Table of Contents

Rapid Publication

Select this article
- Joachim Spranger,
- Martin Osterhoff,
- Manja Reimann,
- Matthias Möhlig,
- Michael Ristow,
- Mary Kay Francis,
- Vincent Cristofalo,
- Hans-Peter Hammes,
- Gillian Smith,
- Michael Boulton,
- and Andreas F.H. Pfeiffer
Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease
Diabetes December 2001 50:2641-2645; doi:10.2337/diabetes.50.12.2641
Select this article
- Barry I. Hudson,
- Max H. Stickland,
- Peter J. Grant,
- and T. Simon Futers
Characterization of Allelic and Nucleotide Variation Between the RAGE Gene on Chromosome 6 and a Homologous Pseudogene Sequence to Its 5′ Regulatory Region on Chromosome 3: Implications for Polymorphic Studies in Diabetes
Diabetes December 2001 50:2646-2651; doi:10.2337/diabetes.50.12.2646

Metabolism and Signal Transduction

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- Yves Boirie,
- Kevin R. Short,
- Bo Ahlman,
- Michael Charlton,
- and K. Sreekumaran Nair
Tissue-Specific Regulation of Mitochondrial and Cytoplasmic Protein Synthesis Rates by Insulin
Diabetes December 2001 50:2652-2658; doi:10.2337/diabetes.50.12.2652
Select this article
- Stephen Rattigan,
- Michelle G. Wallis,
- Joanne M. Youd,
- and Michael G. Clark
Exercise Training Improves Insulin-Mediated Capillary Recruitment in Association With Glucose Uptake in Rat Hindlimb
Diabetes December 2001 50:2659-2665; doi:10.2337/diabetes.50.12.2659
Select this article
- Gabriela E. Bergonzelli,
- François P. Pralong,
- Micheline Glauser,
- Claudia Cavadas,
- Eric Grouzmann,
- and Rolf C. Gaillard
Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y
Diabetes December 2001 50:2666-2672; doi:10.2337/diabetes.50.12.2666
Select this article
- Zhentao Song,
- Barry E. Levin,
- Joseph J. McArdle,
- Nader Bakhos,
- and Vanessa H. Routh
Convergence of Pre- and Postsynaptic Influences on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus
Diabetes December 2001 50:2673-2681; doi:10.2337/diabetes.50.12.2673
Select this article
- Matthew Coggins,
- Jonathan Lindner,
- Steve Rattigan,
- Linda Jahn,
- Elizabeth Fasy,
- Sanjiv Kaul,
- and Eugene Barrett
Physiologic Hyperinsulinemia Enhances Human Skeletal Muscle Perfusion by Capillary Recruitment
Diabetes December 2001 50:2682-2690; doi:10.2337/diabetes.50.12.2682

Immunology and Transplantation

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- Yang Yang,
- Min Bao,
- and Ji-Won Yoon
Intrinsic Defects in the T-Cell Lineage Results in Natural Killer T-Cell Deficiency and the Development of Diabetes in the Nonobese Diabetic Mouse
Diabetes December 2001 50:2691-2699; doi:10.2337/diabetes.50.12.2691
Select this article
- Matthias G. von Herrath,
- Tom Wolfe,
- Ursula Möhrle,
- Bryan Coon,
- and Anna Hughes
Protection From Type 1 Diabetes in the Face of High Levels of Activated Autoaggressive Lymphocytes in a Viral Transgenic Mouse Model Crossed to the SV129 Strain
Diabetes December 2001 50:2700-2708; doi:10.2337/diabetes.50.12.2700
Select this article
- Luigi Laviola,
- Gaetana Belsanti,
- Alberto M. Davalli,
- Raffaele Napoli,
- Sebastio Perrini,
- Gordon C. Weir,
- Riccardo Giorgino,
- and Francesco Giorgino
Effects of Streptozocin Diabetes and Diabetes Treatment by Islet Transplantation on In Vivo Insulin Signaling in Rat Heart
Diabetes December 2001 50:2709-2720; doi:10.2337/diabetes.50.12.2709

