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Table of Contents

March 2001; 50 (3)

Immunology and Transplantation

    • Simona DeFranco,
    • Sara Bonissoni,
    • Franco Cerutti,
    • Gianni Bona,
    • Flavia Bottarel,
    • Francesco Cadario,
    • Alfredo Brusco,
    • Giuseppe Loffredo,
    • Ivana Rabbone,
    • Andrea Corrias,
    • Claudio Pignata,
    • Ugo Ramenghi,
    • and Umberto Dianzani

    Defective Function of Fas in Patients With Type 1 Diabetes Associated With Other Autoimmune Diseases

    Diabetes March 2001 50:483-488; doi:10.2337/diabetes.50.3.483
    • Per-Ola Carlsson,
    • Fredrik Palm,
    • Arne Andersson,
    • and Per Liss

    Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site

    Diabetes March 2001 50:489-495; doi:10.2337/diabetes.50.3.489
    • Paolo Fiorina,
    • Ennio La Rocca,
    • Massimo Venturini,
    • Fabio Minicucci,
    • Isabella Fermo,
    • Rita Paroni,
    • Armando D’Angelo,
    • Marisa Sblendido,
    • Valerio Di Carlo,
    • Marco Cristallo,
    • Alessandro Del Maschio,
    • Guido Pozza,
    • and Antonio Secchi

    Effects of Kidney-Pancreas Transplantation on Atherosclerotic Risk Factors and Endothelial Function in Patients With Uremia and Type 1 Diabetes

    Diabetes March 2001 50:496-501; doi:10.2337/diabetes.50.3.496
    • Larry J. Bischof,
    • Cyrus C. Martin,
    • Christina A. Svitek,
    • Beth T. Stadelmaier,
    • Lauri A. Hornbuckle,
    • Joshua K. Goldman,
    • James K. Oeser,
    • John C. Hutton,
    • and Richard M. O’Brien

    Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: Correlation With Fusion Gene Expression in the Islet-Derived βTC-3 and Hamster Insulinoma Tumor Cell Lines

    Diabetes March 2001 50:502-514; doi:10.2337/diabetes.50.3.502
    • Terence Flotte,
    • Anupam Agarwal,
    • Jianming Wang,
    • Sihong Song,
    • Elizabeth S. Fenjves,
    • Luca Inverardi,
    • Kye Chesnut,
    • Sandra Afione,
    • Scott Loiler,
    • Clive Wasserfall,
    • Matthias Kapturczak,
    • Tamir Ellis,
    • Harry Nick,
    • and Mark Atkinson

    Efficient Ex Vivo Transduction of Pancreatic Islet Cells With Recombinant Adeno-Associated Virus Vectors

    Diabetes March 2001 50:515-520; doi:10.2337/diabetes.50.3.515
    • Henryk Zulewski,
    • Elizabeth J. Abraham,
    • Melissa J. Gerlach,
    • Philip B. Daniel,
    • Wolfgang Moritz,
    • Beat Müller,
    • Mario Vallejo,
    • Melissa K. Thomas,
    • and Joel F. Habener

    Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

    Diabetes March 2001 50:521-533; doi:10.2337/diabetes.50.3.521
    • Jing Wang,
    • Jun Xu,
    • Jennifer Finnerty,
    • Machi Furuta,
    • Donald F. Steiner,
    • and C. Bruce Verchere

    The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH2-Terminal Cleavage Site

    Diabetes March 2001 50:534-539; doi:10.2337/diabetes.50.3.534
    • Françoise C. Jonkers and
    • Jean-Claude Henquin

    Measurements of Cytoplasmic Ca2+ in Islet Cell Clusters Show That Glucose Rapidly Recruits β-Cells and Gradually Increases the Individual Cell Response

    Diabetes March 2001 50:540-550; doi:10.2337/diabetes.50.3.540
    • Anne Hoorens,
    • Geert Stangé,
    • Dejan Pavlovic,
    • and Daniel Pipeleers

    Distinction Between Interleukin-1–Induced Necrosis and Apoptosis of Islet Cells

    Diabetes March 2001 50:551-557; doi:10.2337/diabetes.50.3.551

Pathophysiology

    • Sylvain Cardin,
    • Patricia A. Jackson,
    • Dale S. Edgerton,
    • Doss W. Neal,
    • Christopher S. Coffey,
    • and Alan D. Cherrington

    Effect of Vagal Cooling on the Counterregulatory Response to Hypoglycemia Induced by a Low Dose of Insulin in the Conscious Dog

    Diabetes March 2001 50:558-564; doi:10.2337/diabetes.50.3.558
    • Adrian Vella,
    • Pankaj Shah,
    • Rita Basu,
    • Ananda Basu,
    • Michael Camilleri,
    • Frederick W. Schwenk,
    • Jens J. Holst,
    • and Robert A. Rizza

    Effect of Glucagon-Like Peptide-1(7-36)-Amide on Initial Splanchnic Glucose Uptake and Insulin Action in Humans With Type 1 Diabetes

