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A: Schematic representation of intracellular disposition of fatty acids. Upper panel represents the disposition of fatty acids
in the normal state. An overload of fatty acids results in enhanced TG production (middle panel). Fatty acids will also be
converted into TG if their oxidative pathway is inhibited (lower panel). B: Influence of dietary fat content and etomoxir (Eto) on the rates of glucose infusion. C: Relationship between IMCL and glucose disposal in overnight-fasted rats before and during insulin infusion of 3 mU · kg−1 · min−1. Animals were fed for 4 weeks either with low-fat diet (4% fat) or lard diet (41% fat) with or without 0.01% R-etomoxir,
a CPT I inhibitor. Each value represents the mean ± SE for six to seven determinations (reproduced from ref. 27).