Table of Contents

Perspectives in Diabetes

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- Christopher B. Newgard
While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001
Diabetes November 2002 51:3141-3150

Metabolism and Signal Transduction

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- Dale S. Edgerton,
- Sylvain Cardin,
- Catherine Pan,
- Doss Neal,
- Ben Farmer,
- Margaret Converse,
- and Alan D. Cherrington.
Effects of Insulin Deficiency or Excess on Hepatic Gluconeogenic Flux During Glycogenolytic Inhibition in the Conscious Dog
Diabetes November 2002 51:3151-3162
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- Seng Khee Gan,
- Katherine Samaras,
- Campbell H. Thompson,
- Edward W. Kraegen,
- Andrew Carr,
- David A. Cooper,
- and Donald J. Chisholm
Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy
Diabetes November 2002 51:3163-3169
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- Stelios K. Tigas,
- Agneta L. Sunehag,
- and Morey W. Haymond
Impact of Duration of Infusion and Choice of Isotope Label on Isotope Recycling in Glucose Homeostasis
Diabetes November 2002 51:3170-3175
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- Hong Ruan,
- Philip D. G. Miles,
- Christine M. Ladd,
- Kenneth Ross,
- Todd R. Golub,
- Jerrold M. Olefsky,
- and Harvey F. Lodish
Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance
Diabetes November 2002 51:3176-3188

Obesity Studies

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- Hubert C. Chen,
- Scot J. Stone,
- Ping Zhou,
- Kimberly K. Buhman,
- and Robert V. Farese, Jr
Dissociation of Obesity and Impaired Glucose Disposal in Mice Overexpressing Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 in White Adipose Tissue
Diabetes November 2002 51:3189-3195
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- Deborah J. Clegg,
- Matt D. Wortman,
- Stephen C. Benoit,
- Charles C. McOsker,
- and Randy J. Seeley
Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion
Diabetes November 2002 51:3196-3201

Immunology and Transplantation

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- Leila Makhlouf,
- Koji Kishimoto,
- Rex N. Smith,
- Reza Abdi,
- Maria Koulmanda,
- Henry J. Winn,
- Hugh Auchincloss, Jr,
- and Mohamed H. Sayegh
The Role of Autoimmunity in Islet Allograft Destruction: Major Histocompatibility Complex Class II Matching Is Necessary for Autoimmune Destruction of Allogeneic Islet Transplants After T-Cell Costimulatory Blockade
Diabetes November 2002 51:3202-3210

Islet Studies

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- Jamie W. Joseph,
- Vasilij Koshkin,
- Chen-Yu Zhang,
- Jing Wang,
- Bradford B. Lowell,
- Catherine B. Chan,
- and Michael B. Wheeler
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
Diabetes November 2002 51:3211-3219
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- Naoki Kumagai,
- John C. LaMattina,
- Chisako Kamano,
- Parsia A. Vagefi,
- Rolf N. Barth,
- John J. O’Neil,
- Shin Yamamoto,
- Shannon G. Moran,
- Ryu Utsugi,
- David H. Sachs,
- and Kazuhiko Yamada
Vascularized Islet Cell Transplantation in Miniature Swine: Islet-Kidney Allografts Correct the Diabetic Hyperglycemia Induced by Total Pancreatectomy
Diabetes November 2002 51:3220-3228
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- Krishna Prasadan,
- Erica Daume,
- Barry Preuett,
- Troy Spilde,
- Amina Bhatia,
- Hiroyuki Kobayashi,
- Mark Hembree,
- Pradip Manna,
- and George K. Gittes
Glucagon Is Required for Early Insulin-Positive Differentiation in the Developing Mouse Pancreas
Diabetes November 2002 51:3229-3236
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- Wolfram Karges,
- Klaus Pechhold,
- Sascha Al Dahouk,
- Ines Riegger,
- Matthias Rief,
- Andrea Wissmann,
- Reinhold Schirmbeck,
- Christoph Barth,
- and Bernhard O. Boehm
Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice
Diabetes November 2002 51:3237-3244
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- Abdelilah Arredouani,
- Yves Guiot,
- Jean-Christophe Jonas,
- Lynne H. Liu,
- Myriam Nenquin,
- José A. Pertusa,
- Jacques Rahier,
- Jean-François Rolland,
- Gary E. Shull,
- Martine Stevens,
- Frank Wuytack,
- Jean-Claude Henquin,
- and Patrick Gilon
SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca²⁺ Pumps for Ca²⁺ Homeostasis in Pancreatic β-cells
Diabetes November 2002 51:3245-3253
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- John P. Mordes,
- Jean Leif,
- Stephen Novak,
- Cheryl DeScipio,
- Dale L. Greiner,
- and Elizabeth P. Blankenhorn
The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats
Diabetes November 2002 51:3254-3262

