Table of Contents

Rapid Publication

Select this article
- Andrew B. Adams,
- Nozomu Shirasugi,
- Megan M. Durham,
- Elizabeth Strobert,
- Dan Anderson,
- Phyllis Rees,
- Shannon Cowan,
- Huaying Xu,
- Yelena Blinder,
- Michael Cheung,
- Dianne Hollenbaugh,
- Norma S. Kenyon,
- Thomas C. Pearson,
- and Christian P. Larsen
Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates
Diabetes February 2002 51:265-270; published ahead of print January 4, 2002, doi:10.2337/diabetes.51.2.265
Select this article
- Silvana Obici,
- Zhaohui Feng,
- Kimyata Morgan,
- Daniel Stein,
- George Karkanias,
- and Luciano Rossetti
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Diabetes February 2002 51:271-275; published ahead of print December 20, 2001, doi:10.2337/diabetes.51.2.271

Metabolism and Signal Transduction

Select this article
- Boli Huang,
- Pengfei Wu,
- Melissa M. Bowker-Kinley,
- and Robert A. Harris
Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin
Diabetes February 2002 51:276-283; doi:10.2337/diabetes.51.2.276
Select this article
- Jørgen F.P. Wojtaszewski,
- Sebastian B. Jørgensen,
- Ylva Hellsten,
- D. Grahame Hardie,
- and Erik A. Richter
Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle
Diabetes February 2002 51:284-292; doi:10.2337/diabetes.51.2.284
Select this article
- Fatima Smih,
- Philippe Rouet,
- Stéphanie Lucas,
- Aline Mairal,
- Coralie Sengenes,
- Max Lafontan,
- Sophie Vaulont,
- Marta Casado,
- and Dominique Langin
Transcriptional Regulation of Adipocyte Hormone-Sensitive Lipase by Glucose
Diabetes February 2002 51:293-300; doi:10.2337/diabetes.51.2.293
Select this article
- Pankaj Shah,
- Adrian Vella,
- Ananda Basu,
- Rita Basu,
- Aron Adkins,
- W. Frederick Schwenk,
- C. Michael Johnson,
- K. Sreekumaran Nair,
- Michael D. Jensen,
- and Robert A. Rizza
Effects of Free Fatty Acids and Glycerol on Splanchnic Glucose Metabolism and Insulin Extraction in Nondiabetic Humans
Diabetes February 2002 51:301-310; doi:10.2337/diabetes.51.2.301

Immunology and Transplantation

Select this article
- Helen E. Thomas,
- Rima Darwiche,
- John A. Corbett,
- and Thomas W.H. Kay
Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production
Diabetes February 2002 51:311-316; doi:10.2337/diabetes.51.2.311
Select this article
- Lee Carpenter,
- Damien Cordery,
- and Trevor J. Biden
Inhibition of Protein Kinase C δ Protects Rat INS-1 Cells Against Interleukin-1β and Streptozotocin-Induced Apoptosis
Diabetes February 2002 51:317-324; doi:10.2337/diabetes.51.2.317
Select this article
- Shari Thiessen,
- Pau Serra,
- Abdelaziz Amrani,
- Joan Verdaguer,
- and Pere Santamaria
T-Cell Tolerance by Dendritic Cells and Macrophages as a Mechanism for the Major Histocompatibility Complex-Linked Resistance to Autoimmune Diabetes
Diabetes February 2002 51:325-338; doi:10.2337/diabetes.51.2.325
Select this article
- Werner Gurr,
- Reza Yavari,
- Li Wen,
- Margaret Shaw,
- Conchi Mora,
- Laurence Christa,
- and Robert S. Sherwin
A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice
Diabetes February 2002 51:339-346; doi:10.2337/diabetes.51.2.339
Select this article
- Jon D. Piganelli,
- Sonia C. Flores,
- Coral Cruz,
- Jeffrey Koepp,
- Ines Batinic-Haberle,
- James Crapo,
- Brian Day,
- Remy Kachadourian,
- Rebekah Young,
- Brenda Bradley,
- and Kathryn Haskins
A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone
Diabetes February 2002 51:347-355; doi:10.2337/diabetes.51.2.347
Select this article
- Angela M. Alexander,
- Megan Crawford,
- Suzanne Bertera,
- William A. Rudert,
- Osamu Takikawa,
- Paul D. Robbins,
- and Massimo Trucco
Indoleamine 2,3-Dioxygenase Expression in Transplanted NOD Islets Prolongs Graft Survival After Adoptive Transfer of Diabetogenic Splenocytes
Diabetes February 2002 51:356-365; doi:10.2337/diabetes.51.2.356

