Table of Contents

Rapid Publication

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- Matthias Tschöp,
- Christian Weyer,
- P. Antonio Tataranni,
- Viswanath Devanarayan,
- Eric Ravussin,
- and Mark L. Heiman
Circulating Ghrelin Levels Are Decreased in Human Obesity
Diabetes April 2001 50:707-709; doi:10.2337/diabetes.50.4.707
Select this article
- Edmond A. Ryan,
- Jonathan R.T. Lakey,
- Ray V. Rajotte,
- Gregory S. Korbutt,
- Tatsuya Kin,
- Sharleen Imes,
- Alex Rabinovitch,
- John F. Elliott,
- David Bigam,
- Norman M. Kneteman,
- Garth L. Warnock,
- Ingrid Larsen,
- and A.M. James Shapiro
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Diabetes April 2001 50:710-719; doi:10.2337/diabetes.50.4.710

Metabolism and Signal Transduction

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- Reza Halse,
- Sylvie M. Bonavaud,
- Jane L. Armstrong,
- James G. McCormack,
- and Stephen J. Yeaman
Control of Glycogen Synthesis by Glucose, Glycogen, and Insulin in Cultured Human Muscle Cells
Diabetes April 2001 50:720-726; doi:10.2337/diabetes.50.4.720
Select this article
- Vincent Rigalleau,
- Christophe Binnert,
- Kaori Minehira,
- Nathalie Stefanoni,
- Phillippe Schneiter,
- Emmanuel Henchoz,
- Oscar Matzinger,
- Christine Cayeux,
- Eric Jéquier,
- and Luc Tappy
In Normal Men, Free Fatty Acids Reduce Peripheral but Not Splanchnic Glucose Uptake
Diabetes April 2001 50:727-732; doi:10.2337/diabetes.50.4.727
Select this article
- Hideo Makimura,
- Tooru M. Mizuno,
- Xue-Jun Yang,
- Jeff Silverstein,
- Joe Beasley,
- and Charles V. Mobbs
Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting
Diabetes April 2001 50:733-739; doi:10.2337/diabetes.50.4.733
Select this article
- Martine Croset,
- Fabienne Rajas,
- Carine Zitoun,
- Jean-Marc Hurot,
- Sandrine Montano,
- and Gilles Mithieux
Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ
Diabetes April 2001 50:740-746; doi:10.2337/diabetes.50.4.740
Select this article
- Niels Moller,
- Robert A. Rizza,
- G. Charles Ford,
- and K. Sreekumaran Nair
Assessment of Postabsorptive Renal Glucose Metabolism in Humans With Multiple Glucose Tracers
Diabetes April 2001 50:747-751; doi:10.2337/diabetes.50.4.747

Immunology and Transplantation

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- Roberto Mallone,
- Erika Ortolan,
- Germano Baj,
- Ada Funaro,
- Sara Giunti,
- Emma Lillaz,
- Franca Saccucci,
- Maurizio Cassader,
- Paolo Cavallo-Perin,
- and Fabio Malavasi
Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 Diabetes: Immunological and Genetic Characterization
Diabetes April 2001 50:752-762; doi:10.2337/diabetes.50.4.752
Select this article
- Priscilla P.L. Chiu,
- David V. Serreze,
- and Jayne S. Danska
Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice
Diabetes April 2001 50:763-770; doi:10.2337/diabetes.50.4.763
Select this article
- Arno Hänninen,
- Andrea Braakhuis,
- William R. Heath,
- and Leonard C. Harrison
Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route
Diabetes April 2001 50:771-775; doi:10.2337/diabetes.50.4.771

