Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence

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FIG. 3.FIG. 3.
FIG. 3.

A: Plasma glucagon response during hypoglycemic clamp of islet transplant recipients (•), type 1 diabetic subjects (▵), and nondiabetic control subjects (○). A significant rise in plasma glucagon was observed in the control group. No significant rise in mean plasma glucagon was observed in the islet transplant recipients or diabetic subjects. *P < 0.001 vs. basal, ANOVA. Inset: Islet transplant recipients showed a significant glucagon response to intravenous arginine. *P < 0.001 vs. basal, ANOVA; n = 4. B: Incremental glucagon responses to hypoglycemia from baseline to 180 min of the islet transplant recipients (•), type 1 diabetic subjects (▵), and nondiabetic control subjects (○). The mean incremental responses of the islet transplant recipients and the type 1 diabetic subjects did not differ significantly, but both were significantly less than that of nondiabetic control subjects. *P < 0.05 vs. control, ANOVA.

This Article

  1. Diabetes vol. 51 no. 12 3428-3434