Islet Studies

Select this article
- Christopher D. Major and
- Bryan A. Wolf
Interleukin-1β Stimulation of c-Jun NH₂-Terminal Kinase Activity in Insulin-Secreting Cells: Evidence for Cytoplasmic Restriction
Diabetes December 2001 50:2721-2728; doi:10.2337/diabetes.50.12.2721
Select this article
- Mary C. Sugden,
- Karen Bulmer,
- Daniel Augustine,
- and Mark J. Holness
Selective Modification of Pyruvate Dehydrogenase Kinase Isoform Expression in Rat Pancreatic Islets Elicited by Starvation and Activation of Peroxisome Proliferator–Activated Receptor-α: Implications for Glucose-Stimulated Insulin Secretion
Diabetes December 2001 50:2729-2736; doi:10.2337/diabetes.50.12.2729
Select this article
- Jian-Man Lin,
- Henrik Ortsäter,
- Hossein Fakhrai-Rad,
- Joakim Galli,
- Holger Luthman,
- and Peter Bergsten
Phenotyping of Individual Pancreatic Islets Locates Genetic Defects in Stimulus Secretion Coupling to Niddm1i Within the Major Diabetes Locus in GK Rats
Diabetes December 2001 50:2737-2743; doi:10.2337/diabetes.50.12.2737
Select this article
- Mark M.W. Chong,
- Helen E. Thomas,
- and Thomas W.H. Kay
γ-Interferon Signaling in Pancreatic β-Cells Is Persistent but Can Be Terminated by Overexpression of Suppressor of Cytokine Signaling-1
Diabetes December 2001 50:2744-2751; doi:10.2337/diabetes.50.12.2744
Select this article
- Adolfo García-Ocaña,
- Rupangi C. Vasavada,
- Ana Cebrian,
- Vasumathi Reddy,
- Karen K. Takane,
- Juan-Carlos López-Talavera,
- and Andrew F. Stewart
Transgenic Overexpression of Hepatocyte Growth Factor in the β-Cell Markedly Improves Islet Function and Islet Transplant Outcomes in Mice
Diabetes December 2001 50:2752-2762; doi:10.2337/diabetes.50.12.2752
Select this article
- S. A. Kassem,
- I. Ariel,
- P. S. Thornton,
- K. Hussain,
- V. Smith,
- K. J. Lindley,
- A. Aynsley-Green,
- and B. Glaser
p57^KIP2 Expression in Normal Islet Cells and in Hyperinsulinism of Infancy
Diabetes December 2001 50:2763-2769; doi:10.2337/diabetes.50.12.2763

Pathophysiology

Select this article
- Heidi Storgaard,
- Xiao Mei Song,
- Christine B. Jensen,
- Sten Madsbad,
- Marie Björnholm,
- Allan Vaag,
- and Juleen R. Zierath
Insulin Signal Transduction in Skeletal Muscle From Glucose-Intolerant Relatives With Type 2 Diabetes
Diabetes December 2001 50:2770-2778; doi:10.2337/diabetes.50.12.2770
Select this article
- Miek C. Jong,
- Peter J. Voshol,
- Martin Muurling,
- Vivian E.H. Dahlmans,
- Johannes A. Romijn,
- Hanno Pijl,
- and Louis M. Havekes
Protection From Obesity and Insulin Resistance in Mice Overexpressing Human Apolipoprotein C1
Diabetes December 2001 50:2779-2785; doi:10.2337/diabetes.50.12.2779
Select this article
- Jiali Wang,
- Silvana Obici,
- Kimyata Morgan,
- Nir Barzilai,
- Zhaohui Feng,
- and Luciano Rossetti
Overfeeding Rapidly Induces Leptin and Insulin Resistance
Diabetes December 2001 50:2786-2791; doi:10.2337/diabetes.50.12.2786
Select this article
- Angelika Bierhaus,
- Stephan Schiekofer,
- Markus Schwaninger,
- Martin Andrassy,
- Per M. Humpert,
- Jiang Chen,
- Mei Hong,
- Thomas Luther,
- Thomas Henle,
- Ingrid Klöting,
- Michael Morcos,
- Marion Hofmann,
- Hans Tritschler,
- Bernd Weigle,
- Michael Kasper,
- Mark Smith,
- George Perry,
- Ann-Marie Schmidt,
- David M. Stern,
- Hans-Ulrich Häring,
- Erwin Schleicher,
- and Peter P. Nawroth
Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB
Diabetes December 2001 50:2792-2808; doi:10.2337/diabetes.50.12.2792
Select this article
- Michèle Guerre-Millo,
- Christine Rouault,
- Philippe Poulain,
- Jocelyne André,
- Vincent Poitout,
- Jeffrey M. Peters,
- Frank J. Gonzalez,
- Jean-Charles Fruchart,
- Gérard Reach,
- and Bart Staels
PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance
Diabetes December 2001 50:2809-2814; doi:10.2337/diabetes.50.12.2809
Select this article
- Juei-Tang Cheng,
- I-Min Liu,
- Tzong-Cherng Chi,
- Thing-Fong Tzeng,
- Feng-Hwa Lu,
- and Chih Jen Chang
Plasma Glucose–Lowering Effect of Tramadol in Streptozotocin-Induced Diabetic Rats
Diabetes December 2001 50:2815-2821; doi:10.2337/diabetes.50.12.2815
Select this article
- Helena Corominola,
- Laura J. Conner,
- Lisa S. Beavers,
- Robert A. Gadski,
- Dwayne Johnson,
- Jose F. Caro,
- and Ronit Rafaeloff-Phail
Identification of Novel Genes Differentially Expressed in Omental Fat of Obese Subjects and Obese Type 2 Diabetic Patients
Diabetes December 2001 50:2822-2830; doi:10.2337/diabetes.50.12.2822
Select this article
- Nicole M. Sanders and
- Sue Ritter
Acute 2DG-Induced Glucoprivation or Dexamethasone Abolishes 2DG-Induced Glucoregulatory Responses to Subsequent Glucoprivation
Diabetes December 2001 50:2831-2836; doi:10.2337/diabetes.50.12.2831

