Table of Contents

Rapid Publication

Select this article
- Søren M. Echwald,
- Helle Bach,
- Henrik Vestergaard,
- Bjørn Richelsen,
- Kurt Kristensen,
- Thomas Drivsholm,
- Knut Borch-Johnsen,
- Torben Hansen,
- and Oluf Pedersen
A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro
Diabetes January 2002 51:1-6; published ahead of print December 11, 2001, doi:10.2337/diabetes.51.1.1

Banting Lecture 2001

Select this article
- J. Denis McGarry
Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes
Diabetes January 2002 51:7-18; doi:10.2337/diabetes.51.1.7

Metabolism and Signal Transduction

Select this article
- Jianhua Shao,
- Hiroshi Yamashita,
- Liping Qiao,
- Boris Draznin,
- and Jacob E. Friedman
Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus
Diabetes January 2002 51:19-29; doi:10.2337/diabetes.51.1.19
Select this article
- Theodore P. Ciaraldi,
- Alice P.S. Kong,
- Neelima V. Chu,
- Dennis D. Kim,
- Sunita Baxi,
- Mattias Loviscach,
- Ray Plodkowski,
- Richard Reitz,
- Michael Caulfield,
- Sunder Mudaliar,
- and Robert R. Henry
Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects
Diabetes January 2002 51:30-36; doi:10.2337/diabetes.51.1.30
Select this article
- Michael Stumvoll,
- Otto Tschritter,
- Andreas Fritsche,
- Harald Staiger,
- Walter Renn,
- Melanie Weisser,
- Fausto Machicao,
- and Hans Häring
Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes
Diabetes January 2002 51:37-41; doi:10.2337/diabetes.51.1.37
Select this article
- M.A. Vincent,
- D. Dawson,
- A.D.H. Clark,
- J.R. Lindner,
- S. Rattigan,
- M.G. Clark,
- and E.J. Barrett
Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow
Diabetes January 2002 51:42-48; doi:10.2337/diabetes.51.1.42
Select this article
- Martin G. Bischof,
- Elisabeth Bernroider,
- Martin Krssak,
- Michael Krebs,
- Harald Stingl,
- Peter Nowotny,
- Chunlin Yu,
- Gerald I. Shulman,
- Werner Waldhäusl,
- and Michael Roden
Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia
Diabetes January 2002 51:49-54; doi:10.2337/diabetes.51.1.49

Immunology and Transplantation

Select this article
- Lorenzo Piemonti,
- Biagio Eugenio Leone,
- Rita Nano,
- Alessandra Saccani,
- Paolo Monti,
- Paola Maffi,
- Giancarlo Bianchi,
- Antonio Sica,
- Giuseppe Peri,
- Raffaella Melzi,
- Luca Aldrighetti,
- Antonio Secchi,
- Valerio Di Carlo,
- Paola Allavena,
- and Federico Bertuzzi
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
Diabetes January 2002 51:55-65; doi:10.2337/diabetes.51.1.55
Select this article
- Montserrat Biarnés,
- Marta Montolio,
- Victor Nacher,
- Mercè Raurell,
- Joan Soler,
- and Eduard Montanya
β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia
Diabetes January 2002 51:66-72; doi:10.2337/diabetes.51.1.66
Select this article
- Fraser W. Scott,
- Paul Rowsell,
- Gen-Sheng Wang,
- Karolina Burghardt,
- Hubert Kolb,
- and Stefanie Flohé
Oral Exposure to Diabetes-Promoting Food or Immunomodulators in Neonates Alters Gut Cytokines and Diabetes
Diabetes January 2002 51:73-78; doi:10.2337/diabetes.51.1.73
Select this article
- Henrik Krook,
- Anette Hagberg,
- Zhenshun Song,
- Ulf Landegren,
- Lars Wennberg,
- and Olle Korsgren
A Distinct Th1 Immune Response Precedes the Described Th2 Response in Islet Xenograft Rejection
Diabetes January 2002 51:79-86; doi:10.2337/diabetes.51.1.79

