Table of Contents

Rapid Publication

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- Kathrin Maedler,
- Giatgen A. Spinas,
- Roger Lehmann,
- Pavel Sergeev,
- Markus Weber,
- Adriano Fontana,
- Nurit Kaiser,
- and Marc Y. Donath
Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets
Diabetes August 2001 50:1683-1690; doi:10.2337/diabetes.50.8.1683
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- Suheir Assady,
- Gila Maor,
- Michal Amit,
- Joseph Itskovitz-Eldor,
- Karl L. Skorecki,
- and Maty Tzukerman
Insulin Production by Human Embryonic Stem Cells
Diabetes August 2001 50:1691-1697; doi:10.2337/diabetes.50.8.1691
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- Valérie F. Duvivier-Kali,
- Abdulkadir Omer,
- Richard J. Parent,
- John J. O’Neil,
- and Gordon C. Weir
Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane
Diabetes August 2001 50:1698-1705; doi:10.2337/diabetes.50.8.1698
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- Jennifer Embury,
- Dagmar Klein,
- Antonello Pileggi,
- Melina Ribeiro,
- Sundararajan Jayaraman,
- R. Damaris Molano,
- Christopher Fraker,
- Norma Kenyon,
- Camillo Ricordi,
- Luca Inverardi,
- and Ricardo L. Pastori
Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets
Diabetes August 2001 50:1706-1713; doi:10.2337/diabetes.50.8.1706
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- David E. Cummings,
- Jonathan Q. Purnell,
- R. Scott Frayo,
- Karin Schmidova,
- Brent E. Wisse,
- and David S. Weigle
A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans
Diabetes August 2001 50:1714-1719; doi:10.2337/diabetes.50.8.1714

Metabolism and Signal Transduction

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- Rémy Burcelin,
- Anabela Da Costa,
- Daniel Drucker,
- and Bernard Thorens
Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor
Diabetes August 2001 50:1720-1728; doi:10.2337/diabetes.50.8.1720
Select this article
- Katalin Kelemen,
- Dale R. Wegmann,
- and John C. Hutton
T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse
Diabetes August 2001 50:1729-1734; doi:10.2337/diabetes.50.8.1729
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- Liping Yu,
- David D. Cuthbertson,
- Noel Maclaren,
- Richard Jackson,
- Jerry P. Palmer,
- Tihamer Orban,
- George S. Eisenbarth,
- and Jeffrey P. Krischer
Expression of GAD65 and Islet Cell Antibody (ICA512) Autoantibodies Among Cytoplasmic ICA+ Relatives Is Associated With Eligibility for the Diabetes Prevention Trial−Type 1
Diabetes August 2001 50:1735-1740; doi:10.2337/diabetes.50.8.1735
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- Martine I. Darville and
- Décio L. Eizirik
Cytokine Induction of Fas Gene Expression in Insulin-Producing Cells Requires the Transcription Factors NF-κB and C/EBP
Diabetes August 2001 50:1741-1748; doi:10.2337/diabetes.50.8.1741
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- Mark Peakman,
- Timothy I. Tree,
- Josef Endl,
- Peter van Endert,
- Mark A. Atkinson,
- and Bart O. Roep
Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes: Report of Phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell Assays in Type 1 Diabetes
Diabetes August 2001 50:1749-1754; doi:10.2337/diabetes.50.8.1749

