Table of Contents

Rapid Publication

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- Alessandra K. Cardozo,
- Mogens Kruhøffer,
- Ruth Leeman,
- Torben Ørntoft,
- and Décio L. Eizirik
Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays
Diabetes May 2001 50:909-920; doi:10.2337/diabetes.50.5.909
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- Nicolas Musi,
- Nobuharu Fujii,
- Michael F. Hirshman,
- Ingvar Ekberg,
- Sven Fröberg,
- Olle Ljungqvist,
- Anders Thorell,
- and Laurie J. Goodyear
AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise
Diabetes May 2001 50:921-927; doi:10.2337/diabetes.50.5.921
Select this article
- Jane C. Lee,
- Stewart B. Smith,
- Hirotaka Watada,
- Joseph Lin,
- David Scheel,
- Juehu Wang,
- Raghavendra G. Mirmira,
- and Michael S. German
Regulation of the Pancreatic Pro-Endocrine Gene Neurogenin3
Diabetes May 2001 50:928-936; doi:10.2337/diabetes.50.5.928
Select this article
- Pamela A. Lochhead,
- Matthew Coghlan,
- Simon Q.J. Rice,
- and Calum Sutherland
Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression
Diabetes May 2001 50:937-946; doi:10.2337/diabetes.50.5.937

Metabolism and Signal Transduction

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- Bo Ahlman,
- Michael Charlton,
- Aizhong Fu,
- Carole Berg,
- Peter O’Brien,
- and K. Sreekumaran Nair
Insulin’s Effect on Synthesis Rates of Liver Proteins: A Swine Model Comparing Various Precursors of Protein Synthesis
Diabetes May 2001 50:947-954; doi:10.2337/diabetes.50.5.947
Select this article
- Lisa O’Rourke,
- Steven J. Yeaman,
- and Peter R. Shepherd
Insulin and Leptin Acutely Regulate Cholesterol Ester Metabolism in Macrophages by Novel Signaling Pathways
Diabetes May 2001 50:955-961; doi:10.2337/diabetes.50.5.955

Immunology and Transplantation

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- Agneta Lukinius and
- Olle Korsgren
The Transplanted Fetal Endocrine Pancreas Undergoes an Inherent Sequential Differentiation Similar to That in the Native Pancreas: An Ultrastructural Study in the Pig-to-Mouse Model
Diabetes May 2001 50:962-971; doi:10.2337/diabetes.50.5.962
Select this article
- Barbara J. Whalen,
- Jan Marounek,
- Peter Weiser,
- Michael C. Appel,
- Dale L. Greiner,
- John P. Mordes,
- and Aldo A. Rossini
BB Rat Thymocytes Cultured in the Presence of Islets Lose Their Ability to Transfer Autoimmune Diabetes
Diabetes May 2001 50:972-979; doi:10.2337/diabetes.50.5.972
Select this article
- Shimon Efrat,
- David Serreze,
- Anton Svetlanov,
- Cristina M. Post,
- Ellis A. Johnson,
- Kevan Herold,
- and Marshall Horwitz
Adenovirus Early Region 3 (E3) Immunomodulatory Genes Decrease the Incidence of Autoimmune Diabetes in NOD Mice
Diabetes May 2001 50:980-984; doi:10.2337/diabetes.50.5.980
Select this article
- Alessandro Antonelli,
- Germano Baj,
- Piero Marchetti,
- Poupak Fallahi,
- Nicola Surico,
- Cinzia Pupilli,
- Fabio Malavasi,
- and Ele Ferrannini
Human Anti-CD38 Autoantibodies Raise Intracellular Calcium and Stimulate Insulin Release in Human Pancreatic Islets
Diabetes May 2001 50:985-991; doi:10.2337/diabetes.50.5.985