Islet Study

Select this article
- Kazuhiro Eto,
- Tokuyuki Yamashita,
- Yoshiharu Tsubamoto,
- Yasuo Terauchi,
- Kenzo Hirose,
- Naoto Kubota,
- Shigeo Yamashita,
- Junko Taka,
- Shinobu Satoh,
- Hisahiko Sekihara,
- Kazuyuki Tobe,
- Masamitsu Iino,
- Mitsuhiko Noda,
- Satoshi Kimura,
- and Takashi Kadowaki
Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca²⁺] Elevation Signals
Diabetes January 2002 51:87-97; doi:10.2337/diabetes.51.1.87
Select this article
- Shanta J. Persaud,
- Helen M. Roderigo-Milne,
- Paul E. Squires,
- David Sugden,
- Caroline P.D. Wheeler-Jones,
- Phil J. Marsh,
- Véronique D. Belin,
- Melanie J. Luther,
- and Peter M. Jones
A Key Role for β-Cell Cytosolic Phospholipase A₂ in the Maintenance of Insulin Stores But Not in the Initiation of Insulin Secretion
Diabetes January 2002 51:98-104; doi:10.2337/diabetes.51.1.98
Select this article
- Subhadra C. Gunawardana and
- Geoffrey W.G. Sharp
Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets
Diabetes January 2002 51:105-113; doi:10.2337/diabetes.51.1.105
Select this article
- Kazuya Yamagata,
- Takao Nammo,
- Makoto Moriwaki,
- Arisa Ihara,
- Katsumi Iizuka,
- Qin Yang,
- Tomomi Satoh,
- Ming Li,
- Rikako Uenaka,
- Kohei Okita,
- Hiromi Iwahashi,
- Qian Zhu,
- Yang Cao,
- Akihisa Imagawa,
- Yoshihiro Tochino,
- Toshiaki Hanafusa,
- Jun-ichiro Miyagawa,
- and Yuji Matsuzawa
Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes
Diabetes January 2002 51:114-123; doi:10.2337/diabetes.51.1.114
Select this article
- Yukari Date,
- Masamitsu Nakazato,
- Suzuko Hashiguchi,
- Katsuya Dezaki,
- Muhtashan S. Mondal,
- Hiroshi Hosoda,
- Masayasu Kojima,
- Kenji Kangawa,
- Terukatsu Arima,
- Hisayuki Matsuo,
- Toshihiko Yada,
- and Shigeru Matsukura
Ghrelin Is Present in Pancreatic α-Cells of Humans and Rats and Stimulates Insulin Secretion
Diabetes January 2002 51:124-129; doi:10.2337/diabetes.51.1.124

Pathophysiology

Select this article
- Hengjiang Dong,
- Jennifer Altomonte,
- Nuria Morral,
- Marcia Meseck,
- Swan N. Thung,
- and Savio L.C. Woo
Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats
Diabetes January 2002 51:130-138; doi:10.2337/diabetes.51.1.130
Select this article
- Gilles Mithieux,
- Ludovic Guignot,
- Jean-Claude Bordet,
- and Nicolas Wiernsperger
Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet
Diabetes January 2002 51:139-143; doi:10.2337/diabetes.51.1.139
Select this article
- Aldo V. Greco,
- Gertrude Mingrone,
- Annalisa Giancaterini,
- Melania Manco,
- Manrico Morroni,
- Saverio Cinti,
- Marnie Granzotto,
- Roberto Vettor,
- Stefania Camastra,
- and Ele Ferrannini
Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion
Diabetes January 2002 51:144-151; doi:10.2337/diabetes.51.1.144
Select this article
- Katherine Baran,
- Elaine Preston,
- Donna Wilks,
- Gregory J. Cooney,
- Edward W. Kraegen,
- and Amanda Sainsbury
Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways
Diabetes January 2002 51:152-158; doi:10.2337/diabetes.51.1.152