Islet Studies

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- Robert Ritzel,
- Miriam Schulte,
- Niels Pørksen,
- Markus S. Nauck,
- Jens J. Holst,
- Claus Juhl,
- Winfried März,
- Ole Schmitz,
- Wolff H. Schmiegel,
- and Michael A. Nauck
Glucagon-Like Peptide 1 Increases Secretory Burst Mass of Pulsatile Insulin Secretion in Patients With Type 2 Diabetes and Impaired Glucose Tolerance
Diabetes April 2001 50:776-784; doi:10.2337/diabetes.50.4.776
Select this article
- Hongxiang Hui,
- Chris Wright,
- and Riccardo Perfetti
Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells
Diabetes April 2001 50:785-796; doi:10.2337/diabetes.50.4.785
Select this article
- Alexander M. Efanov,
- Sergei V. Zaitsev,
- Hans-Juergen Mest,
- Achim Raap,
- Ioulia B. Appelskog,
- Olof Larsson,
- Per-Olof Berggren,
- and Suad Efendic
The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of K_ATP Channel Activity
Diabetes April 2001 50:797-802; doi:10.2337/diabetes.50.4.797
Select this article
- Nathalie Lameloise,
- Patrick Muzzin,
- Marc Prentki,
- and Françoise Assimacopoulos-Jeannet
Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
Diabetes April 2001 50:803-809; doi:10.2337/diabetes.50.4.803

Pathophysiology

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- Guenther Boden,
- Xinhua Chen,
- Edwin Capulong,
- and Maria Mozzoli
Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes
Diabetes April 2001 50:810-816; doi:10.2337/diabetes.50.4.810
Select this article
- Jing He,
- Simon Watkins,
- and David E. Kelley
Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
Diabetes April 2001 50:817-823; doi:10.2337/diabetes.50.4.817
Select this article
- Vara Prasad Manchem,
- Ira D. Goldfine,
- Ronald A. Kohanski,
- Cristina P. Cristobal,
- Robert T. Lum,
- Steven R. Schow,
- Songyuan Shi,
- Wayne R. Spevak,
- Edgardo Laborde,
- Deborah K. Toavs,
- Hugo O. Villar,
- Michael M. Wick,
- and Michael R. Kozlowski
A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
Diabetes April 2001 50:824-830; doi:10.2337/diabetes.50.4.824
Select this article
- Benedetta V. Costanzo,
- Vincenzo Trischitta,
- Rosa Di Paola,
- Daniela Spampinato,
- Antonio Pizzuti,
- Riccardo Vigneri,
- and Lucia Frittitta
The Q Allele Variant (GLN¹²¹) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS¹²¹)
Diabetes April 2001 50:831-836; doi:10.2337/diabetes.50.4.831

Complications

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- Per Løgstrup Poulsen,
- Eva Ebbehøj,
- Hanne Arildsen,
- Søren Tang Knudsen,
- Klaus Würgler Hansen,
- Henning Mølgaard,
- and Carl Erik Mogensen
Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients
Diabetes April 2001 50:837-842; doi:10.2337/diabetes.50.4.837
Select this article
- The European Study for the Prevention of Renal Disease in Type 1 Diabetes ESPRIT Study Group
Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With Albuminuria: The European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)
Diabetes April 2001 50:843-850; doi:10.2337/diabetes.50.4.843
Select this article
- Lucy A. Suzuki,
- Martin Poot,
- Ross G. Gerrity,
- and Karin E. Bornfeldt
Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis: Lack of Direct Growth-Promoting Effects of High Glucose Levels
Diabetes April 2001 50:851-860; doi:10.2337/diabetes.50.4.851
Select this article
- Lynne E. Wagenknecht,
- Donald W. Bowden,
- J. Jeffrey Carr,
- Carl D. Langefeld,
- Barry I. Freedman,
- and Stephen S. Rich
Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes
Diabetes April 2001 50:861-866; doi:10.2337/diabetes.50.4.861
Select this article
- Atsushi Otani,
- Hitoshi Takagi,
- Hideyasu Oh,
- Shinji Koyama,
- and Yoshihito Honda
Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells
Diabetes April 2001 50:867-875; doi:10.2337/diabetes.50.4.867

Genetics

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- Michael Stumvoll,
- Hans Günther Wahl,
- Klaus Löblein,
- Regine Becker,
- Fausto Machicao,
- Stephan Jacob,
- and Hans Häring
Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ₂ Gene Is Associated With Increased Antilipolytic Insulin Sensitivity
Diabetes April 2001 50:876-881; doi:10.2337/diabetes.50.4.876