Islet Study

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- Tracie A. Kinard,
- Paulette B. Goforth,
- Qing Tao,
- Mary E. Abood,
- Jeanette Teague,
- and Leslie S. Satin
Chloride Channels Regulate HIT Cell Volume but Cannot Fully Account for Swelling-Induced Insulin Secretion
Diabetes May 2001 50:992-1003; doi:10.2337/diabetes.50.5.992
Select this article
- Francis C. Lynn,
- Nathalie Pamir,
- Eddy H.C. Ng,
- Christopher H.S. McIntosh,
- Timothy J. Kieffer,
- and Raymond A. Pederson
Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats
Diabetes May 2001 50:1004-1011; doi:10.2337/diabetes.50.5.1004
Select this article
- Hiroshi Yamada,
- Masato Otsuka,
- Mitsuko Hayashi,
- Shuuichi Nakatsuka,
- Kazuyuki Hamaguchi,
- Akitsugu Yamamoto,
- and Yoshinori Moriyama
Ca²⁺-Dependent Exocytosis of l-Glutamate by αTC6, Clonal Mouse Pancreatic α-Cells
Diabetes May 2001 50:1012-1020; doi:10.2337/diabetes.50.5.1012
Select this article
- Diane T. Finegood,
- M. Dawn McArthur,
- David Kojwang,
- Marion J. Thomas,
- Brian G. Topp,
- Thomas Leonard,
- and Robin E. Buckingham
β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats: Rosiglitazone Prevents the Rise in Net Cell Death
Diabetes May 2001 50:1021-1029; doi:10.2337/diabetes.50.5.1021
Select this article
- Bo Ahrén and
- Jens J. Holst
The Cephalic Insulin Response to Meal Ingestion in Humans Is Dependent on Both Cholinergic and Noncholinergic Mechanisms and Is Important for Postprandial Glycemia
Diabetes May 2001 50:1030-1038; doi:10.2337/diabetes.50.5.1030
Select this article
- Domenico Bosco,
- Carmen Gonelle-Gispert,
- Claes B. Wollheim,
- Philippe A. Halban,
- and Dominique G. Rouiller
Increased Intracellular Calcium Is Required for Spreading of Rat Islet β-Cells on Extracellular Matrix
Diabetes May 2001 50:1039-1046; doi:10.2337/diabetes.50.5.1039
Select this article
- Xiao Han,
- Yujie Sun,
- Stephen Scott,
- and David Bleich
Tissue Inhibitor of Metalloproteinase-1 Prevents Cytokine-Mediated Dysfunction and Cytotoxicity in Pancreatic Islets and β-cells
Diabetes May 2001 50:1047-1055; doi:10.2337/diabetes.50.5.1047
Select this article
- P. Mose Larsen,
- S.J. Fey,
- M.R. Larsen,
- A. Nawrocki,
- H.U. Andersen,
- H. Kähler,
- C. Heilmann,
- M.C. Voss,
- P. Roepstorff,
- F. Pociot,
- A.E. Karlsen,
- and J. Nerup
Proteome Analysis of Interleukin-1β–Induced Changes in Protein Expression in Rat Islets of Langerhans
Diabetes May 2001 50:1056-1063; doi:10.2337/diabetes.50.5.1056

Complications

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- Masahiro Emoto,
- Takatoshi Anno,
- Yutaka Sato,
- Katsuya Tanabe,
- Shigeru Okuya,
- Yukio Tanizawa,
- Akira Matsutani,
- and Yoshitomo Oka
Troglitazone Treatment Increases Plasma Vascular Endothelial Growth Factor in Diabetic Patients and Its mRNA in 3T3-L1 Adipocytes
Diabetes May 2001 50:1166-1170; doi:10.2337/diabetes.50.5.1166
Select this article
- Jennifer L. Hall,
- John C. Chatham,
- Hagit Eldar-Finkelman,
- and Gary H. Gibbons
Upregulation of Glucose Metabolism During Intimal Lesion Formation Is Coupled to the Inhibition of Vascular Smooth Muscle Cell Apoptosis: Role of GSK3β
Diabetes May 2001 50:1171-1179; doi:10.2337/diabetes.50.5.1171
Select this article
- Alain Nitenberg,
- Séverine Ledoux,
- Paul Valensi,
- Régis Sachs,
- Jean-Raymond Attali,
- and Isabelle Antony
Impairment of Coronary Microvascular Dilation in Response to Cold Pressor–Induced Sympathetic Stimulation in Type 2 Diabetic Patients With Abnormal Stress Thallium Imaging
Diabetes May 2001 50:1180-1185; doi:10.2337/diabetes.50.5.1180
Select this article
- Kaushik Dutta,
- Deborah A. Podolin,
- Michael B. Davidson,
- and Amy J. Davidoff
Cardiomyocyte Dysfunction in Sucrose-Fed Rats Is Associated With Insulin Resistance
Diabetes May 2001 50:1186-1192; doi:10.2337/diabetes.50.5.1186
Select this article
- Antonio F. Machado,
- Ernest F. Zimmerman,
- David N. Hovland Jr.,
- Robert Weiss,
- and Michael D. Collins
Diabetic Embryopathy in C57BL/6J Mice: Altered Fetal Sex Ratio and Impact of the Splotch Allele
Diabetes May 2001 50:1193-1199; doi:10.2337/diabetes.50.5.1193