Islet Studies

Select this article
- Françoise Van Eylen,
- Oscar Diaz Horta,
- Aurore Barez,
- Adama Kamagate,
- Peter R. Flatt,
- Regina Macianskiene,
- Kanigula Mubagwa,
- and André Herchuelz
Overexpression of the Na/Ca Exchanger Shapes Stimulus-Induced Cytosolic Ca²⁺ Oscillations in Insulin-Producing BRIN-BD11 Cells
Diabetes February 2002 51:366-375; doi:10.2337/diabetes.51.2.366
Select this article
- Jean-François Rolland,
- Jean-Claude Henquin,
- and Patrick Gilon
Feedback Control of the ATP-Sensitive K⁺ Current by Cytosolic Ca²⁺ Contributes to Oscillations of the Membrane Potential in Pancreatic β-Cells
Diabetes February 2002 51:376-384; doi:10.2337/diabetes.51.2.376
Select this article
- Frédérique Béringue,
- Bertrand Blondeau,
- Marie Claire Castellotti,
- Bernadette Bréant,
- Paul Czernichow,
- and Michel Polak
Endocrine Pancreas Development in Growth-Retarded Human Fetuses
Diabetes February 2002 51:385-391; doi:10.2337/diabetes.51.2.385
Select this article
- Patricia Serradas,
- Luis Goya,
- Matthieu Lacorne,
- Marie-Noëlle Gangnerau,
- Sonia Ramos,
- Carmen Alvarez,
- Ana-Maria Pascual-Leone,
- and Bernard Portha
Fetal Insulin-Like Growth Factor-2 Production Is Impaired in the GK Rat Model of Type 2 Diabetes
Diabetes February 2002 51:392-397; doi:10.2337/diabetes.51.2.392
Select this article
- Gene C. Webb,
- Murtaza S. Akbar,
- Chongjian Zhao,
- Hewson H. Swift,
- and Donald F. Steiner
Glucagon Replacement via Micro-Osmotic Pump Corrects Hypoglycemia and α-Cell Hyperplasia in Prohormone Convertase 2 Knockout Mice
Diabetes February 2002 51:398-405; doi:10.2337/diabetes.51.2.398
Select this article
- Stéphane Dalle,
- Ghislaine Fontés,
- Anne-Dominique Lajoix,
- Laurence LeBrigand,
- René Gross,
- Gérard Ribes,
- Michel Dufour,
- Léo Barry,
- Dung LeNguyen,
- and Dominique Bataille
Miniglucagon (Glucagon 19-29): A Novel Regulator of the Pancreatic Islet Physiology
Diabetes February 2002 51:406-412; doi:10.2337/diabetes.51.2.406
Select this article
- D. Ross Laybutt,
- Hideaki Kaneto,
- Wendy Hasenkamp,
- Shane Grey,
- Jean-Christophe Jonas,
- Dennis C. Sgroi,
- Adam Groff,
- Christiane Ferran,
- Susan Bonner-Weir,
- Arun Sharma,
- and Gordon C. Weir
Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia
Diabetes February 2002 51:413-423; doi:10.2337/diabetes.51.2.413
Select this article
- Claus B. Juhl,
- Malene Hollingdal,
- Jeppe Sturis,
- Grethe Jakobsen,
- Henrik Agersø,
- Johannes Veldhuis,
- Niels Pørksen,
- and Ole Schmitz
Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes
Diabetes February 2002 51:424-429; doi:10.2337/diabetes.51.2.424

