Table of Contents

April 2002; 51 (4)

Metabolism and Signal Transduction

Select this article
- Ilan Gabriely,
- Meredith Hawkins,
- Cristian Vilcu,
- Luciano Rossetti,
- and Harry Shamoon
Fructose Amplifies Counterregulatory Responses to Hypoglycemia in Humans
Diabetes April 2002 51:893-900; doi:10.2337/diabetes.51.4.893
Select this article
- Deborah M. Muoio,
- James M. Way,
- Charles J. Tanner,
- Deborah A. Winegar,
- Steven A. Kliewer,
- Joseph A. Houmard,
- William E. Kraus,
- and G. Lynis Dohm
Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells
Diabetes April 2002 51:901-909; doi:10.2337/diabetes.51.4.901
Select this article
- Hiromi Iwahashi,
- Kazuya Yamagata,
- Issei Yoshiuchi,
- Jungo Terasaki,
- Qin Yang,
- Kenji Fukui,
- Arisa Ihara,
- Qian Zhu,
- Takeshi Asakura,
- Yang Cao,
- Akihisa Imagawa,
- Mitsuyoshi Namba,
- Toshiaki Hanafusa,
- Jun-ichiro Miyagawa,
- and Yuji Matsuzawa
Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α
Diabetes April 2002 51:910-914; doi:10.2337/diabetes.51.4.910
Select this article
- Cheol S. Choi,
- Felix N. Lee,
- Alicia A. McDonough,
- and Jang H. Youn
Independent Regulation of In Vivo Insulin Action on Glucose Versus K⁺ Uptake by Dietary Fat and K⁺ Content
Diabetes April 2002 51:915-920; doi:10.2337/diabetes.51.4.915
Select this article
- Michael Gaster,
- Ingrid Petersen,
- Kurt Højlund,
- Pernille Poulsen,
- and Henning Beck-Nielsen
The Diabetic Phenotype Is Conserved in Myotubes Established From Diabetic Subjects: Evidence for Primary Defects in Glucose Transport and Glycogen Synthase Activity
Diabetes April 2002 51:921-927; doi:10.2337/diabetes.51.4.921
Select this article
- Joshua C. Anthony,
- Ali K. Reiter,
- Tracy G. Anthony,
- Stephen J. Crozier,
- Charles H. Lang,
- David A. MacLean,
- Scot R. Kimball,
- and Leonard S. Jefferson
Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation
Diabetes April 2002 51:928-936; doi:10.2337/diabetes.51.4.928
Select this article
- Paul W. Hruz,
- Haruhiko Murata,
- Haijun Qiu,
- and Mike Mueckler
Indinavir Induces Acute and Reversible Peripheral Insulin Resistance in Rats
Diabetes April 2002 51:937-942; doi:10.2337/diabetes.51.4.937

Obesity Studies

Select this article
- J.A. Pospisilik,
- S.G. Stafford,
- H-U. Demuth,
- R. Brownsey,
- W. Parkhouse,
- D.T. Finegood,
- C.H.S. McIntosh,
- and R.A. Pederson
Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats
Diabetes April 2002 51:943-950; doi:10.2337/diabetes.51.4.943
Select this article
- Carla J. Greenbaum,
- Ronald L. Prigeon,
- and David A. D’Alessio
Impaired β-Cell Function, Incretin Effect, and Glucagon Suppression in Patients With Type 1 Diabetes Who Have Normal Fasting Glucose
Diabetes April 2002 51:951-957; doi:10.2337/diabetes.51.4.951
Select this article
- Salomon Banarer,
- Veronica P. McGregor,
- and Philip E. Cryer
Intraislet Hyperinsulinemia Prevents the Glucagon Response to Hypoglycemia Despite an Intact Autonomic Response
Diabetes April 2002 51:958-965; doi:10.2337/diabetes.51.4.958
Select this article
- Melissa K. Lingohr,
- Lorna M. Dickson,
- Jill F. McCuaig,
- Sigrun R. Hugl,
- Daniel R. Twardzik,
- and Christopher J. Rhodes
Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation
Diabetes April 2002 51:966-976; doi:10.2337/diabetes.51.4.966
Select this article
- Anna K. Busch,
- Damien Cordery,
- Gareth S. Denyer,
- and Trevor J. Biden
Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function
Diabetes April 2002 51:977-987; doi:10.2337/diabetes.51.4.977
Select this article
- Jian-Man Lin,
- Marta E. Fabregat,
- Ramon Gomis,
- and Peter Bergsten
Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes
Diabetes April 2002 51:988-993; doi:10.2337/diabetes.51.4.988
Select this article
- Lukas Günther,
- Pascal O. Berberat,
- Manabu Haga,
- Sophie Brouard,
- R. Neal Smith,
- Miguel P. Soares,
- Fritz H. Bach,
- and Edda Tobiasch
Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation
Diabetes April 2002 51:994-999; doi:10.2337/diabetes.51.4.994

