Banting Lecture 2001

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 4.
FIG. 4.

IMGU in muscle. In the absence of fatty acids, when insulin (I) binds to its receptor (IR), the sequence of events are as follows (dotted arrows). A: phosphorylation of the IRS-1 on a tyrosine residue, B: activation of phosphatidylinositol 3-kinase (PI3-K), and C: translocation of GLUT4 (G-4) to the membrane. In the presence of LCACoA, the insulin signaling cascade follows an abnormal pathway (solid arrows). D: generation of a diacylglycerol (DAG) pool; E: activation of PKCθ and phosphorylation of IRS-1 on a serine residue. This model is supported by work published by the laboratories of Shulman (18) and Kraegen (29).

This Article

  1. Diabetes vol. 51 no. 1 7-18