Pathophysiology

Select this article
- Takashi Sakurai,
- Bo Yang,
- Toshihiro Takata,
- and Koichi Yokono
Synaptic Adaptation to Repeated Hypoglycemia Depends on the Utilization of Monocarboxylates in Guinea Pig Hippocampal Slices
Diabetes February 2002 51:430-438; doi:10.2337/diabetes.51.2.430
Select this article
- Marcelo L.G. Correia,
- William G. Haynes,
- Kamal Rahmouni,
- Donald A. Morgan,
- William I. Sivitz,
- and Allyn L. Mark
The Concept of Selective Leptin Resistance: Evidence From Agouti Yellow Obese Mice
Diabetes February 2002 51:439-442; doi:10.2337/diabetes.51.2.439
Select this article
- Young-Bum Kim,
- Theodore P. Ciaraldi,
- Alice Kong,
- Dennis Kim,
- Neelima Chu,
- Pharis Mohideen,
- Sunder Mudaliar,
- Robert R. Henry,
- and Barbara B. Kahn
Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
Diabetes February 2002 51:443-448; doi:10.2337/diabetes.51.2.443
Select this article
- Jesper Franch,
- Jens Knudsen,
- Bronwyn A. Ellis,
- Preben K. Pedersen,
- Gregory J. Cooney,
- and Jørgen Jensen
Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat
Diabetes February 2002 51:449-454; doi:10.2337/diabetes.51.2.449
Select this article
- Barbora Vozarova,
- Christian Weyer,
- Robert S. Lindsay,
- Richard E. Pratley,
- Clifton Bogardus,
- and P. Antonio Tataranni
High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes
Diabetes February 2002 51:455-461; doi:10.2337/diabetes.51.2.455
Select this article
- Thongchai Pratipanawatr,
- Kenneth Cusi,
- Peter Ngo,
- Wilailak Pratipanawatr,
- Lawrence J. Mandarino,
- and Ralph A. DeFronzo
Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes
Diabetes February 2002 51:462-468; doi:10.2337/diabetes.51.2.462
Select this article
- Masakazu Shiota,
- Mary Courtney Moore,
- Pietro Galassetti,
- Michael Monohan,
- Doss W. Neal,
- Gerald I. Shulman,
- and Alan D. Cherrington
Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog
Diabetes February 2002 51:469-478; doi:10.2337/diabetes.51.2.469
Select this article
- Kirsten F. Howlett,
- Kei Sakamoto,
- Michael F. Hirshman,
- William G. Aschenbach,
- Matthew Dow,
- Morris F. White,
- and Laurie J. Goodyear
Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice
Diabetes February 2002 51:479-483; doi:10.2337/diabetes.51.2.479
Select this article
- Ingvar Ek,
- Peter Arner,
- Mikael Rydén,
- Cecilia Holm,
- Anders Thörne,
- Johan Hoffstedt,
- and Hans Wahrenberg
A Unique Defect in the Regulation of Visceral Fat Cell Lipolysis in the Polycystic Ovary Syndrome as an Early Link to Insulin Resistance
Diabetes February 2002 51:484-492; doi:10.2337/diabetes.51.2.484

Complications

Select this article
- Mikko J. Järvisalo,
- Anne Putto-Laurila,
- Laura Jartti,
- Terho Lehtimäki,
- Tiina Solakivi,
- Tapani Rönnemaa,
- and Olli T. Raitakari
Carotid Artery Intima-Media Thickness in Children With Type 1 Diabetes
Diabetes February 2002 51:493-498; doi:10.2337/diabetes.51.2.493
Select this article
- Alessia Fornoni,
- Liliane J. Striker,
- Feng Zheng,
- and Gary E. Striker
Reversibility of Glucose-Induced Changes in Mesangial Cell Extracellular Matrix Depends on the Genetic Background
Diabetes February 2002 51:499-505; doi:10.2337/diabetes.51.2.499
Select this article
- M. Luiza Caramori,
- Youngki Kim,
- Chunmei Huang,
- Alfred J. Fish,
- Stephen S. Rich,
- Michael E. Miller,
- Greg Russell,
- and Michael Mauer
Cellular Basis of Diabetic Nephropathy: 1. Study Design and Renal Structural-Functional Relationships in Patients With Long-Standing Type 1 Diabetes
Diabetes February 2002 51:506-513; doi:10.2337/diabetes.51.2.506
Select this article
- Pal Pacher,
- Lucas Liaudet,
- Francisco Garcia Soriano,
- Jon G. Mabley,
- Éva Szabó,
- and Csaba Szabó
The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes
Diabetes February 2002 51:514-521; doi:10.2337/diabetes.51.2.514
Select this article
- Yong K. Kim,
- Mi-S. Lee,
- Seok M. Son,
- In J. Kim,
- Won S. Lee,
- Byung Y. Rhim,
- Ki W. Hong,
- and Chi D. Kim
Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes
Diabetes February 2002 51:522-527; doi:10.2337/diabetes.51.2.522
Select this article
- S.C. Elbein and
- S.J. Hasstedt
Quantitative Trait Linkage Analysis of Lipid-Related Traits in Familial Type 2 Diabetes: Evidence for Linkage of Triglyceride Levels to Chromosome 19q
Diabetes February 2002 51:528-535; doi:10.2337/diabetes.51.2.528

