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Table of Contents

February 2001; 50 (2)

Perspectives in Diabetes

    • Edwin A.M. Gale

    The Discovery of Type 1 Diabetes

    Diabetes February 2001 50:217-226; doi:10.2337/diabetes.50.2.217

Rapid Publication

    • Mitsuyo Shintani,
    • Yoshihiro Ogawa,
    • Ken Ebihara,
    • Megumi Aizawa-Abe,
    • Fumiko Miyanaga,
    • Kazuhiko Takaya,
    • Tatsuya Hayashi,
    • Gen Inoue,
    • Kiminori Hosoda,
    • Masayasu Kojima,
    • Kenji Kangawa,
    • and Kazuwa Nakao

    Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

    Diabetes February 2001 50:227-232; doi:10.2337/diabetes.50.2.227

Metabolism and Signal Transduction

    • Hong Ruan and
    • Henry J. Pownall

    Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-α Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle

    Diabetes February 2001 50:233-240; doi:10.2337/diabetes.50.2.233
    • Yasuki Higaki,
    • Michael F. Hirshman,
    • Nobuharu Fujii,
    • and Laurie J. Goodyear

    Nitric Oxide Increases Glucose Uptake Through a Mechanism That Is Distinct From the Insulin and Contraction Pathways in Rat Skeletal Muscle

    Diabetes February 2001 50:241-247; doi:10.2337/diabetes.50.2.241
    • Caroline J. Small,
    • Min S. Kim,
    • Sarah A. Stanley,
    • John R.D. Mitchell,
    • Kevin Murphy,
    • David G.A. Morgan,
    • Mohammad A. Ghatei,
    • and Stephen R. Bloom

    Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals

    Diabetes February 2001 50:248-254; doi:10.2337/diabetes.50.2.248
    • Shlomzion Shen,
    • Addy Alt,
    • Efrat Wertheimer,
    • Marina Gartsbein,
    • Toshio Kuroki,
    • Motoi Ohba,
    • Liora Braiman,
    • Sanford R. Sampson,
    • and Tamar Tennenbaum

    PKCδ Activation: A Divergence Point in the Signaling of Insulin and IGF-1—Induced Proliferation of Skin Keratinocytes

    Diabetes February 2001 50:255-264; doi:10.2337/diabetes.50.2.255
    • Jørgen F.P. Wojtaszewski,
    • Pernille Nielsen,
    • Bente Kiens,
    • and Erik A. Richter

    Regulation of Glycogen Synthase Kinase-3 in Human Skeletal Muscle: Effects of Food Intake and Bicycle Exercise

    Diabetes February 2001 50:265-269; doi:10.2337/diabetes.50.2.265

Immunology and Transplantation

    • R. Damaris Molano,
    • Thierry Berney,
    • Hua Li,
    • Pierre Cattan,
    • Antonello Pileggi,
    • Caterina Vizzardelli,
    • Norma S. Kenyon,
    • Camillo Ricordi,
    • Linda C. Burkly,
    • and Luca Inverardi

    Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation

    Diabetes February 2001 50:270-276; doi:10.2337/diabetes.50.2.270
    • Livio Luzi,
    • Gianluca Perseghin,
    • Mathias D. Brendel,
    • Ileana Terruzzi,
    • Alberto Battezzati,
    • Michael Eckhard,
    • Daniel Brandhorst,
    • Heide Brandhorst,
    • Schirin Friemann,
    • Carlo Socci,
    • Valerio Di Carlo,
    • Lucia Piceni Sereni,
    • Stefano Benedini,
    • Antonio Secchi,
    • Guido Pozza,
    • and Reinhard G. Bretzel

    Metabolic Effects of Restoring Partial β-Cell Function After Islet Allotransplantation in Type 1 Diabetic Patients

    Diabetes February 2001 50:277-282; doi:10.2337/diabetes.50.2.277

Islet Studies

    • Libby A. Blair,
    • Monique R. Heitmeier,
    • Anna L. Scarim,
    • Leonard B. Maggi, Jr.,
    • and John A. Corbett

    Double-Stranded RNA—Dependent Protein Kinase Is Not Required for Double-Stranded RNA—Induced Nitric Oxide Synthase Expression or Nuclear Factor-κB Activation by Islets

    Diabetes February 2001 50:283-290; doi:10.2337/diabetes.50.2.283
    • Peter Ronner,
    • C. Maik Naumann,
    • and Edward Friel

    Effects of Glucose and Amino Acids on Free ADP in βHC9 Insulin-Secreting Cells

    Diabetes February 2001 50:291-300; doi:10.2337/diabetes.50.2.291
    • Björn Tyrberg,
    • Jarkko Ustinov,
    • Timo Otonkoski,
    • and Arne Andersson

    Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ

    Diabetes February 2001 50:301-307; doi:10.2337/diabetes.50.2.301
    • Rafael Nesher,
    • Nasim Warwar,
    • Akhtar Khan,
    • Suad Efendic,
    • Erol Cerasi,
    • and Nurit Kaiser

    Defective Stimulus-Secretion Coupling in Islets of Psammomys obesus, an Animal Model for Type 2 Diabetes

    Diabetes February 2001 50:308-314; doi:10.2337/diabetes.50.2.308
    • Isabelle Briaud,
    • Jamie S. Harmon,
    • Cynthia L. Kelpe,
    • Venkatesh Babu G. Segu,
    • and Vincent Poitout

    Lipotoxicity of the Pancreatic β-Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids

    Diabetes February 2001 50:315-321; doi:10.2337/diabetes.50.2.315
    • A. Grimberg,
    • R.J. Ferry, Jr.,
    • A. Kelly,
    • S. Koo-McCoy,
    • K. Polonsky,
    • B. Glaser,
    • M.A. Permutt,
    • L. Aguilar-Bryan,
    • D. Stafford,
    • P.S. Thornton,
    • L. Baker,
    • and Charles A. Stanley

    Dysregulation of Insulin Secretion in Children With Congenital Hyperinsulinism due to Sulfonylurea Receptor Mutations

    Diabetes February 2001 50:322-328; doi:10.2337/diabetes.50.2.322
    • Susanne G. Straub,
    • Karen E. Cosgrove,
    • Carina Ämmälä,
    • Ruth M. Shepherd,
    • Rachel E. O'Brien,
    • Philippa D. Barnes,
    • Na'ama Kuchinski,
    • Joanna C. Chapman,
    • Michela Schaeppi,
    • Benjamin Glaser,
    • Keith J. Lindley,
    • Geoffrey W.G. Sharp,
    • Albert Aynsley-Green,
    • and Mark J. Dunne

    Hyperinsulinism of Infancy: The Regulated Release of Insulin by KATP Channel—Independent Pathways

    Diabetes February 2001 50:329-339; doi:10.2337/diabetes.50.2.329
    • Sue L.F. Chan,
    • Mirna Mourtada,
    • and Noel G. Morgan

    Characterization of a KATP Channel—Independent Pathway Involved in Potentiation of Insulin Secretion by Efaroxan

    Diabetes February 2001 50:340-347; doi:10.2337/diabetes.50.2.340
    • Jane A. Cases,
    • Ilan Gabriely,
    • Xiao Hui Ma,
    • Xiao Man Yang,
    • Tamar Michaeli,
    • Norman Fleischer,
    • Luciano Rossetti,
    • and Nir Barzilai

    Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo

    Diabetes February 2001 50:348-352; doi:10.2337/diabetes.50.2.348
    • Guang Xu,
    • Guim Kwon,
    • Wilhelm S. Cruz,
    • Connie A. Marshall,
    • and Michael L. McDaniel

    Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells

    Diabetes February 2001 50:353-360; doi:10.2337/diabetes.50.2.353
    • Chao Zhao,
    • Marieangela C. Wilson,
    • Franz Schuit,
    • Andrew P. Halestrap,
    • and Guy A. Rutter

    Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

    Diabetes February 2001 50:361-366; doi:10.2337/diabetes.50.2.361

Pathophysiology

    • Nancy Flattem,
    • Kayano Igawa,
    • Masakazu Shiota,
    • Maya G. Emshwiller,
    • Doss W. Neal,
    • and Alan D. Cherrington

    α- and β-Cell Responses to Small Changes in Plasma Glucose in the Conscious Dog

    Diabetes February 2001 50:367-375; doi:10.2337/diabetes.50.2.367
    • Takayuki Masaki,
    • Hironobu Yoshimatsu,
    • Seiichi Chiba,
    • Takeshi Watanabe,
    • and Toshiie Sakata

    Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice

    Diabetes February 2001 50:376-384; doi:10.2337/diabetes.50.2.376
    • Takayuki Masaki,
    • Hironobu Yoshimatsu,
    • Seiichi Chiba,
    • Takeshi Watanabe,
    • and Toshiie Sakata

    Targeted Disruption of Histamine H1-Receptor Attenuates Regulatory Effects of Leptin on Feeding, Adiposity, and UCP Family in Mice

    Diabetes February 2001 50:385-391; doi:10.2337/diabetes.50.2.385
    • Martin G. Bischof,
    • Martin Krssak,
    • Michael Krebs,
    • Elisabeth Bernroider,
    • Harald Stingl,
    • Werner Waldhäusl,
    • and Michael Roden