Brief Genetics Report

Select this article
- Michael Stumvoll,
- Andreas Fritsche,
- Annette Volk,
- Norbert Stefan,
- Alexander Madaus,
- Elke Maerker,
- Anna Teigeler,
- Matthias Koch,
- Fausto Machicao,
- and Hans Häring
The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans
Diabetes April 2001 50:882-885; doi:10.2337/diabetes.50.4.882
Select this article
- Julie A. Douglas,
- Michael R. Erdos,
- Richard M. Watanabe,
- Andi Braun,
- Cristy L. Johnston,
- Paul Oeth,
- Karen L. Mohlke,
- Timo T. Valle,
- Christian Ehnholm,
- Thomas A. Buchanan,
- Richard N. Bergman,
- Francis S. Collins,
- Michael Boehnke,
- and Jaakko Tuomilehto
The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant: Association With Type 2 Diabetes and Trait Differences
Diabetes April 2001 50:886-890; doi:10.2337/diabetes.50.4.886
Select this article
- Hiroyuki Mori,
- Hiroshi Ikegami,
- Yoshihiko Kawaguchi,
- Susumu Seino,
- Norihide Yokoi,
- Jun Takeda,
- Ituro Inoue,
- Yutaka Seino,
- Koichiro Yasuda,
- Toshiaki Hanafusa,
- Kazuya Yamagata,
- Takuya Awata,
- Takashi Kadowaki,
- Kazuo Hara,
- Nobuhiro Yamada,
- Takanari Gotoda,
- Naoko Iwasaki,
- Yasuhiko Iwamoto,
- Tokio Sanke,
- Kishio Nanjo,
- Yoshitomo Oka,
- Akira Matsutani,
- Eiichi Maeda,
- and Masato Kasuga
The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes
Diabetes April 2001 50:891-894; doi:10.2337/diabetes.50.4.891
Select this article
- Juan Diez,
- Yongsoo Park,
- Markus Zeller,
- Douglas Brown,
- David Garza,
- Camillo Ricordi,
- John Hutton,
- George S. Eisenbarth,
- and Alberto Pugliese
Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen
Diabetes April 2001 50:895-900; doi:10.2337/diabetes.50.4.895
Select this article
- P. Antonio Tataranni,
- Leslie Baier,
- Chris Jenkinson,
- Inge Harper,
- Angelo Del Parigi,
- and Clifton Bogardus
A Ser311Cys Mutation in the Human Dopamine Receptor D2 Gene Is Associated With Reduced Energy Expenditure
Diabetes April 2001 50:901-904; doi:10.2337/diabetes.50.4.901

Letter to the Editor

Select this article
- John E. Gerich
Measurements of Renal Glucose Release
Diabetes April 2001 50:905; doi:10.2337/diabetes.50.4.905

Diabetes

Rapid Publication

Circulating Ghrelin Levels Are Decreased in Human Obesity

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

Metabolism and Signal Transduction

Control of Glycogen Synthesis by Glucose, Glycogen, and Insulin in Cultured Human Muscle Cells

In Normal Men, Free Fatty Acids Reduce Peripheral but Not Splanchnic Glucose Uptake

Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting

Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ

Assessment of Postabsorptive Renal Glucose Metabolism in Humans With Multiple Glucose Tracers

Immunology and Transplantation

Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 Diabetes: Immunological and Genetic Characterization

Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice

Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route

Islet Studies

Glucagon-Like Peptide 1 Increases Secretory Burst Mass of Pulsatile Insulin Secretion in Patients With Type 2 Diabetes and Impaired Glucose Tolerance

Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells

The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of KATP Channel Activity

Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?

Pathophysiology

Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes

Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity

A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo

The Q Allele Variant (GLN121) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS121)

Complications

Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients

Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With Albuminuria: The European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)

Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis: Lack of Direct Growth-Promoting Effects of High Glucose Levels

Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes

Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells

Genetics

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

Brief Genetics Report

The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant: Association With Type 2 Diabetes and Trait Differences

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen

A Ser311Cys Mutation in the Human Dopamine Receptor D2 Gene Is Associated With Reduced Energy Expenditure

Letter to the Editor

Measurements of Renal Glucose Release

This Issue

Current Issue

The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of K_ATP Channel Activity

The Q Allele Variant (GLN¹²¹) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS¹²¹)

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ₂ Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes