• E Cerasi,
• C Boitard,
• S Efendic,
• E Ferrannini,
• J C Henquin,
• and D F Steiner

The islet in type 2 diabetes: back to center stage.

• H Edlund

Developmental biology of the pancreas.

• Y Q Zhang,
• H Mashima,
• and I Kojima

Changes in the expression of transcription factors in pancreatic AR42J cells during differentiation into insulin-producing cells.

• T Moede,
• B Leibiger,
• P O Berggren,
• and I B Leibiger

Online monitoring of stimulus-induced gene expression in pancreatic beta-cells.

• S Bonner-Weir

beta-cell turnover: its assessment and implications.

• J H Nielsen,
• E D Galsgaard,
• A Møldrup,
• B N Friedrichsen,
• N Billestrup,
• J A Hansen,
• Y C Lee,
• and C Carlsson

Regulation of beta-cell mass by hormones and growth factors.

• C Bernard-Kargar and
• A Ktorza

Endocrine pancreas plasticity under physiological and pathological conditions.

• N Baeza,
• A Hart,
• U Ahlgren,
• and H Edlund

Insulin promoter factor-1 controls several aspects of beta-cell identity.

• S Marshak,
• E Ben-Shushan,
• M Shoshkes,
• L Havin,
• E Cerasi,
• and D Melloul

Regulatory elements involved in human pdx-1 gene expression.

• H Mashima,
• Y Q Zhang,
• T Tajima,
• J Takeda,
• and I Kojima

Na-Pi cotransporter expressed during the differentiation of pancreatic AR42J cells.

• E D Galsgaard,
• B N Friedrichsen,
• J H Nielsen,
• and A Møldrup

Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells.

• A Sharma,
• M Taneja,
• P Rietz,
• J Weitekamp,
• and S Bonner-Weir

Novel pancreatic precursor cell lines for studying beta-cell differentiation.

• J Chandra,
• B Zhivotovsky,
• S Zaitsev,
• L Juntti-Berggren,
• P O Berggren,
• and S Orrenius

Role of apoptosis in pancreatic beta-cell death in diabetes.

• T Miki,
• T Iwanaga,
• K Nagashima,
• Y Ihara,
• and S Seino

Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas.

• D Pipeleers,
• A Hoorens,
• M Marichal-Pipeleers,
• M Van de Casteele,
• L Bouwens,
• and Z Ling

Role of pancreatic beta-cells in the process of beta-cell death.

• T Mandrup-Poulsen

beta-cell apoptosis: stimuli and signaling.

• D L Eizirik and
• M I Darville

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.

• S V Zaitsev,
• I B Appelskog,
• I L Kapelioukh,
• S N Yang,
• M Köhler,
• S Efendic,
• and P O Berggren

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis.

• J Chandra,
• S N Yang,
• M Köhler,
• S Zaitsev,
• L Juntti-Berggren,
• P O Berggren,
• B Zhivotovsky,
• and S Orrenius

Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells.

Cytokine-mediated apoptosis in rat beta-cells is preceded by downregulation of Bcl-2 and Bax-omega expression

• M I Darville,
• D Liu,
• M C Chen,
• and D L Eizirik

Molecular regulation of Fas expression in beta-cells.

• F Miralles and
• B Portha

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes.

• B Portha,
• M H Giroix,
• P Serradas,
• M N Gangnerau,
• J Movassat,
• F Rajas,
• D Bailbe,
• C Plachot,
• G Mithieux,
• and J C Marie

beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony.

• T M Frayling,
• J C Evans,
• M P Bulman,
• E Pearson,
• L Allen,
• K Owen,
• C Bingham,
• M Hannemann,
• M Shepherd,
• S Ellard,
• and A T Hattersley

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

• E R Pearson,
• G Velho,
• P Clark,
• A Stride,
• M Shepherd,
• T M Frayling,
• M P Bulman,
• S Ellard,
• P Froguel,
• and A T Hattersley

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

• Z C Ling,
• C Hong-Lie,
• C G Ostenson,
• S Efendic,
• and A Khan

Hyperglycemia contributes to impaired insulin response in GK rat islets.

