Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

TABLE 1

Descriptive data stratified by converters to type 2 diabetes (DM) versus nonconverters (Non-DM) in the IRAS

DM Non-DM P value
n 144 903
Ethnicity (NHW, Blacks, His) 37/28/35 41/26/33 NS
Glucose tolerance (NGT/IGT) 32/68 71/29 0.001
Hypertension (yes/no) 45/55 30/70 0.001
Sex (F/M) 60/40 56/44 NS
Age (years) 56.0 ± 7.8 54.6 ± 8.5 0.047
BMI (kg/m2) 31.1 ± 6.3 28.0 ± 5.5 0.0001
Waist circumference (cm) 95.5 ± 13.1 89.8 ± 12.7 0.0001
Fasting insulin (pmol/l) 133.4 ± 154.3 88.6 ± 69.6 0.0007
Fasting glucose (mg/dl) 106.6 ± 12.0 97.5 ± 10.8 0.0001
SI × 10−4 (min−1 · μU−1 · ml−1) 1.26 ± 1.56 2.31 ± 2.06 0.0001
Fibrinogen (mg/dl) 287.8 ± 58.8 275.1 ± 56.1 0.013
CRP (mg/l) 2.40 (1.29–5.87) 1.67 (0.75–3.41) 0.0001
PAI-1 (ng/ml) 24 (15–37.5) 16 (9–27) 0.0001
  • Data are means ± SD, and median (interquartile range). P values are for χ2, t test, or Kruskal-Wallis test as appropriate. NHW, non-Hispanic whites, His, Hispanics.

This Article

  1. Diabetes vol. 51 no. 4 1131-1137