Complication

Select this article
- Yasuo Ido,
- David Carling,
- and Neil Ruderman
Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells: Inhibition by the AMP-Activated Protein Kinase Activation
Diabetes January 2002 51:159-167; doi:10.2337/diabetes.51.1.159
Select this article
- Carmine Vecchione,
- Angelo Maffei,
- Salvatore Colella,
- Alessandra Aretini,
- Roberta Poulet,
- Giacomo Frati,
- Maria Teresa Gentile,
- Luigi Fratta,
- Valentina Trimarco,
- Bruno Trimarco,
- and Giuseppe Lembo
Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway
Diabetes January 2002 51:168-173; doi:10.2337/diabetes.51.1.168
Select this article
- Qiangrong Liang,
- Edward C. Carlson,
- Rajakumar V. Donthi,
- Patrica M. Kralik,
- Xia Shen,
- and Paul N. Epstein
Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy
Diabetes January 2002 51:174-181; doi:10.2337/diabetes.51.1.174
Select this article
- Ivan Tack,
- Sharon J. Elliot,
- Mylene Potier,
- Ana Rivera,
- Gary E. Striker,
- and Liliane J. Striker
Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice
Diabetes January 2002 51:182-188; doi:10.2337/diabetes.51.1.182
Select this article
- Kristina F. Standeven,
- Robert A.S. Ariëns,
- Paul Whitaker,
- Alison E. Ashcroft,
- John W. Weisel,
- and Peter J. Grant
The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation
Diabetes January 2002 51:189-197; doi:10.2337/diabetes.51.1.189
Select this article
- Ming-Hui Zou,
- Chaomei Shi,
- and Richard A. Cohen
High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H₂ Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells
Diabetes January 2002 51:198-203; doi:10.2337/diabetes.51.1.198

Epidemiology

Select this article
- Sathanur R. Srinivasan,
- Leann Myers,
- and Gerald S. Berenson
Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood: The Bogalusa Heart Study
Diabetes January 2002 51:204-209; doi:10.2337/diabetes.51.1.204
Select this article
- Kathleen M. Gillespie,
- Edwin A.M. Gale,
- and Polly J. Bingley
High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes
Diabetes January 2002 51:210-214; doi:10.2337/diabetes.51.1.210
Select this article
- Marsha Grattan,
- Qing-Sheng Mi,
- Craig Meagher,
- and Terry L. Delovitch
Congenic Mapping of the Diabetogenic Locus Idd4 to a 5.2-cM Region of Chromosome 11 in NOD Mice: Identification of Two Potential Candidate Subloci
Diabetes January 2002 51:215-223; doi:10.2337/diabetes.51.1.215
Select this article
- Tetsuyuki Yasuda,
- Yoshitaka Kajimoto,
- Yoshio Fujitani,
- Hirotaka Watada,
- Shuji Yamamoto,
- Takao Watarai,
- Yutaka Umayahara,
- Munehide Matsuhisa,
- Shin-ichi Gorogawa,
- Yasuaki Kuwayama,
- Yasuo Tano,
- Yoshimitsu Yamasaki,
- and Masatsugu Hori
PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance
Diabetes January 2002 51:224-230; doi:10.2337/diabetes.51.1.224
Select this article
- Michael J. Garant,
- W.H. Linda Kao,
- Frederick Brancati,
- Josef Coresh,
- Tejal M. Rami,
- Craig L. Hanis,
- Eric Boerwinkle,
- and Alan R. Shuldiner
SNP43 of CAPN10 and the Risk of Type 2 Diabetes in African-Americans: The Atherosclerosis Risk in Communities Study
Diabetes January 2002 51:231-237; doi:10.2337/diabetes.51.1.231

