Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes

TABLE 4

Logistic regression analysis with incident type 2 diabetes as the dependent variable stratified by BMI [below (lean) and above (obese) the median = 27.4 kg/m2]

Covariates Lean
Obese
OR (95% Cl) P value OR (95% Cl) P value
Log CRP
 A. Demographic 1.47 (1.06–2.05) 0.021 1.10 (0.86–1.41) 0.5
 B. Demographic + fasting insulin 1.46 (1.05–2.05) 0.027 1.04 (0.81–1.34) 0.8
 C. Demographic + SI 1.25 (0.88–1.79) 0.22 0.93 (0.70–1.22) 0.6
Log PAI-1
 A. Demographic 2.02 (1.39–2.93) 0.0002 1.67 (1.27–2.20) 0.0003
 B. Demographic + fasting insulin 1.89 (1.30–2.75) 0.0009 1.56 (1.18–2.08) 0.0022
 C. Demographic + SI 1.72 (1.17–2.54) 0.0063 1.48 (1.10–2.00) 0.0098
Fibrinogen
 A. Demographic 1.32 (0.94–1.85) 0.11 1.00 (0.80–1.26) 0.9
 B. Demographic + fasting insulin 1.34 (0.96–1.88) 0.09 0.98 (0.78–1.24) 0.9
 C. Demographic + SI 1.12 (0.78–1.59) 0.5 0.89 (0.70–1.14) 0.9
  • *

    * Demographic model includes as covariates age, sex, clinical center, and smoking.

This Article

  1. Diabetes vol. 51 no. 4 1131-1137