Islet Studies

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- T. Rosenbaum,
- M.C. Sánchez-Soto,
- and M. Hiriart
Nerve Growth Factor Increases Insulin Secretion and Barium Current in Pancreatic β-Cells
Diabetes August 2001 50:1755-1762; doi:10.2337/diabetes.50.8.1755
Select this article
- Maren Skau,
- Bente Pakkenberg,
- Karsten Buschard,
- and Troels Bock
Linear Correlation Between the Total Islet Mass and the Volume-Weighted Mean Islet Volume
Diabetes August 2001 50:1763-1770; doi:10.2337/diabetes.50.8.1763
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- Miriam Cnop,
- Jean Claude Hannaert,
- Anne Hoorens,
- Décio L. Eizirik,
- and Daniel G. Pipeleers
Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation
Diabetes August 2001 50:1771-1777; doi:10.2337/diabetes.50.8.1771
Select this article
- Claus B. Juhl,
- Niels Pørksen,
- Steven M. Pincus,
- Åge P. Hansen,
- Johannes D. Veldhuis,
- and Ole Schmitz
Acute and Short-Term Administration of a Sulfonylurea (Gliclazide) Increases Pulsatile Insulin Secretion in Type 2 Diabetes
Diabetes August 2001 50:1778-1784; doi:10.2337/diabetes.50.8.1778
Select this article
- Johanna Westerlund and
- Peter Bergsten
Glucose Metabolism and Pulsatile Insulin Release From Isolated Islets
Diabetes August 2001 50:1785-1790; doi:10.2337/diabetes.50.8.1785
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- Robert H. Skelly,
- Barton Wicksteed,
- Peter A. Antinozzi,
- and Christopher J. Rhodes
Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism
Diabetes August 2001 50:1791-1798; doi:10.2337/diabetes.50.8.1791
Select this article
- Gil Leibowitz,
- Sarah Ferber,
- Åsa Apelqvist,
- Helena Edlund,
- David J. Gross,
- Erol Cerasi,
- Danielle Melloul,
- and Nurit Kaiser
IPF1/PDX1 Deficiency and β-Cell Dysfunction in Psammomys obesus, an Animal With Type 2 Diabetes
Diabetes August 2001 50:1799-1806; doi:10.2337/diabetes.50.8.1799

Complications

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- Ashwani Malhotra,
- Barinder P.S. Kang,
- Simon Cheung,
- David Opawumi,
- and Leonard G. Meggs
Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I
Diabetes August 2001 50:1918-1926; doi:10.2337/diabetes.50.8.1918
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- Lawrence J. Coppey,
- Jill S. Gellett,
- Eric P. Davidson,
- Joyce A. Dunlap,
- Donald D. Lund,
- and Mark A. Yorek
Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve
Diabetes August 2001 50:1927-1937; doi:10.2337/diabetes.50.8.1927
Select this article
- Renu A. Kowluru,
- Jie Tang,
- and Timothy S. Kern
Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy
Diabetes August 2001 50:1938-1942; doi:10.2337/diabetes.50.8.1938

Genetics

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- Toshihide Shike,
- Sachiko Hirose,
- Michimasa Kobayashi,
- Kazuhiko Funabiki,
- Toshikazu Shirai,
- and Yasuhiko Tomino
Susceptibility and Negative Epistatic Loci Contributing to Type 2 Diabetes and Related Phenotypes in a KK/Ta Mouse Model
Diabetes August 2001 50:1943-1948; doi:10.2337/diabetes.50.8.1943

Brief Genetics Report

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- Hua Wang,
- Johanna Rissanen,
- Raija Miettinen,
- Päivi Kärkkäinen,
- Päivi Kekäläinen,
- Johanna Kuusisto,
- Leena Mykkänen,
- Pauli Karhapää,
- and Markku Laakso
New Amino Acid Substitutions in the IRS-2 Gene in Finnish and Chinese Subjects With Late-Onset Type 2 Diabetes
Diabetes August 2001 50:1949-1951; doi:10.2337/diabetes.50.8.1949
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- Lucia Frittitta,
- Tonino Ercolino,
- Maura Bozzali,
- Alessandra Argiolas,
- Salvo Graci,
- Maria G. Santagati,
- Daniela Spampinato,
- Rosa Di Paola,
- Carmela Cisternino,
- Vittorio Tassi,
- Riccardo Vigneri,
- Antonio Pizzuti,
- and Vincenzo Trischitta
A Cluster of Three Single Nucleotide Polymorphisms in the 3′-Untranslated Region of Human Glycoprotein PC-1 Gene Stabilizes PC-1 mRNA and Is Associated With Increased PC-1 Protein Content and Insulin Resistance–Related Abnormalities
Diabetes August 2001 50:1952-1955; doi:10.2337/diabetes.50.8.1952