    Diabetes March 2001 50:565-572; doi:10.2337/diabetes.50.3.565
    • Takehide Ogihara,
    • Tomoichiro Asano,
    • Katsuyuki Ando,
    • Yuko Chiba,
    • Nobuo Sekine,
    • Hideyuki Sakoda,
    • Motonobu Anai,
    • Yukiko Onishi,
    • Midori Fujishiro,
    • Hiraku Ono,
    • Nobuhiro Shojima,
    • Kouichi Inukai,
    • Yasushi Fukushima,
    • Masatoshi Kikuchi,
    • and Toshiro Fujita

    Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet–Fed Rats

    Diabetes March 2001 50:573-583; doi:10.2337/diabetes.50.3.573
    • Yukio Ikeda,
    • Grith S. Olsen,
    • Ehud Ziv,
    • Lone L. Hansen,
    • Anna K. Busch,
    • Bo F. Hansen,
    • Eleazar Shafrir,
    • and Luitgard Mosthaf-Seedorf

    Cellular Mechanism of Nutritionally Induced Insulin Resistance in Psammomys Obesus: Overexpression of Protein Kinase Cε in Skeletal Muscle Precedes the Onset of Hyperinsulinemia and Hyperglycemia

    Diabetes March 2001 50:584-592; doi:10.2337/diabetes.50.3.584
    • Joseph T. Brozinick, Jr.,
    • Scott C. McCoid,
    • Thomas H. Reynolds,
    • Nancy A. Nardone,
    • Diane M. Hargrove,
    • Ralph W. Stevenson,
    • Samuel W. Cushman,
    • and E. Michael Gibbs

    GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

    Diabetes March 2001 50:593-600; doi:10.2337/diabetes.50.3.593
    • Roberto Fabris,
    • Enzo Nisoli,
    • Anna Maria Lombardi,
    • Cristina Tonello,
    • Roberto Serra,
    • Marnie Granzotto,
    • Isabelle Cusin,
    • Françoise Rohner-Jeanrenaud,
    • Giovanni Federspil,
    • Michele O. Carruba,
    • and Roberto Vettor

    Preferential Channeling of Energy Fuels Toward Fat Rather Than Muscle During High Free Fatty Acid Availability in Rats

    Diabetes March 2001 50:601-608; doi:10.2337/diabetes.50.3.601
    • Tina Vilsbøll,
    • Thure Krarup,
    • Carolyn F. Deacon,
    • Sten Madsbad,
    • and Jens J. Holst

    Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients

    Diabetes March 2001 50:609-613; doi:10.2337/diabetes.50.3.609
    • Louis Pérusse,
    • Treva Rice,
    • Yvon C. Chagnon,
    • Jean-Pierre Després,
    • Simone Lemieux,
    • Sonia Roy,
    • Michel Lacaille,
    • My-Ann Ho-Kim,
    • Monique Chagnon,
    • Michael A. Province,
    • D.C. Rao,
    • and Claude Bouchard

    A Genome-Wide Scan for Abdominal Fat Assessed by Computed Tomography in the Québec Family Study

    Diabetes March 2001 50:614-621; doi:10.2337/diabetes.50.3.614
    • Masakazu Shiota,
    • Catherine Postic,
    • Yuka Fujimoto,
    • Thomas L. Jetton,
    • Kathryn Dixon,
    • Danhua Pan,
    • Joseph Grimsby,
    • Joseph F. Grippo,
    • Mark A. Magnuson,
    • and Alan D. Cherrington

    Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes

    Diabetes March 2001 50:622-629; doi:10.2337/diabetes.50.3.622

Complications

    • C. Hauerslev Foss,
    • E. Vestbo,
    • A. Frøland,
    • H.J. Gjessing,
    • C.E. Mogensen,
    • and E.M. Damsgaard

    Autonomic Neuropathy in Nondiabetic Offspring of Type 2 Diabetic Subjects Is Associated With Urinary Albumin Excretion Rate and 24-h Ambulatory Blood Pressure: The Fredericia Study

    Diabetes March 2001 50:630-636; doi:10.2337/diabetes.50.3.630
    • Norbert Vaessen,
    • Peter Heutink,
    • Joop A. Janssen,
    • Jacqueline C. M. Witteman,
    • Leon Testers,
    • Albert Hofman,
    • Steven W. J. Lamberts,
    • Ben A. Oostra,
    • Huibert A. P. Pols,
    • and Cornelia M. van Duijn

    A Polymorphism in the Gene for IGF-I: Functional Properties and Risk for Type 2 Diabetes and Myocardial Infarction

    Diabetes March 2001 50:637-642; doi:10.2337/diabetes.50.3.637
    • Lawrence W. Castellani,
    • Aimie M. Goto,
    • and Aldons J. Lusis

    Studies With Apolipoprotein A-II Transgenic Mice Indicate a Role for HDLs in Adiposity and Insulin Resistance