    Effects of Short-Term Improvement of Insulin Treatment and Glycemia on Hepatic Glycogen Metabolism in Type 1 Diabetes

    Diabetes February 2001 50:392-398; doi:10.2337/diabetes.50.2.392
    • Andrea L. Hevener,
    • Richard N. Bergman,
    • and Casey M. Donovan

    Hypoglycemic Detection Does Not Occur in the Hepatic Artery or Liver: Findings Consistent With a Portal Vein Glucosensor Locus

    Diabetes February 2001 50:399-403; doi:10.2337/diabetes.50.2.399
    • Betty A. Maddux,
    • Wendy See,
    • John C. Lawrence, Jr.,
    • Amy L. Goldfine,
    • Ira D. Goldfine,
    • and Joseph L. Evans

    Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

    Diabetes February 2001 50:404-410; doi:10.2337/diabetes.50.2.404
    • Ji-Ming Ye,
    • Patrick J. Doyle,
    • Miguel A. Iglesias,
    • David G. Watson,
    • Gregory J. Cooney,
    • and Edward W. Kraegen

    Peroxisome Proliferator—Activated Receptor (PPAR)-α Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats: Comparison With PPAR-γ Activation

    Diabetes February 2001 50:411-417; doi:10.2337/diabetes.50.2.411
    • Cheol S. Choi,
    • Felix N. Lee,
    • and Jang H. Youn

    Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats

    Diabetes February 2001 50:418-424; doi:10.2337/diabetes.50.2.418
    • Timothy J. Kowalski,
    • Shun-Mei Liu,
    • Rudolph L. Leibel,
    • and Streamson C. Chua, Jr.

    Transgenic Complementation of Leptin-Receptor Deficiency: I. Rescue of the Obesity/Diabetes Phenotype of LEPR-Null Mice Expressing a LEPR-B Transgene

    Diabetes February 2001 50:425-435; doi:10.2337/diabetes.50.2.425

Complications

    • Robert D. Hoeldtke,
    • Kimberly D. Bryner,
    • Gabriella G. Horvath,
    • Robert W. Phares,
    • Lance F. Broy,
    • and Gerald R. Hobbs

    Redistribution of Sudomotor Responses Is an Early Sign of Sympathetic Dysfunction in Type 1 Diabetes

    Diabetes February 2001 50:436-443; doi:10.2337/diabetes.50.2.436
    • Izumi Suzuma,
    • Yasuaki Hata,
    • Allen Clermont,
    • Frank Pokras,
    • Susan L. Rook,
    • Kiyoshi Suzuma,
    • Edward P. Feener,
    • and Lloyd Paul Aiello

    Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2: Potential Mechanisms for Exacerbation of Diabetic Retinopathy by Hypertension

    Diabetes February 2001 50:444-454; doi:10.2337/diabetes.50.2.444
    • Ü. Deniz Dinçer,
    • Keshore R. Bidasee,
    • Şahika Güner,
    • Ayin Tay,
    • A. Tanju Özçelikay,
    • and V. Melih Altan

    The Effect of Diabetes on Expression of β1-, β2-, and β3-Adrenoreceptors in Rat Hearts

    Diabetes February 2001 50:455-461; doi:10.2337/diabetes.50.2.455
    • Amandine Harbis,
    • Catherine Defoort,
    • Hervé Narbonne,
    • Christine Juhel,
    • Michèle Senft,
    • Christian Latgé,
    • Blandine Delenne,
    • Henri Portugal,
    • Catherine Atlan-Gepner,
    • Bernard Vialettes,
    • and Denis Lairon

    Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride—Rich Lipoproteins in Healthy Subjects During the Postprandial Period

    Diabetes February 2001 50:462-469; doi:10.2337/diabetes.50.2.462

Epidemiology

    • Carla J. Greenbaum,
    • David Cuthbertson,
    • and Jeffrey P. Krischer

    Type 1 Diabetes Manifested Solely by 2-h Oral Glucose Tolerance Test Criteria

    Diabetes February 2001 50:470-476; doi:10.2337/diabetes.50.2.470

Erratum

  • Erratum

    Diabetes February 2001 50:477; doi:10.2337/diabetes.50.2.477

  • Erratum

    Diabetes February 2001 50:478; doi:10.2337/diabetes.50.2.478
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This Issue

February 2001; 50 (2)
  1. Perspectives in Diabetes
  2. Rapid Publication
  3. Metabolism and Signal Transduction
  4. Immunology and Transplantation
  5. Islet Studies
  6. Pathophysiology
  7. Complications
  8. Epidemiology
  9. Erratum

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