Diabetes

Rapid Publication

Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets

Insulin Production by Human Embryonic Stem Cells

Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane

Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

Metabolism and Signal Transduction

Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor

T-Cell Epitope Analysis on the Autoantigen Phogrin (IA-2β) in the Nonobese Diabetic Mouse

Expression of GAD65 and Islet Cell Antibody (ICA512) Autoantibodies Among Cytoplasmic ICA+ Relatives Is Associated With Eligibility for the Diabetes Prevention Trial−Type 1

Cytokine Induction of Fas Gene Expression in Insulin-Producing Cells Requires the Transcription Factors NF-κB and C/EBP

Islet Studies

Nerve Growth Factor Increases Insulin Secretion and Barium Current in Pancreatic β-Cells

Linear Correlation Between the Total Islet Mass and the Volume-Weighted Mean Islet Volume

Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

Acute and Short-Term Administration of a Sulfonylurea (Gliclazide) Increases Pulsatile Insulin Secretion in Type 2 Diabetes

Glucose Metabolism and Pulsatile Insulin Release From Isolated Islets

Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism

IPF1/PDX1 Deficiency and β-Cell Dysfunction in Psammomys obesus, an Animal With Type 2 Diabetes

Pathophysiology

Effect of Physiological Hyperinsulinemia on Gluconeogenesis in Nondiabetic Subjects and in Type 2 Diabetic Patients

Treatment of Type 2 Diabetes by Adenoviral-Mediated Overexpression of the Glucokinase Regulatory Protein

Alteration in Phosphorylation of P20 Is Associated With Insulin Resistance

Low Acute Insulin Secretory Responses in Adult Offspring of People With Early Onset Type 2 Diabetes

Insulin Secretion and Glucose Kinetics During Exercise With and Without Pharmacological α1- and α2-Receptor Blockade

Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome

Glucose Regulates the Transcription of Human Genes Relevant to HDL Metabolism: Responsive Elements for Peroxisome Proliferator–Activated Receptor Are Involved in the Regulation of Phospholipid Transfer Protein

Menopause in Type 1 Diabetic Women: Is it Premature?

Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance

Small Increases in Insulin Inhibit Hepatic Glucose Production Solely Caused by an Effect on Glycogen Metabolism

Bezafibrate Reduces mRNA Levels of Adipocyte Markers and Increases Fatty Acid Oxidation in Primary Culture of Adipocytes

Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes

Defective Insulin-Induced GLUT4 Translocation in Skeletal Muscle of High Fat–Fed Rats Is Associated With Alterations in Both Akt/Protein Kinase B and Atypical Protein Kinase C (ζ/λ) Activities

Blood-to-Brain Glucose Transport, Cerebral Glucose Metabolism, and Cerebral Blood Flow Are Not Increased After Hypoglycemia

Complications

Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve

Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy

Genetics

Susceptibility and Negative Epistatic Loci Contributing to Type 2 Diabetes and Related Phenotypes in a KK/Ta Mouse Model

Brief Genetics Report

New Amino Acid Substitutions in the IRS-2 Gene in Finnish and Chinese Subjects With Late-Onset Type 2 Diabetes

A Cluster of Three Single Nucleotide Polymorphisms in the 3′-Untranslated Region of Human Glycoprotein PC-1 Gene Stabilizes PC-1 mRNA and Is Associated With Increased PC-1 Protein Content and Insulin Resistance–Related Abnormalities

This Issue

Current Issue

Insulin Secretion and Glucose Kinetics During Exercise With and Without Pharmacological α₁- and α₂-Receptor Blockade