    Diabetes March 2001 50:643-651; doi:10.2337/diabetes.50.3.643
    • Helen M. Colhoun,
    • Leo M. Scheek,
    • Michael B. Rubens,
    • Teus Van Gent,
    • S. Richard Underwood,
    • John H. Fuller,
    • and Arie Van Tol

    Lipid Transfer Protein Activities in Type 1 Diabetic Patients Without Renal Failure and Nondiabetic Control Subjects and Their Association With Coronary Artery Calcification

    Diabetes March 2001 50:652-659; doi:10.2337/diabetes.50.3.652
    • Sophie Élise Michaud and
    • Geneviève Renier

    Direct Regulatory Effect of Fatty Acids on Macrophage Lipoprotein Lipase: Potential Role of PPARs

    Diabetes March 2001 50:660-666; doi:10.2337/diabetes.50.3.660
    • Domenica Altavilla,
    • Antonino Saitta,
    • Domenico Cucinotta,
    • Mariarosaria Galeano,
    • Barbara Deodato,
    • Michele Colonna,
    • Valerio Torre,
    • Giuseppina Russo,
    • Aurora Sardella,
    • Giuseppe Urna,
    • Giuseppe M. Campo,
    • Vittorio Cavallari,
    • Giovanni Squadrito,
    • and Francesco Squadrito

    Inhibition of Lipid Peroxidation Restores Impaired Vascular Endothelial Growth Factor Expression and Stimulates Wound Healing and Angiogenesis in the Genetically Diabetic Mouse

    Diabetes March 2001 50:667-674; doi:10.2337/diabetes.50.3.667

Genetics

    • Alex Parker,
    • Joanne Meyer,
    • Steve Lewitzky,
    • Jean S. Rennich,
    • Gayun Chan,
    • Jeffrey D. Thomas,
    • Marju Orho-Melander,
    • Mikko Lehtovirta,
    • Carol Forsblom,
    • Auli Hyrkkö,
    • Martin Carlsson,
    • Cecilia Lindgren,
    • and Leif C. Groop

    A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11

    Diabetes March 2001 50:675-680; doi:10.2337/diabetes.50.3.675
    • Marshall A. Permutt,
    • Jonathon C. Wasson,
    • Brian K. Suarez,
    • Jennifer Lin,
    • Jeffrey Thomas,
    • Joanne Meyer,
    • Steve Lewitzky,
    • Jean S. Rennich,
    • Alex Parker,
    • Laura DuPrat,
    • Sanchit Maruti,
    • Susan Chayen,
    • and Benjamin Glaser

    A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

    Diabetes March 2001 50:681-685; doi:10.2337/diabetes.50.3.681

Brief Genetics Report

    • Jian’an Luan,
    • Paul O. Browne,
    • Anne-Helen Harding,
    • David J. Halsall,
    • Stephen O’Rahilly,
    • V.K. Krishna Chatterjee,
    • and Nicholas J. Wareham

    Evidence for Gene-Nutrient Interaction at the PPARγ Locus

    Diabetes March 2001 50:686-689; doi:10.2337/diabetes.50.3.686
    • Lars Hansen,
    • Björn Zethelius,
    • Lars Berglund,
    • Richard Reneland,
    • Torben Hansen,
    • Christian Berne,
    • Hans Lithell,
    • Brian A. Hemmings,
    • and Oluf Pedersen

    In Vitro and In Vivo Studies of a Naturally Occurring Variant of the Human p85α Regulatory Subunit of the Phosphoinositide 3-Kinase: Inhibition of Protein Kinase B and Relationships With Type 2 Diabetes, Insulin Secretion, Glucose Disappearance Constant, and Insulin Sensitivity

    Diabetes March 2001 50:690-693; doi:10.2337/diabetes.50.3.690
    • Laura del Bosque-Plata,
    • Joseph Lin,
    • Yukio Horikawa,
    • Peter E.H. Schwarz,
    • Nancy J. Cox,
    • Naoko Iwasaki,
    • Makiko Ogata,
    • Yasuhiko Iwamoto,
    • Michael S. German,
    • and Graeme I. Bell

    Mutations in the Coding Region of the Neurogenin 3 Gene (NEUROG3) Are Not a Common Cause of Maturity-Onset Diabetes of the Young in Japanese Subjects

    Diabetes March 2001 50:694-696; doi:10.2337/diabetes.50.3.694
    • S. John Weisnagel,
    • Tuomo Rankinen,
    • André Nadeau,
    • D.C. Rao,
    • Yvon C. Chagnon,
    • Louis Pérusse,
    • and Claude Bouchard

    Decreased Fasting and Oral Glucose Stimulated C-peptide in Nondiabetic Subjects With Sequence Variants in the Sulfonylurea Receptor 1 Gene

    Diabetes March 2001 50:697-702; doi:10.2337/diabetes.50.3.697
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This Issue

March 2001; 50 (3)
  1. Immunology and Transplantation
  2. Pathophysiology
  3. Complications
  4. Genetics
  5. Brief Genetics Report

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