Genetics

Select this article
- Henrik B.T. Christesen,
- Bendt B. Jacobsen,
- Stella Odili,
- Carol Buettger,
- Antonio Cuesta-Munoz,
- Torben Hansen,
- Klaus Brusgaard,
- Ornella Massa,
- Mark A. Magnuson,
- Chiyo Shiota,
- Franz M. Matschinsky,
- and Fabrizio Barbetti
The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy
Diabetes April 2002 51:1240-1246; doi:10.2337/diabetes.51.4.1240
Select this article
- Yasumichi Mori,
- Shuichi Otabe,
- Christian Dina,
- Kazuki Yasuda,
- Céline Populaire,
- Cécile Lecoeur,
- Vincent Vatin,
- Emmanuelle Durand,
- Kazuo Hara,
- Terumasa Okada,
- Kazuyuki Tobe,
- Philippe Boutin,
- Takashi Kadowaki,
- and Philippe Froguel
Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p
Diabetes April 2002 51:1247-1255; doi:10.2337/diabetes.51.4.1247

Epidemiology

Select this article
- Rita Peila,
- Beatriz L. Rodriguez,
- and Lenore J. Launer
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study
Diabetes April 2002 51:1256-1262; doi:10.2337/diabetes.51.4.1256
Select this article
- Anthony J.G. Hanley,
- Ralph D’Agostino, Jr.,
- Lynne E. Wagenknecht,
- Mohammed F. Saad,
- Peter J. Savage,
- Richard Bergman,
- and Steven M. Haffner
Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study
Diabetes April 2002 51:1263-1270; doi:10.2337/diabetes.51.4.1263
Select this article
- Christine B. Jensen,
- Heidi Storgaard,
- Flemming Dela,
- Jens Juul Holst,
- Sten Madsbad,
- and Allan A. Vaag
Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight
Diabetes April 2002 51:1271-1280; doi:10.2337/diabetes.51.4.1271

Brief Genetics Reports

Select this article
- Harald Esterbauer,
- Hannes Oberkofler,
- Veronika Linnemayr,
- Bernhard Iglseder,
- Margot Hedegger,
- Peter Wolfsgruber,
- Bernhard Paulweber,
- Gerd Fastner,
- Franz Krempler,
- and Wolfgang Patsch
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women
Diabetes April 2002 51:1281-1286; doi:10.2337/diabetes.51.4.1281
Select this article
- Jayne A.L. Minton,
- Andrew T. Hattersley,
- Katharine Owen,
- Mark I. McCarthy,
- Mark Walker,
- Farida Latif,
- Timothy Barrett,
- and Timothy M. Frayling
Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations
Diabetes April 2002 51:1287-1290; doi:10.2337/diabetes.51.4.1287
Select this article
- Kirsten Heathcote,
- Anna Rajab,
- Jocelyne Magré,
- Petros Syrris,
- Mehran Besti,
- Michael Patton,
- Marc Délépine,
- Mark Lathrop,
- Jacqueline Capeau,
- and Steve Jeffery
Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman: Evidence for Multiple Loci
Diabetes April 2002 51:1291-1293; doi:10.2337/diabetes.51.4.1291

Erratum

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Errata
Diabetes April 2002 51:1294; doi:10.2337/diabetes.51.4.1294
Select this article

Errata
Diabetes April 2002 51:1294; doi:10.2337/diabetes.51.4.1294-a

Current Issue

May 2013, 62 (5)

Print ISSN: 0012-1797
Online ISSN: 1939-327X

Diabetes

Metabolism and Signal Transduction

Fructose Amplifies Counterregulatory Responses to Hypoglycemia in Humans

Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Independent Regulation of In Vivo Insulin Action on Glucose Versus K+ Uptake by Dietary Fat and K+ Content

The Diabetic Phenotype Is Conserved in Myotubes Established From Diabetic Subjects: Evidence for Primary Defects in Glucose Transport and Glycogen Synthase Activity

Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation

Indinavir Induces Acute and Reversible Peripheral Insulin Resistance in Rats

Obesity Studies

Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

Impaired β-Cell Function, Incretin Effect, and Glucagon Suppression in Patients With Type 1 Diabetes Who Have Normal Fasting Glucose

Intraislet Hyperinsulinemia Prevents the Glucagon Response to Hypoglycemia Despite an Intact Autonomic Response

Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation

Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes

Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation

Pathophysiology

Blood Letting in High-Ferritin Type 2 Diabetes: Effects on Insulin Sensitivity and β-Cell Function

The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations: Distinct Metabolic Effects of Two Fat Compartments

Leptin Resistance During Aging Is Independent of Fat Mass

Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity

Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor-α

Novel Genes Regulated by the Insulin Sensitizer Rosiglitazone During Adipocyte Differentiation

Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol-3′ Kinase Activation, and Impaired Atypical Protein Kinase C (ζ/λ) Activation in Myotubes From Obese Patients With Impaired Glucose Tolerance

Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures

Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome

Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat

A Tailored Therapy for the Metabolic Syndrome: The Dual Peroxisome Proliferator-Activated Receptor-α/γ Agonist LY465608 Ameliorates Insulin Resistance and Diabetic Hyperglycemia While Improving Cardiovascular Risk Factors in Preclinical Models

Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes: The Leiden 85-Plus Study

Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity

Decreased Expression of Heat Shock Protein 72 In Skeletal Muscle of Patients With Type 2 Diabetes Correlates With Insulin Resistance

Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

Complications

Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes: Protection by Allopurinol

Dose-Dependent Vasodilating Effects of Insulin on Adenosine-Stimulated Myocardial Blood Flow

Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo

Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes: Progressive, Interrelated, and Independently Associated With Risk of Death

Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Improves Myocardial Contractility in Diabetic Cardiomyopathy

Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients

Homocysteine Induces Protein Kinase C Activation and Stimulates c-Fos and Lipoprotein Lipase Expression in Macrophages

Polymorphism in Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 Gene (ENPP1/PC-1) and Early Development of Advanced Diabetic Nephropathy in Type 1 Diabetes

Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells: Implications for Diabetes-Associated Cardiovascular Disease

ATP-Dependent K+ Channels Contribute to Local Metabolic Coronary Vasodilation in Experimental Diabetes

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

Early Decrease of Skin Blood Flow in Response to Locally Applied Pressure in Diabetic Subjects

Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization

Abnormalities of Glucose Metabolism in Patients With Early Renal Failure

Hepatic Expression of Microsomal Triglyceride Transfer Protein and In Vivo Secretion of Triglyceride-Rich Lipoproteins Are Increased in Obese Diabetic Mice

Genetics

The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy

Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

Epidemiology

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study

Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study

Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight

Brief Genetics Reports

Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women

Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman: Evidence for Multiple Loci

Erratum

Errata

Errata

This Issue

Current Issue

Issue Highlights

Independent Regulation of In Vivo Insulin Action on Glucose Versus K⁺ Uptake by Dietary Fat and K⁺ Content

Assessment of Skeletal Muscle Triglyceride Content by ¹H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity

Overexpression of the Sarcoplasmic Reticulum Ca²⁺-ATPase Improves Myocardial Contractility in Diabetic Cardiomyopathy

ATP-Dependent K⁺ Channels Contribute to Local Metabolic Coronary Vasodilation in Experimental Diabetes