Table of Contents

Perspectives in Diabetes

Select this article
- Philippe A. Halban,
- Steven E. Kahn,
- Åke Lernmark,
- and Christopher J. Rhodes
Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes: How High Must the Standards Be Set?
Diabetes October 2001 50:2181-2191; doi:10.2337/diabetes.50.10.2181

Rapid Publications

Select this article
- Farrukh A. Khan,
- Paulette B. Goforth,
- Min Zhang,
- and Leslie S. Satin
Insulin Activates ATP-Sensitive K⁺ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway
Diabetes October 2001 50:2192-2198; doi:10.2337/diabetes.50.10.2192
Select this article
- David B. Savage,
- Ciaran P. Sewter,
- Ellen S. Klenk,
- David G. Segal,
- Antonio Vidal-Puig,
- Robert V. Considine,
- and Stephen O’Rahilly
Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans
Diabetes October 2001 50:2199-2202; doi:10.2337/diabetes.50.10.2199

Metabolism and Signal Transduction

Select this article
- Elizabeth R. Seaquist,
- Gregory S. Damberg,
- Ivan Tkac,
- and Rolf Gruetter
The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans
Diabetes October 2001 50:2203-2209; doi:10.2337/diabetes.50.10.2203
Select this article
- Rosanna Cazzolli,
- Lee Carpenter,
- Trevor J. Biden,
- and Carsten Schmitz-Peiffer
A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate
Diabetes October 2001 50:2210-2218; doi:10.2337/diabetes.50.10.2210

Immunology and Transplantation

Select this article
- Harry Heimberg,
- Yves Heremans,
- Christian Jobin,
- Ruth Leemans,
- Alessandra K. Cardozo,
- Martine Darville,
- and Décio L. Eizirik
Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents β-Cell Apoptosis
Diabetes October 2001 50:2219-2224; doi:10.2337/diabetes.50.10.2219

Islet Studies

Select this article
- Maria Sörhede Winzell,
- Håkan Svensson,
- Peter Arner,
- Bo Ahrén,
- and Cecilia Holm
The Expression of Hormone-Sensitive Lipase in Clonal β-Cells and Rat Islets Is Induced by Long-Term Exposure to High Glucose
Diabetes October 2001 50:2225-2230; doi:10.2337/diabetes.50.10.2225
Select this article
- Anna Moore,
- Susan Bonner-Weir,
- and Ralph Weissleder
Noninvasive In Vivo Measurement of β-Cell Mass in Mouse Model of Diabetes
Diabetes October 2001 50:2231-2236; doi:10.2337/diabetes.50.10.2231
Select this article
- Jean Buteau,
- Sylvain Foisy,
- Christopher J. Rhodes,
- Lee Carpenter,
- Trevor J. Biden,
- and Marc Prentki
Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation
Diabetes October 2001 50:2237-2243; doi:10.2337/diabetes.50.10.2237
Select this article
- Lucy J. Elrick and
- Kevin Docherty
Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1
Diabetes October 2001 50:2244-2252; doi:10.2337/diabetes.50.10.2244
Select this article
- Frank Reimann,
- Frances M. Ashcroft,
- and Fiona M. Gribble
Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action
Diabetes October 2001 50:2253-2259; doi:10.2337/diabetes.50.10.2253
Select this article
- Irina Berkovich and
- Shimon Efrat
Inducible and Reversible β-Cell Autoimmunity and Hyperplasia in Transgenic Mice Expressing a Conditional Oncogene
Diabetes October 2001 50:2260-2267; doi:10.2337/diabetes.50.10.2260

Complications

Select this article
- Lalit P. Singh,
- Jack Andy,
- Vivian Anyamale,
- Kennieth Greene,
- Michelle Alexander,
- and Errol D. Crook
Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C
Diabetes October 2001 50:2355-2362; doi:10.2337/diabetes.50.10.2355
Select this article
- Fabio Fiordaliso,
- Annarosa Leri,
- Daniela Cesselli,
- Federica Limana,
- Bijan Safai,
- Bernardo Nadal-Ginard,
- Piero Anversa,
- and Jan Kajstura
Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death
Diabetes October 2001 50:2363-2375; doi:10.2337/diabetes.50.10.2363
Select this article
- Hong Hua,
- Howard J. Goldberg,
- I.G. Fantus,
- and Catharine I. Whiteside
High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and α1(IV) Collagen Expression in Response to Endothelin-1: Role of Specific Protein Kinase C Isozymes
Diabetes October 2001 50:2376-2383; doi:10.2337/diabetes.50.10.2376

