Table of Contents

• Karin Filipsson,
• Martina Kvist-Reimer,
• and Bo Ahrén

The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function

• Raphaël Roduit,
• Pellegrino Masiello,
• Shu Pei Wang,
• Hong Li,
• Grant A. Mitchell,
• and Marc Prentki

A Role for Hormone-Sensitive Lipase in Glucose-Stimulated Insulin Secretion: A Study in Hormone-Sensitive Lipase-Deficient Mice

• Karin Jury,
• Petra Söhnlein,
• Monique Vogel,
• and Wiltrud Richter

Isolation and Functional Characterization of Recombinant GAD65 Autoantibodies Derived by IgG Repertoire Cloning From Patients With Type 1 Diabetes

• Antonello Pileggi,
• R. Damaris Molano,
• Thierry Berney,
• Pierre Cattan,
• Caterina Vizzardelli,
• Robert Oliver,
• Christopher Fraker,
• Camillo Ricordi,
• Ricardo L. Pastori,
• Fritz H. Bach,
• and Luca Inverardi

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

• David V. Serreze,
• Ellis A. Johnson,
• Harold D. Chapman,
• Robert T. Graser,
• Michele P. Marron,
• Teresa P. DiLorenzo,
• Pablo Silveira,
• Yoshitaka Yoshimura,
• Stanley G. Nathenson,
• and Sebastian Joyce

Autoreactive Diabetogenic T-Cells in NOD Mice Can Efficiently Expand From a Greatly Reduced Precursor Pool

• Lise L. Kjems,
• Barbara M. Kirby,
• Elizabeth M. Welsh,
• Johannes D. Veldhuis,
• Marty Straume,
• Susan S. McIntyre,
• Dongchang Yang,
• Pierre Lefèbvre,
• and Peter C. Butler

Decrease in β-Cell Mass Leads to Impaired Pulsatile Insulin Secretion, Reduced Postprandial Hepatic Insulin Clearance, and Relative Hyperglucagonemia in the Minipig

• Seamus K. Sreenan,
• Yun-Ping Zhou,
• Kenichi Otani,
• Polly A. Hansen,
• Kevin P.M. Currie,
• Chien-Yuan Pan,
• Jean-Pyo Lee,
• Diane M. Ostrega,
• William Pugh,
• Yukio Horikawa,
• Nancy J. Cox,
• Craig L. Hanis,
• Charles F. Burant,
• Aaron P. Fox,
• Graeme I. Bell,
• and Kenneth S. Polonsky

Calpains Play a Role in Insulin Secretion and Action

• Latif Rachdi,
• Lynda El Ghazi,
• Florence Bernex,
• Jean-Jacques Panthier,
• Paul Czernichow,
• and Raphael Scharfmann

Expression of the Receptor Tyrosine Kinase KIT in Mature β-Cells and in the Pancreas in Development

• Hiroshi Kajio,
• Scott Olszewski,
• Philip J. Rosner,
• Matthew J. Donelan,
• Kieran F. Geoghegan,
• and Christopher J. Rhodes

A Low-Affinity Ca²⁺-Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis

• Hainan Chen,
• Edward C. Carlson,
• Lori Pellet,
• Jon T. Moritz,
• and Paul N. Epstein

Overexpression of Metallothionein in Pancreatic β-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes

• Coralie Bingham,
• Sian Ellard,
• Anthony J. Nicholls,
• Charles A. Pennock,
• John Allen,
• Alan J. James,
• Simon C. Satchell,
• Maurice B. Salzmann,
• and Andrew T. Hattersley

The Generalized Aminoaciduria Seen in Patients With Hepatocyte Nuclear Factor-1α Mutations Is a Feature of All Patients With Diabetes and Is Associated With Glucosuria

• Fei Song,
• Malathi Srinivasan,
• Ravikumar Aalinkeel,
• and Mulchand S. Patel

Use of a cDNA Array for the Identification of Genes Induced in Islets of Suckling Rats by a High-Carbohydrate Nutritional Intervention

• Luc Marti,
• Anna Abella,
• Christian Carpéné,
• Manuel Palacín,
• Xavier Testar,
• and Antonio Zorzano

Combined Treatment With Benzylamine and Low Dosages of Vanadate Enhances Glucose Tolerance and Reduces Hyperglycemia in Streptozotocin-Induced Diabetic Rats

• Katherine V. Williams,
• Julie C. Price,
• and David E. Kelley

Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance: A Dose-Response Assessment Using Positron Emission Tomography

• Anne Bouloumié,
• Coralie Sengenès,
• Ghyslaine Portolan,
• Jean Galitzky,
• and Max Lafontan