Complications

Select this article
- Kyong Soo Park,
- Jae Hyeon Kim,
- Min Seon Kim,
- Jeong Mi Kim,
- Suk Kyeong Kim,
- Jeong Yun Choi,
- Myung Hee Chung,
- Boghee Han,
- Seong Yeon Kim,
- and Hong Kye Lee
Effects of Insulin and Antioxidant on Plasma 8-Hydroxyguanine and Tissue 8-Hydroxydeoxyguanosine in Streptozotocin-Induced Diabetic Rats
Diabetes December 2001 50:2837-2841; doi:10.2337/diabetes.50.12.2837
Select this article
- Laura J. Scott,
- James H. Warram,
- Linda S. Hanna,
- Lori M. B. Laffel,
- Louise Ryan,
- and Andrzej S. Krolewski
A Nonlinear Effect of Hyperglycemia and Current Cigarette Smoking Are Major Determinants of the Onset of Microalbuminuria in Type 1 Diabetes
Diabetes December 2001 50:2842-2849; doi:10.2337/diabetes.50.12.2842

Genetics

Select this article
- Robert S. Lindsay,
- Sayuko Kobes,
- William C. Knowler,
- Peter H. Bennett,
- and Robert L. Hanson
Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima Indians
Diabetes December 2001 50:2850-2857; doi:10.2337/diabetes.50.12.2850
Select this article
- Harold Snieder,
- Pamela A. Sawtell,
- Lesley Ross,
- James Walker,
- Tim D. Spector,
- and R. David Graham Leslie
HbA_1c Levels Are Genetically Determined Even in Type 1 Diabetes: Evidence From Healthy and Diabetic Twins
Diabetes December 2001 50:2858-2863; doi:10.2337/diabetes.50.12.2858
Select this article
- Yoshinori Shimajiri,
- Tokio Sanke,
- Hiroto Furuta,
- Tadashi Hanabusa,
- Takayuki Nakagawa,
- Yoshio Fujitani,
- Yoshitaka Kajimoto,
- Nobuyuki Takasu,
- and Kishio Nanjo
A Missense Mutation of Pax4 Gene (R121W) Is Associated With Type 2 Diabetes in Japanese
Diabetes December 2001 50:2864-2869; doi:10.2337/diabetes.50.12.2864

Brief Genetics Report

Select this article
- Patrick Schrauwen,
- Matthijs K.C. Hesselink,
- Ellen E. Blaak,
- Lars B. Borghouts,
- Gert Schaart,
- Wim H.M. Saris,
- and Hans A. Keizer
Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
Diabetes December 2001 50:2870-2873; doi:10.2337/diabetes.50.12.2870
Select this article
- Salah-Eddine Lamhamedi-Cherradi,
- Olivier Boulard,
- Cristina Gonzalez,
- Najiby Kassis,
- Diane Damotte,
- Laure Eloy,
- Guy Fluteau,
- Matthieu Lévi-Strauss,
- and Henri-Jean Garchon
Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice
Diabetes December 2001 50:2874-2878; doi:10.2337/diabetes.50.12.2874
Select this article
- Lars C. Stene,
- Per Magnus,
- Kjersti S. Rønningen,
- and Geir Joner
Diabetes-Associated HLA-DQ Genes and Birth Weight
Diabetes December 2001 50:2879-2882; doi:10.2337/diabetes.50.12.2879

Tribute

Select this article
- Christopher D. Saudek and
- Elizabeth A. Walker
Bruce R. Zimmerman, md: 1942–2001
Diabetes December 2001 50:2883; doi:10.2337/diabetes.50.12.2883