Epidemiology

Select this article
- Joshua I. Barzilay,
- Linn Abraham,
- Susan R. Heckbert,
- Mary Cushman,
- Lewis H. Kuller,
- Helaine E. Resnick,
- and Russell P. Tracy
The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study
Diabetes October 2001 50:2384-2389; doi:10.2337/diabetes.50.10.2384
Select this article
- Katherine M. Conigrave,
- B. Frank Hu,
- Carlos A. Camargo,
- Meir J. Stampfer,
- Walter C. Willett,
- and Eric B. Rimm
A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men
Diabetes October 2001 50:2390-2395; doi:10.2337/diabetes.50.10.2390

Genetics

Select this article
- Jussi Pihlajamäki,
- Melissa Austin,
- Karen Edwards,
- and Markku Laakso
A Major Gene Effect on Fasting Insulin and Insulin Sensitivity in Familial Combined Hyperlipidemia
Diabetes October 2001 50:2396-2401; doi:10.2337/diabetes.50.10.2396

Brief Genetics Report

Select this article
- Cecilia M. Lindgren,
- Anita Nilsson,
- Marju Orho-Melander,
- Peter Almgren,
- and Leif C. Groop
Characterization of the Annexin I Gene and Evaluation of Its Role in Type 2 Diabetes
Diabetes October 2001 50:2402-2405; doi:10.2337/diabetes.50.10.2402
Select this article
- Tao Cai,
- Jingping Xie,
- Jin-Xiong She,
- and Abner Louis Notkins
Analysis of the Coding and Promoter Regions of the Autoantigen IA-2 in Subjects With and Without Autoantibodies to IA-2
Diabetes October 2001 50:2406-2409; doi:10.2337/diabetes.50.10.2406
Select this article
- Johan Hoffstedt,
- Peter Arner,
- Martin Schalling,
- Nancy L. Pedersen,
- Selim Sengul,
- Susanne Ahlberg,
- Anastasia Iliadou,
- and Catharina Lavebratt
A Common Hormone-Sensitive Lipase i6 Gene Polymorphism Is Associated With Decreased Human Adipocyte Lipolytic Function
Diabetes October 2001 50:2410-2413; doi:10.2337/diabetes.50.10.2410

Erratum

Select this article

Erratum
Diabetes October 2001 50:2414-2415; doi:10.2337/diabetes.50.10.2414

Diabetes

Perspectives in Diabetes

Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes: How High Must the Standards Be Set?

Rapid Publications

Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans

Metabolism and Signal Transduction

The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans

A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

Immunology and Transplantation

Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents β-Cell Apoptosis

Islet Studies

The Expression of Hormone-Sensitive Lipase in Clonal β-Cells and Rat Islets Is Induced by Long-Term Exposure to High Glucose

Noninvasive In Vivo Measurement of β-Cell Mass in Mouse Model of Diabetes

Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1

Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action

Inducible and Reversible β-Cell Autoimmunity and Hyperplasia in Transgenic Mice Expressing a Conditional Oncogene

Pathophysiology

Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice

Intrauterine Growth Retardation Leads to the Development of Type 2 Diabetes in the Rat

Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression

Troglitazone Not Only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes

Pharmacological Antilipolysis Restores Insulin Sensitivity During Growth Hormone Exposure

Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes in Gene Expression

Thiazolidinedione Treatment Prevents Free Fatty Acid–Induced Insulin Resistance in Male Wistar Rats

Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells

Changes in Regional Brain 18F-Fluorodeoxyglucose Uptake at Hypoglycemia in Type 1 Diabetic Men Associated With Hypoglycemia Unawareness and Counter-Regulatory Failure

Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle

Increased Lactate Release per Fat Cell in Normoglycemic First-Degree Relatives of Individuals With Type 2 Diabetes

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

Complications

Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C

Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and α1(IV) Collagen Expression in Response to Endothelin-1: Role of Specific Protein Kinase C Isozymes

Epidemiology

The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study

A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men

Genetics

A Major Gene Effect on Fasting Insulin and Insulin Sensitivity in Familial Combined Hyperlipidemia

Brief Genetics Report

Characterization of the Annexin I Gene and Evaluation of Its Role in Type 2 Diabetes

Analysis of the Coding and Promoter Regions of the Autoantigen IA-2 in Subjects With and Without Autoantibodies to IA-2

A Common Hormone-Sensitive Lipase i6 Gene Polymorphism Is Associated With Decreased Human Adipocyte Lipolytic Function

Erratum

Erratum

This Issue

Current Issue

Insulin Activates ATP-Sensitive K⁺ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway

Changes in Regional Brain ¹⁸F-Fluorodeoxyglucose Uptake at Hypoglycemia in Type 1 Diabetic Men Associated With Hypoglycemia Unawareness and Counter-Regulatory Failure