Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)

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FIG. 9.
FIG. 9.

Model of the lipolytic pathway in β-cells. The model shows that GLP-1 activates HSL as a consequence of PKA stimulation via cAMP. HSL causes triglyceride breakdown to FFAs. This is followed by activation of FFAs via ACS in a triacsin C—inhibitable step with production of the effector signal LC-CoA. Malonyl CoA prevents the loss of this effector signal (or its products DAG and PA), by blocking its entry and subsequent oxidation in the mitochondria. CPT-1, carnitine palmitoyl transferase-1; TG, triglycerides.

This Article

  1. Diabetes vol. 50 no. 1 56-62