Brief Genetics Report

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- Francesco Cucca,
- Frank Dudbridge,
- Miriam Loddo,
- Anna P. Mulargia,
- Rosannna Lampis,
- Efisio Angius,
- Stefano De Virgiliis,
- Bobby P.C. Koeleman,
- Stephen C. Bain,
- Anthony H. Barnett,
- Frances Gilchrist,
- Heather Cordell,
- Ken Welsh,
- and John A. Todd
The HLA-DPB1–Associated Component of the IDDM1 and Its Relationship to the Major Loci HLA-DQB1, -DQA1, and -DRB1
Diabetes May 2001 50:1200-1205; doi:10.2337/diabetes.50.5.1200
Select this article
- Toshihiro Kaga,
- Akio Inui,
- Minoru Okita,
- Akihiro Asakawa,
- Naohiko Ueno,
- Masato Kasuga,
- Mineko Fujimiya,
- Noriyasu Nishimura,
- Rika Dobashi,
- Yasuo Morimoto,
- I-Min Liu,
- and Juei-Tang Cheng
Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding
Diabetes May 2001 50:1206-1210; doi:10.2337/diabetes.50.5.1206
Select this article
- Danièle Dubois-Laforgue,
- Houria Hendel,
- Sophie Caillat-Zucman,
- Jean-François Zagury,
- Cheryl Winkler,
- Christian Boitard,
- and José Timsit
A Common Stromal Cell–Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes
Diabetes May 2001 50:1211-1213; doi:10.2337/diabetes.50.5.1211
Select this article
- Odette Poirier,
- Viviane Nicaud,
- Nathalie Vionnet,
- Ségolène Raoux,
- Lise Tarnow,
- Helen Vlassara,
- Hans-Henrik Parving,
- and François Cambien
Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors: Association Study With Nephropathy in Type 1 Diabetic Patients
Diabetes May 2001 50:1214-1218; doi:10.2337/diabetes.50.5.1214
Select this article
- Sophie Dupont,
- El Habib Hani,
- Corentin Cras-Méneur,
- Frédérique De Matos,
- Stéphane Lobbens,
- Cécile Lecoeur,
- Martine Vaxillaire,
- Raphaël Scharfmann,
- and Philippe Froguel
No Evidence for Linkage or for Diabetes-Associated Mutations in the Activin Type 2B Receptor Gene (ACVR2B) in French Patients With Mature-Onset Diabetes of the Young or Type 2 Diabetes
Diabetes May 2001 50:1219-1221; doi:10.2337/diabetes.50.5.1219

Letter to the Editor

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- Mayer B. Davidson
Status of Research Funded by the American Diabetes Association: Year 2
Diabetes May 2001 50:1222; doi:10.2337/diabetes.50.5.1222

Diabetes

Rapid Publication

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise

Regulation of the Pancreatic Pro-Endocrine Gene Neurogenin3

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

Metabolism and Signal Transduction

Insulin’s Effect on Synthesis Rates of Liver Proteins: A Swine Model Comparing Various Precursors of Protein Synthesis

Insulin and Leptin Acutely Regulate Cholesterol Ester Metabolism in Macrophages by Novel Signaling Pathways

Immunology and Transplantation

The Transplanted Fetal Endocrine Pancreas Undergoes an Inherent Sequential Differentiation Similar to That in the Native Pancreas: An Ultrastructural Study in the Pig-to-Mouse Model

BB Rat Thymocytes Cultured in the Presence of Islets Lose Their Ability to Transfer Autoimmune Diabetes