Adipocyte Produces Matrix Metalloproteinases 2 and 9: Involvement in Adipose Differentiation

• Eugenio Cersosimo,
• Peter Garlick,
• and John Ferretti

Abnormal Glucose Handling by the Kidney in Response to Hypoglycemia in Type 1 Diabetes

• Norikazu Maeda,
• Masahiko Takahashi,
• Tohru Funahashi,
• Shinji Kihara,
• Hitoshi Nishizawa,
• Ken Kishida,
• Hiroyuki Nagaretani,
• Morihiro Matsuda,
• Ryutaro Komuro,
• Noriyuki Ouchi,
• Hiroshi Kuriyama,
• Kikuko Hotta,
• Tadashi Nakamura,
• Iichiro Shimomura,
• and Yuji Matsuzawa

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

• Akos Nagy,
• Hiroyuki Nagashima,
• Seunghee Cha,
• Gregory E. Oxford,
• Tivadar Zelles,
• Ammon B. Peck,
• and Michael G. Humphreys-Beher

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

• Daniela Dyntar,
• Monika Eppenberger-Eberhardt,
• Kathrin Maedler,
• Martin Pruschy,
• Hans M. Eppenberger,
• Giatgen A. Spinas,
• and Marc Y. Donath

Glucose and Palmitic Acid Induce Degeneration of Myofibrils and Modulate Apoptosis in Rat Adult Cardiomyocytes

• Patricia A. Craven,
• Mona F. Melhem,
• Stephen L. Phillips,
• and Frederick R. DeRubertis

Overexpression of Cu²⁺/Zn²⁺ Superoxide Dismutase Protects Against Early Diabetic Glomerular Injury in Transgenic Mice

• Urban Olsson,
• Ann-Charlotte Egnell,
• Mariam Rodríguez Lee,
• Gunnel Östergren Lundén,
• Malin Lorentzon,
• Markku Salmivirta,
• Göran Bondjers,
• and Germán Camejo

Changes in Matrix Proteoglycans Induced by Insulin and Fatty Acids in Hepatic Cells May Contribute to Dyslipidemia of Insulin Resistance

• Thomas Netticadan,
• Rana M. Temsah,
• Ardeep Kent,
• Vijayan Elimban,
• and Naranjan S. Dhalla

Depressed Levels of Ca²⁺-Cycling Proteins May Underlie Sarcoplasmic Reticulum Dysfunction in the Diabetic Heart

• Benjamin S. Szwergold,
• Scott Howell,
• and Paul J. Beisswenger

Human Fructosamine-3-Kinase: Purification, Sequencing, Substrate Specificity, and Evidence of Activity In Vivo

• Declan J. James,
• Fiona Cairns,
• Ian P. Salt,
• Gregory J. Murphy,
• Anna F. Dominiczak,
• John M.C. Connell,
• and Gwyn W. Gould

Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and Flotillin

• Emanuele Miraglia del Giudice,
• Nicola Santoro,
• Grazia Cirillo,
• Luigi D’Urso,
• Rosario Di Toro,
• and Laura Perrone

Mutational Screening of the CART Gene in Obese Children: Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Family

• Michael Stumvoll,
• Andreas Fritsche,
• Alexander Madaus,
• Norbert Stefan,
• Melanie Weisser,
• Fausto Machicao,
• and Hans Häring

Functional Significance of the UCSNP-43 Polymorphism in the CAPN10 Gene for Proinsulin Processing and Insulin Secretion in Nondiabetic Germans

• Samira Ait El Mkadem,
• Corinne Lautier,
• Françoise Macari,
• Nicolas Molinari,
• Patrick Lefèbvre,
• Eric Renard,
• Jean Christophe Gris,
• Gérard Cros,
• Jean Pierre Daurès,
• Jacques Bringer,
• Morris F. White,
• and Florin Grigorescu

Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome

• Douglas Osei-Hyiaman,
• Lifang Hou,
• Ren Zhiyin,
• Zhang Zhiming,
• Haiquin Yu,
• Abena Agyeiwaa Amankwah,
• and Shoji Harada

Association of a Novel Point Mutation (C159G) of the CTLA4 Gene With Type 1 Diabetes in West Africans but not in Chinese

• Barbara J. Nicklas,
• Elisabeth F.C. van Rossum,
• Dora M. Berman,
• Alice S. Ryan,
• Karen E. Dennis,
• and Alan R. Shuldiner

Genetic Variation in the Peroxisome Proliferator–Activated Receptor-γ2 Gene (Pro12Ala) Affects Metabolic Responses to Weight Loss and Subsequent Weight Regain

Erratum