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Table of Contents
May 2002; 51 (5)
Perspectives in Diabetes
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Md. Shahidul Islam
The Ryanodine Receptor Calcium Channel of β-Cells
:
Molecular Regulation and Physiological Significance
Diabetes
May 2002
51
:
1299
-
1309
;
doi:
10.2337/diabetes.51.5.1299
Abstract
Full Text
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Metabolism and Signal Transduction
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Robert H. Coker
,
Yoshiharu Koyama
,
Joshua C. Denny
,
Raul C. Camacho
,
D. Brooks Lacy
,
and
David H. Wasserman
Prevention of Overt Hypoglycemia During Exercise
:
Stimulation of Endogenous Glucose Production Independent of Hepatic Catecholamine Action and Changes in Pancreatic Hormone Concentration
Diabetes
May 2002
51
:
1310
-
1318
;
doi:
10.2337/diabetes.51.5.1310
Abstract
Full Text
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Hong Ruan
,
Nir Hacohen
,
Todd R. Golub
,
Luk Van Parijs
,
and
Harvey F. Lodish
Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes
:
Nuclear Factor-κB Activation by TNF-α Is Obligatory
Diabetes
May 2002
51
:
1319
-
1336
;
doi:
10.2337/diabetes.51.5.1319
Abstract
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Obesity
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Dominique D. Pierroz
,
Mary Ziotopoulou
,
Linda Ungsunan
,
Stergios Moschos
,
Jeffrey S. Flier
,
and
Christos S. Mantzoros
Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity
Diabetes
May 2002
51
:
1337
-
1345
;
doi:
10.2337/diabetes.51.5.1337
Abstract
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Immunology
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Jinko Graham
,
William A. Hagopian
,
Ingrid Kockum
,
Lou Sheng Li
,
Carani B. Sanjeevi
,
Robert M. Lowe
,
Jonathan B. Schaefer
,
Marjan Zarghami
,
Heather L. Day
,
Mona Landin-Olsson
,
Jerry P. Palmer
,
Marta Janer-Villanueva
,
Leroy Hood
,
Göran Sundkvist
,
Åke Lernmark
,
Norman Breslow
,
Gisela Dahlquist
,
and
Göran Blohmé
Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes
Diabetes
May 2002
51
:
1346
-
1355
;
doi:
10.2337/diabetes.51.5.1346
Abstract
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Giuseppe Matarese
,
Veronica Sanna
,
Robert I. Lechler
,
Nora Sarvetnick
,
Silvia Fontana
,
Serafino Zappacosta
,
and
Antonio La Cava
Leptin Accelerates Autoimmune Diabetes in Female NOD Mice
Diabetes
May 2002
51
:
1356
-
1361
;
doi:
10.2337/diabetes.51.5.1356
Abstract
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Göran Mattsson
,
Leif Jansson
,
and
Per-Ola Carlsson
Decreased Vascular Density in Mouse Pancreatic Islets After Transplantation
Diabetes
May 2002
51
:
1362
-
1366
;
doi:
10.2337/diabetes.51.5.1362
Abstract
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Silvia Gregori
,
Nadia Giarratana
,
Simona Smiroldo
,
Milan Uskokovic
,
and
Luciano Adorini
A 1α,25-Dihydroxyvitamin D
3
Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice
Diabetes
May 2002
51
:
1367
-
1374
;
doi:
10.2337/diabetes.51.5.1367
Abstract
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Helena Reijonen
,
Erik J. Novak
,
Sharon Kochik
,
Anne Heninger
,
Andrew W. Liu
,
William W. Kwok
,
and
Gerald T. Nepom
Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects
Diabetes
May 2002
51
:
1375
-
1382
;
doi:
10.2337/diabetes.51.5.1375
Abstract
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Aziz Alami Chentoufi
and
Constantin Polychronakos
Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance
:
The Mechanism by Which the
IDDM2
Locus May Predispose to Diabetes
Diabetes
May 2002
51
:
1383
-
1390
;
doi:
10.2337/diabetes.51.5.1383
Abstract
