GLP-1. The illustrations shown are representative of experiments repeated at least three times.

This Article

  1. Diabetes vol. 50 no. 1 56-62