Pathophysiology

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- Carine Choleau,
- Petr Dokladal,
- Jean-Claude Klein,
- W. Kenneth Ward,
- George S. Wilson,
- and Gérard Reach
Prevention of Hypoglycemia Using Risk Assessment With a Continuous Glucose Monitoring System
Diabetes November 2002 51:3263-3273

Complications

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- Josephine M. Forbes,
- Mark E. Cooper,
- Vicki Thallas,
- Wendy C. Burns,
- Merlin C. Thomas,
- Gail C. Brammar,
- Fiona Lee,
- Sharon L. Grant,
- Louise M. Burrell,
- George Jerums,
- and Tanya M. Osicka
Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy
Diabetes November 2002 51:3274-3282
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- Jennifer L. Wilkinson-Berka,
- Darren J. Kelly,
- Suzanne M. Koerner,
- Kassie Jaworski,
- Belinda Davis,
- Vicki Thallas,
- and Mark E. Cooper
ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic (mREN-2)27 Rat
Diabetes November 2002 51:3283-3289
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- Denis Féliers,
- Meredith A. Frank,
- and Daniel J. Riley
Activation of Cyclin D1-Cdk4 and Cdk4-Directed Phosphorylation of RB Protein in Diabetic Mesangial Hypertrophy
Diabetes November 2002 51:3290-3299
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- Helen M. Colhoun,
- Marja-Riitta Taskinen,
- James D. Otvos,
- Paul van den Berg,
- John O’Connor,
- and Arie Van Tol
Relationship of Phospholipid Transfer Protein Activity to HDL and Apolipoprotein B-Containing Lipoproteins in Subjects With and Without Type 1 Diabetes
Diabetes November 2002 51:3300-3305
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- Mustafa Taskiran,
- Thomas Fritz-Hansen,
- Verner Rasmussen,
- Henrik B.W. Larsson,
- and Jannik Hilsted
Decreased Myocardial Perfusion Reserve in Diabetic Autonomic Neuropathy
Diabetes November 2002 51:3306-3310
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- Maria Felice Brizzi,
- Patrizia Dentelli,
- Roberto Gambino,
- Sara Cabodi,
- Maurizio Cassader,
- Ada Castelli,
- Paola Defilippi,
- Luigi Pegoraro,
- and Gianfranco Pagano
STAT5 Activation Induced by Diabetic LDL Depends on LDL Glycation and Occurs Via src Kinase Activity
Diabetes November 2002 51:3311-3317

Genetics

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- Kathryn G. Ewens,
- Lindsey N. Johnson,
- Beth Wapelhorst,
- Kristin O’Brien,
- Sarah Gutin,
- V. Anne Morrison,
- Craig Street,
- Simon G. Gregory,
- Richard S. Spielman,
- and Patrick Concannon
Linkage and Association With Type 1 Diabetes on Chromosome 1q42
Diabetes November 2002 51:3318-3325
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- Solange Nervi,
- Sandra Nicodeme,
- Corinne Gartioux,
- Catherine Atlan,
- Marc Lathrop,
- Denis Reviron,
- Philippe Naquet,
- Fumihiko Matsuda,
- Jean Imbert,
- and Bernard Vialettes
No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes
Diabetes November 2002 51:3326-3330

Brief Genetics Reports

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- Franz Krempler,
- Harald Esterbauer,
- Raimund Weitgasser,
- Christoph Ebenbichler,
- Josef R. Patsch,
- Karl Miller,
- Mingqiang Xie,
- Veronika Linnemayr,
- Hannes Oberkofler,
- and Wolfgang Patsch
A Functional Polymorphism in the Promoter of UCP2 Enhances Obesity Risk but Reduces Type 2 Diabetes Risk in Obese Middle-Aged Humans
Diabetes November 2002 51:3331-3335
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- Daniel B. Mirel,
- Ana Maria Valdes,
- Laura C. Lazzeroni,
- Rebecca L. Reynolds,
- Henry A. Erlich,
- and Janelle A. Noble
Association of IL4R Haplotypes With Type 1 Diabetes
Diabetes November 2002 51:3336-3341
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- Vidya S. Farook,
- Robert L. Hanson,
- Johanna K. Wolford,
- Clifton Bogardus,
- and Michal Prochazka
Molecular Analysis of KCNJ10 on 1q as a Candidate Gene for Type 2 Diabetes in Pima Indians
Diabetes November 2002 51:3342-3346
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- Adam Kretowski,
- Katarzyna Mironczuk,
- Anna Karpinska,
- Urszula Bojaryn,
- Maciej Kinalski,
- Zbigniew Puchalski,
- and Ida Kinalska
Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes
Diabetes November 2002 51:3347-3349

Erratum

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Erratum
Diabetes November 2002 51:3350

Diabetes

Perspectives in Diabetes

While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

Metabolism and Signal Transduction

Effects of Insulin Deficiency or Excess on Hepatic Gluconeogenic Flux During Glycogenolytic Inhibition in the Conscious Dog

Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

Impact of Duration of Infusion and Choice of Isotope Label on Isotope Recycling in Glucose Homeostasis

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance

Obesity Studies

Dissociation of Obesity and Impaired Glucose Disposal in Mice Overexpressing Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 in White Adipose Tissue

Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion

Immunology and Transplantation

The Role of Autoimmunity in Islet Allograft Destruction: Major Histocompatibility Complex Class II Matching Is Necessary for Autoimmune Destruction of Allogeneic Islet Transplants After T-Cell Costimulatory Blockade

Islet Studies

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Vascularized Islet Cell Transplantation in Miniature Swine: Islet-Kidney Allografts Correct the Diabetic Hyperglycemia Induced by Total Pancreatectomy

Glucagon Is Required for Early Insulin-Positive Differentiation in the Developing Mouse Pancreas

Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice

SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca2+ Pumps for Ca2+ Homeostasis in Pancreatic β-cells

The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats

Pathophysiology

Prevention of Hypoglycemia Using Risk Assessment With a Continuous Glucose Monitoring System

Complications

Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy

ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic (mREN-2)27 Rat

Activation of Cyclin D1-Cdk4 and Cdk4-Directed Phosphorylation of RB Protein in Diabetic Mesangial Hypertrophy

Relationship of Phospholipid Transfer Protein Activity to HDL and Apolipoprotein B-Containing Lipoproteins in Subjects With and Without Type 1 Diabetes

Decreased Myocardial Perfusion Reserve in Diabetic Autonomic Neuropathy

STAT5 Activation Induced by Diabetic LDL Depends on LDL Glycation and Occurs Via src Kinase Activity

Genetics

Linkage and Association With Type 1 Diabetes on Chromosome 1q42

No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes

Brief Genetics Reports

A Functional Polymorphism in the Promoter of UCP2 Enhances Obesity Risk but Reduces Type 2 Diabetes Risk in Obese Middle-Aged Humans

Association of IL4R Haplotypes With Type 1 Diabetes

Molecular Analysis of KCNJ10 on 1q as a Candidate Gene for Type 2 Diabetes in Pima Indians

Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes

Erratum

Erratum

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Current Issue

SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca²⁺ Pumps for Ca²⁺ Homeostasis in Pancreatic β-cells