Brief Genetics Report

Select this article
- Kunihiro Nakajima,
- Yasushi Tanaka,
- Takashi Nomiyama,
- Takeshi Ogihara,
- Lianshan Piao,
- Ken Sakai,
- Tomio Onuma,
- and Ryuzo Kawamori
Chemokine Receptor Genotype Is Associated With Diabetic Nephropathy in Japanese With Type 2 Diabetes
Diabetes January 2002 51:238-242; doi:10.2337/diabetes.51.1.238
Select this article
- Hiromasa Kobayashi,
- Yoshihiro Ogawa,
- Mitsuyo Shintani,
- Ken Ebihara,
- Makiko Shimodahira,
- Toshio Iwakura,
- Megumu Hino,
- Takashi Ishihara,
- Katsuji Ikekubo,
- Hiroyuki Kurahachi,
- and Kazuwa Nakao
A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity
Diabetes January 2002 51:243-246; doi:10.2337/diabetes.51.1.243
Select this article
- Stephen Lynn,
- Julie C. Evans,
- Christopher White,
- Timothy M. Frayling,
- Andrew T. Hattersley,
- Doug M. Turnbull,
- Yukio Horikawa,
- Nancy J. Cox,
- Graeme I. Bell,
- and Mark Walker
Variation in the Calpain-10 Gene Affects Blood Glucose Levels in the British Population
Diabetes January 2002 51:247-250; doi:10.2337/diabetes.51.1.247
Select this article
- Anna Solini,
- Michele Dalla Vestra,
- Alois Saller,
- Romano Nosadini,
- Gaetano Crepaldi,
- and Paola Fioretto
The Angiotensin-Converting Enzyme DD Genotype Is Associated With Glomerulopathy Lesions in Type 2 Diabetes
Diabetes January 2002 51:251-255; doi:10.2337/diabetes.51.1.251

Erratum

Select this article

Erratum
Diabetes January 2002 51:256; doi:10.2337/diabetes.51.1.256

Diabetes

Rapid Publication

A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro

Banting Lecture 2001

Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes

Metabolism and Signal Transduction

Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus

Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects

Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes

Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow

Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia

Immunology and Transplantation

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia

Oral Exposure to Diabetes-Promoting Food or Immunomodulators in Neonates Alters Gut Cytokines and Diabetes

A Distinct Th1 Immune Response Precedes the Described Th2 Response in Islet Xenograft Rejection

Islet Study

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals

A Key Role for β-Cell Cytosolic Phospholipase A2 in the Maintenance of Insulin Stores But Not in the Initiation of Insulin Secretion

Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Ghrelin Is Present in Pancreatic α-Cells of Humans and Rats and Stimulates Insulin Secretion

Pathophysiology

Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats

Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet

Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways

Complication

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells: Inhibition by the AMP-Activated Protein Kinase Activation

Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway

Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy

Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice

The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation

High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells

Epidemiology

Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood: The Bogalusa Heart Study

High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes

Congenic Mapping of the Diabetogenic Locus Idd4 to a 5.2-cM Region of Chromosome 11 in NOD Mice: Identification of Two Potential Candidate Subloci

PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance

SNP43 of CAPN10 and the Risk of Type 2 Diabetes in African-Americans: The Atherosclerosis Risk in Communities Study

Brief Genetics Report

Chemokine Receptor Genotype Is Associated With Diabetic Nephropathy in Japanese With Type 2 Diabetes

A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity

Variation in the Calpain-10 Gene Affects Blood Glucose Levels in the British Population

The Angiotensin-Converting Enzyme DD Genotype Is Associated With Glomerulopathy Lesions in Type 2 Diabetes

Erratum

Erratum

This Issue

Current Issue

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca²⁺] Elevation Signals

A Key Role for β-Cell Cytosolic Phospholipase A₂ in the Maintenance of Insulin Stores But Not in the Initiation of Insulin Secretion

High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H₂ Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells