Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence

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FIG. 4.FIG. 4.
FIG. 4.

A: Plasma epinephrine response during hypoglycemic clamp of islet transplant recipients (•), type 1 diabetic subjects (▵), and nondiabetic control subjects (○). A significant rise in plasma epinephrine was observed in the control group. Two islet transplant recipients had elevations of plasma epinephrine, but overall there was no significant rise in mean plasma epinephrine in the islet transplant group or the type 1 diabetic group. *P < 0.001 vs. basal, ANOVA. B: Incremental epinephrine responses to hypoglycemia from baseline to 180 min of the islet transplant recipients (•), type 1 diabetic subjects (▵), and nondiabetic control subjects (○). The mean incremental responses of the islet transplant recipients and the type 1 diabetic subjects did not differ significantly, and both were significantly less than that of the nondiabetic control subjects. *P < 0.05 vs. control, ANOVA.

This Article

  1. Diabetes vol. 51 no. 12 3428-3434