Genetics

Select this article
- Kazuo Hara,
- Philippe Boutin,
- Yasumichi Mori,
- Kazuyuki Tobe,
- Christian Dina,
- Kazuki Yasuda,
- Toshimasa Yamauchi,
- Shuichi Otabe,
- Terumasa Okada,
- Kazuhiro Eto,
- Hiroko Kadowaki,
- Ryoko Hagura,
- Yasuo Akanuma,
- Yoshio Yazaki,
- Ryozo Nagai,
- Matsuo Taniyama,
- Koichi Matsubara,
- Madoka Yoda,
- Yasuko Nakano,
- Satoshi Kimura,
- Motowo Tomita,
- Satoshi Kimura,
- Chikako Ito,
- Philippe Froguel,
- and Takashi Kadowaki
Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population
Diabetes February 2002 51:536-540; doi:10.2337/diabetes.51.2.536
Select this article
- Xiaofeng Zhu,
- Richard S. Cooper,
- Amy Luke,
- Guanjie Chen,
- Xiaodong Wu,
- Donghui Kan,
- Aravinda Chakravarti,
- and Alan Weder
A Genome-Wide Scan for Obesity in African-Americans
Diabetes February 2002 51:541-544; doi:10.2337/diabetes.51.2.541
Select this article
- Yumiko Kawabata,
- Hiroshi Ikegami,
- Yoshihiko Kawaguchi,
- Tomomi Fujisawa,
- Maki Shintani,
- Masaya Ono,
- Masanori Nishino,
- Yasuko Uchigata,
- Inkyu Lee,
- and Toshio Ogihara
Asian-Specific HLA Haplotypes Reveal Heterogeneity of the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Type 1 Diabetes.
Diabetes February 2002 51:545-551; doi:10.2337/diabetes.51.2.545

Erratum

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Erratum
Diabetes February 2002 51:552; doi:10.2337/diabetes.51.2.552

Diabetes

Rapid Publication

Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Metabolism and Signal Transduction

Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin

Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle

Transcriptional Regulation of Adipocyte Hormone-Sensitive Lipase by Glucose

Effects of Free Fatty Acids and Glycerol on Splanchnic Glucose Metabolism and Insulin Extraction in Nondiabetic Humans

Immunology and Transplantation

Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production

Inhibition of Protein Kinase C δ Protects Rat INS-1 Cells Against Interleukin-1β and Streptozotocin-Induced Apoptosis

T-Cell Tolerance by Dendritic Cells and Macrophages as a Mechanism for the Major Histocompatibility Complex-Linked Resistance to Autoimmune Diabetes

A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Indoleamine 2,3-Dioxygenase Expression in Transplanted NOD Islets Prolongs Graft Survival After Adoptive Transfer of Diabetogenic Splenocytes

Islet Studies

Overexpression of the Na/Ca Exchanger Shapes Stimulus-Induced Cytosolic Ca2+ Oscillations in Insulin-Producing BRIN-BD11 Cells

Feedback Control of the ATP-Sensitive K+ Current by Cytosolic Ca2+ Contributes to Oscillations of the Membrane Potential in Pancreatic β-Cells

Endocrine Pancreas Development in Growth-Retarded Human Fetuses

Fetal Insulin-Like Growth Factor-2 Production Is Impaired in the GK Rat Model of Type 2 Diabetes

Glucagon Replacement via Micro-Osmotic Pump Corrects Hypoglycemia and α-Cell Hyperplasia in Prohormone Convertase 2 Knockout Mice

Miniglucagon (Glucagon 19-29): A Novel Regulator of the Pancreatic Islet Physiology

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Pathophysiology

Synaptic Adaptation to Repeated Hypoglycemia Depends on the Utilization of Monocarboxylates in Guinea Pig Hippocampal Slices

The Concept of Selective Leptin Resistance: Evidence From Agouti Yellow Obese Mice

Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects

Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog

Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice

A Unique Defect in the Regulation of Visceral Fat Cell Lipolysis in the Polycystic Ovary Syndrome as an Early Link to Insulin Resistance

Complications

Carotid Artery Intima-Media Thickness in Children With Type 1 Diabetes

Reversibility of Glucose-Induced Changes in Mesangial Cell Extracellular Matrix Depends on the Genetic Background

Cellular Basis of Diabetic Nephropathy: 1. Study Design and Renal Structural-Functional Relationships in Patients With Long-Standing Type 1 Diabetes

The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes

Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes

Quantitative Trait Linkage Analysis of Lipid-Related Traits in Familial Type 2 Diabetes: Evidence for Linkage of Triglyceride Levels to Chromosome 19q

Genetics

Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population

A Genome-Wide Scan for Obesity in African-Americans

Asian-Specific HLA Haplotypes Reveal Heterogeneity of the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Type 1 Diabetes.

Erratum

Erratum

This Issue

Current Issue

Issue Highlights

Overexpression of the Na/Ca Exchanger Shapes Stimulus-Induced Cytosolic Ca²⁺ Oscillations in Insulin-Producing BRIN-BD11 Cells

Feedback Control of the ATP-Sensitive K⁺ Current by Cytosolic Ca²⁺ Contributes to Oscillations of the Membrane Potential in Pancreatic β-Cells