• G Leibowitz,
• M Yuli,
• M Y Donath,
• R Nesher,
• D Melloul,
• E Cerasi,
• D J Gross,
• and N Kaiser

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

• R H Unger and
• Y T Zhou

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

• V Grill and
• A Björklund

Overstimulation and beta-cell function.

• C Bernard-Kargar,
• N Kassis,
• M F Berthault,
• W Pralong,
• and A Ktorza

Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.

• S Marshak,
• E Benshushan,
• M Shoshkes,
• G Leibovitz,
• N Kaiser,
• D Gross,
• F Bertuzzi,
• E Cerasi,
• and D Melloul

beta-cell-specific expression of insulin and PDX-1 genes.

• Y Kashima,
• T Miki,
• K Minami,
• and S Seino

Establishment of a tet-on gene expression system in glucose-responsive and -unresponsive MIN6 cells.

Identification of genes involved in glucose-stimulated insulin secretion

• G C Webb,
• M S Akbar,
• C Zhao,
• and D F Steiner

Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes.

• J C Jonas,
• R Laybutt,
• G M Steil,
• N Trivedi,
• G C Weir,
• and J C Henquin

Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration.

• G Leibowitz,
• D Melloul,
• M Yuli,
• D J Gross,
• A Apelqvist,
• H Edlund,
• E Cerasi,
• and N Kaiser

Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.

• D J Burks and
• M F White

IRS proteins and beta-cell function.

• M Jackerott,
• A Baudry,
• B Lamothe,
• D Bucchini,
• J Jami,
• and R L Joshi

Endocrine pancreas in insulin receptor-deficient mouse pups.

• L Leroux,
• P Desbois,
• L Lamotte,
• B Duvillié,
• N Cordonnier,
• M Jackerott,
• J Jami,
• D Bucchini,
• and R L Joshi

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

• G C Weir,
• D R Laybutt,
• H Kaneto,
• S Bonner-Weir,
• and A Sharma

Beta-cell adaptation and decompensation during the progression of diabetes.

• D Porte, Jr and
• S E Kahn

beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.

• A Mari,
• S Camastra,
• E Toschi,
• A Giancaterini,
• A Gastaldelli,
• G Mingrone,
• and E Ferrannini

A model for glucose control of insulin secretion during 24 h of free living.

• A Clark,
• L C Jones,
• E de Koning,
• B C Hansen,
• and D R Matthews

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

• C Sempoux,
• Y Guiot,
• D Dubois,
• P Moulin,
• and J Rahier

Human type 2 diabetes: morphological evidence for abnormal beta-cell function.

• E Toschi,
• S Camastra,
• A Mari,
• A Gastaldelli,
• S Baldi,
• A Masoni,
• and E Ferrannini

A model for assessing insulin secretion and its control under free-living conditions.

• R Laybutt,
• W Hasenkamp,
• A Groff,
• S Grey,
• J C Jonas,
• H Kaneto,
• A Sharma,
• S Bonner-Weir,
• and G Weir

beta-cell adaptation to hyperglycemia.

• C Sempoux,
• Y Guiot,
• and J Rahier

The focal form of persistent hyperinsulinemic hypoglycemia of infancy.

• R L Hull,
• C B Verchere,
• S Andrikopoulos,
• F Wang,
• J Vidal,
• and S E Kahn

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.

• L C Jones and
• A Clark

beta-cell neogenesis in type 2 diabetes.

• Y Guiot,
• C Sempoux,
• P Moulin,
• and J Rahier

No decrease of the beta-cell mass in type 2 diabetic patients.

• S Efrat

Prospects for treatment of type 2 diabetes by expansion of the beta-cell mass.