Adenovirus Early Region 3 (E3) Immunomodulatory Genes Decrease the Incidence of Autoimmune Diabetes in NOD Mice

Human Anti-CD38 Autoantibodies Raise Intracellular Calcium and Stimulate Insulin Release in Human Pancreatic Islets

Islet Study

Chloride Channels Regulate HIT Cell Volume but Cannot Fully Account for Swelling-Induced Insulin Secretion

Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats

Ca2+-Dependent Exocytosis of l-Glutamate by αTC6, Clonal Mouse Pancreatic α-Cells

β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats: Rosiglitazone Prevents the Rise in Net Cell Death

The Cephalic Insulin Response to Meal Ingestion in Humans Is Dependent on Both Cholinergic and Noncholinergic Mechanisms and Is Important for Postprandial Glycemia

Increased Intracellular Calcium Is Required for Spreading of Rat Islet β-Cells on Extracellular Matrix

Tissue Inhibitor of Metalloproteinase-1 Prevents Cytokine-Mediated Dysfunction and Cytotoxicity in Pancreatic Islets and β-cells

Proteome Analysis of Interleukin-1β–Induced Changes in Protein Expression in Rat Islets of Langerhans

Pathophysiology

Overexpressing Human Lipoprotein Lipase in Mouse Skeletal Muscle Is Associated With Insulin Resistance

Altered Nephrogenesis Due to Maternal Diabetes Is Associated With Increased Expression of IGF-II/Mannose-6-Phosphate Receptor in the Fetal Kidney

Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats

Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

Troglitazone Induces GLUT4 Translocation in L6 Myotubes

Effects of Tumor Necrosis Factor-α on Insulin Action in Cultured Human Muscle Cells

Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity

Effect of Acute and Antecedent Hypoglycemia on Sympathetic Neural Activity and Catecholamine Responsiveness in Normal Rats

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes

Effect of Experimental Elevation of Free Fatty Acids on Insulin Secretion and Insulin Sensitivity in Healthy Carriers of the Pro12Ala Polymorphism of the Peroxisome Proliferator–Activated Receptor-γ2 Gene

Isomer-Specific Antidiabetic Properties of Conjugated Linoleic Acid: Improved Glucose Tolerance, Skeletal Muscle Insulin Action, and UCP-2 Gene Expression

Thiazolidinediones Increase Plasma-Adipose Tissue FFA Exchange Capacity and Enhance Insulin-Mediated Control of Systemic FFA Availability

Complications

Troglitazone Treatment Increases Plasma Vascular Endothelial Growth Factor in Diabetic Patients and Its mRNA in 3T3-L1 Adipocytes

Upregulation of Glucose Metabolism During Intimal Lesion Formation Is Coupled to the Inhibition of Vascular Smooth Muscle Cell Apoptosis: Role of GSK3β

Impairment of Coronary Microvascular Dilation in Response to Cold Pressor–Induced Sympathetic Stimulation in Type 2 Diabetic Patients With Abnormal Stress Thallium Imaging

Cardiomyocyte Dysfunction in Sucrose-Fed Rats Is Associated With Insulin Resistance

Diabetic Embryopathy in C57BL/6J Mice: Altered Fetal Sex Ratio and Impact of the Splotch Allele

Brief Genetics Report

The HLA-DPB1–Associated Component of the IDDM1 and Its Relationship to the Major Loci HLA-DQB1, -DQA1, and -DRB1

Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding

A Common Stromal Cell–Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes

Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors: Association Study With Nephropathy in Type 1 Diabetic Patients

No Evidence for Linkage or for Diabetes-Associated Mutations in the Activin Type 2B Receptor Gene (ACVR2B) in French Patients With Mature-Onset Diabetes of the Young or Type 2 Diabetes

Letter to the Editor

Status of Research Funded by the American Diabetes Association: Year 2

This Issue

Current Issue

Ca²⁺-Dependent Exocytosis of l-Glutamate by αTC6, Clonal Mouse Pancreatic α-Cells

Effect of Experimental Elevation of Free Fatty Acids on Insulin Secretion and Insulin Sensitivity in Healthy Carriers of the Pro12Ala Polymorphism of the Peroxisome Proliferator–Activated Receptor-γ₂ Gene