Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

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FIG. 3.
FIG. 3.

Risk of developing type 2 diabetes (logistic regression analysis). A: ORs and 95% CIs for a 1 SD increase in levels of log PAI-1 at baseline. ORs (95% CI) were 1.99 (1.60–2.45) for model A, 1.80 (1.45–2.25) for model B, 1.60 (1.27–2.01) for model C, 1.69 (1.35–2.12) for model D, 1.71 (1.36–2.16) for model E, and 1.61 (1.20–2.16) for model F (extended model includes as covariates age, sex, clinical center, smoking, ethnicity, SI, BMI, family history of diabetes, and physical activity). P = 0.0001 for all, except model F (P = 0.002). B: ORs and 95% CIs for a 1 SD increase in levels of log CRP at baseline. ORs (95% CI) for CRP were 1.44 (1.20–1.72; P = 0.0001) for model A, 1.34 (1.11–1.61; P = 0.003) for model B, 1.12 (0.91–1.38; P = 0.3) for model C, 1.17 (0.95–1.43; P = 0.14) for model D, and 1.20 (0.98–1.47; P = 0.08) for model E. C: ORs and 95% CIs for a 1 SD increase in levels of fibrinogen at baseline. ORs (95% CI) for fibrinogen were 1.21 (1.01–1.44; P = 0.03) for model A, 1.17 (0.97–1.40; P = 0.10) for model B, 1.01 (0.83–1.22; P = 0.9) for model C, 1.02 (0.85–1.24; P = 0.8) for model D, and 1.03 (0.85–1.25; P = 0.7) for model E.

This Article

  1. Diabetes vol. 51 no. 4 1131-1137