Erratum

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Erratum
Diabetes December 2001 50:2884; doi:10.2337/diabetes.50.12.2884

Diabetes

Rapid Publication

Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease

Characterization of Allelic and Nucleotide Variation Between the RAGE Gene on Chromosome 6 and a Homologous Pseudogene Sequence to Its 5′ Regulatory Region on Chromosome 3: Implications for Polymorphic Studies in Diabetes

Metabolism and Signal Transduction

Tissue-Specific Regulation of Mitochondrial and Cytoplasmic Protein Synthesis Rates by Insulin

Exercise Training Improves Insulin-Mediated Capillary Recruitment in Association With Glucose Uptake in Rat Hindlimb

Interplay Between Galanin and Leptin in the Hypothalamic Control of Feeding via Corticotropin-Releasing Hormone and Neuropeptide Y

Convergence of Pre- and Postsynaptic Influences on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus

Physiologic Hyperinsulinemia Enhances Human Skeletal Muscle Perfusion by Capillary Recruitment

Immunology and Transplantation

Intrinsic Defects in the T-Cell Lineage Results in Natural Killer T-Cell Deficiency and the Development of Diabetes in the Nonobese Diabetic Mouse

Protection From Type 1 Diabetes in the Face of High Levels of Activated Autoaggressive Lymphocytes in a Viral Transgenic Mouse Model Crossed to the SV129 Strain

Effects of Streptozocin Diabetes and Diabetes Treatment by Islet Transplantation on In Vivo Insulin Signaling in Rat Heart

Islet Studies

Interleukin-1β Stimulation of c-Jun NH2-Terminal Kinase Activity in Insulin-Secreting Cells: Evidence for Cytoplasmic Restriction

Selective Modification of Pyruvate Dehydrogenase Kinase Isoform Expression in Rat Pancreatic Islets Elicited by Starvation and Activation of Peroxisome Proliferator–Activated Receptor-α: Implications for Glucose-Stimulated Insulin Secretion

Phenotyping of Individual Pancreatic Islets Locates Genetic Defects in Stimulus Secretion Coupling to Niddm1i Within the Major Diabetes Locus in GK Rats

γ-Interferon Signaling in Pancreatic β-Cells Is Persistent but Can Be Terminated by Overexpression of Suppressor of Cytokine Signaling-1

Transgenic Overexpression of Hepatocyte Growth Factor in the β-Cell Markedly Improves Islet Function and Islet Transplant Outcomes in Mice

p57KIP2 Expression in Normal Islet Cells and in Hyperinsulinism of Infancy

Pathophysiology

Insulin Signal Transduction in Skeletal Muscle From Glucose-Intolerant Relatives With Type 2 Diabetes

Protection From Obesity and Insulin Resistance in Mice Overexpressing Human Apolipoprotein C1

Overfeeding Rapidly Induces Leptin and Insulin Resistance

Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

Plasma Glucose–Lowering Effect of Tramadol in Streptozotocin-Induced Diabetic Rats

Identification of Novel Genes Differentially Expressed in Omental Fat of Obese Subjects and Obese Type 2 Diabetic Patients

Acute 2DG-Induced Glucoprivation or Dexamethasone Abolishes 2DG-Induced Glucoregulatory Responses to Subsequent Glucoprivation

Complications

Effects of Insulin and Antioxidant on Plasma 8-Hydroxyguanine and Tissue 8-Hydroxydeoxyguanosine in Streptozotocin-Induced Diabetic Rats

A Nonlinear Effect of Hyperglycemia and Current Cigarette Smoking Are Major Determinants of the Onset of Microalbuminuria in Type 1 Diabetes

Genetics

Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima Indians

HbA1c Levels Are Genetically Determined Even in Type 1 Diabetes: Evidence From Healthy and Diabetic Twins

A Missense Mutation of Pax4 Gene (R121W) Is Associated With Type 2 Diabetes in Japanese

Brief Genetics Report

Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

Diabetes-Associated HLA-DQ Genes and Birth Weight

Tribute

Bruce R. Zimmerman, md: 1942–2001

Erratum

Erratum

This Issue

Current Issue

Interleukin-1β Stimulation of c-Jun NH₂-Terminal Kinase Activity in Insulin-Secreting Cells: Evidence for Cytoplasmic Restriction

p57^KIP2 Expression in Normal Islet Cells and in Hyperinsulinism of Infancy

HbA_1c Levels Are Genetically Determined Even in Type 1 Diabetes: Evidence From Healthy and Diabetic Twins