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Maki Nakayama
,
Masao Nagata
,
Hisafumi Yasuda
,
Kenji Arisawa
,
Reiko Kotani
,
Katsumi Yamada
,
Shahead Ali Chowdhury
,
Sagarika Chakrabarty
,
Zhen Zi Jin
,
Hideo Yagita
,
Koichi Yokono
,
and
Masato Kasuga
Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes
Diabetes
May 2002
51
:
1391
-
1397
;
doi:
10.2337/diabetes.51.5.1391
Abstract
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Islet Studies
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Hideto Kojima
,
Takaaki Nakamura
,
Yukihiro Fujita
,
Akio Kishi
,
Mineko Fujimiya
,
Syu Yamada
,
Motoi Kudo
,
Yoshihiko Nishio
,
Hiroshi Maegawa
,
Masakazu Haneda
,
Hitoshi Yasuda
,
Itaru Kojima
,
Masaharu Seno
,
Norman C.W. Wong
,
Ryuichi Kikkawa
,
and
Atsunori Kashiwagi
Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin
Diabetes
May 2002
51
:
1398
-
1408
;
doi:
10.2337/diabetes.51.5.1398
Abstract
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Nobuhiro Ban
,
Yuichiro Yamada
,
Yoshimichi Someya
,
Kazumasa Miyawaki
,
Yu Ihara
,
Masaya Hosokawa
,
Shinya Toyokuni
,
Kinsuke Tsuda
,
and
Yutaka Seino
Hepatocyte Nuclear Factor-1α Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter
Diabetes
May 2002
51
:
1409
-
1418
;
doi:
10.2337/diabetes.51.5.1409
Abstract
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Junzhi Ji
,
Shao-Nian Yang
,
Xiaohang Huang
,
Xidan Li
,
Laura Sheu
,
Nicholas Diamant
,
Per-Olof Berggren
,
and
Herbert Y. Gaisano
Modulation of L-Type Ca
2+
Channels by Distinct Domains Within SNAP-25
Diabetes
May 2002
51
:
1425
-
1436
;
doi:
10.2337/diabetes.51.5.1425
Abstract
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Roberto Lupi
,
Francesco Dotta
,
Lorella Marselli
,
Silvia Del Guerra
,
Matilde Masini
,
Carmela Santangelo
,
Giovanni Patané
,
Ugo Boggi
,
Salvatore Piro
,
Marcello Anello
,
Ettore Bergamini
,
Franco Mosca
,
Umberto Di Mario
,
Stefano Del Prato
,
and
Piero Marchetti
Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets
:
Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated
Diabetes
May 2002
51
:
1437
-
1442
;
doi:
10.2337/diabetes.51.5.1437
Abstract
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Cécile Tourrel
,
Danielle Bailbe
,
Matthieu Lacorne
,
Marie-Jo Meile
,
Micheline Kergoat
,
and
Bernard Portha
Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4
Diabetes
May 2002
51
:
1443
-
1452
;
doi:
10.2337/diabetes.51.5.1443
Abstract
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Manami Tsutsumi
,
Thomas H. Claus
,
Yin Liang
,
Yaxin Li
,
Ling Yang
,
Jian Zhu
,
Fernando Dela Cruz
,
Xianbu Peng
,
Hongxing Chen
,
Stephanie L. Yung
,
Sarah Hamren
,
James N. Livingston
,
and
Clark Q. Pan
A Potent and Highly Selective VPAC2 Agonist Enhances Glucose-Induced Insulin Release and Glucose Disposal
:
A Potential Therapy for Type 2 Diabetes
Diabetes
May 2002
51
:
1453
-
1460
;
doi:
10.2337/diabetes.51.5.1453
Abstract
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Béatrice Sudre
,
Pierre Broqua
,
Richard B. White
,
Doreen Ashworth
,
D. Michael Evans
,
Robert Haigh
,
Jean-Louis Junien
,
and
Michel L. Aubert
Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats
Diabetes
May 2002
51
:
1461
-
1469
;
doi:
10.2337/diabetes.51.5.1461
Abstract
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Brief Genetics Reports
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Piero Marchetti
,
Roberto Lupi
,
Massimo Federici
,
Lorella Marselli
,
Matilde Masini
,
Ugo Boggi
,
Silvia Del Guerra
,
Giovanni Patanè
,
Salvatore Piro
,
Marcello Anello
,
Ettore Bergamini
,
Francesco Purrello
,
Renato Lauro
,
Franco Mosca
,
Giorgio Sesti
,
and
Stefano Del Prato
Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly
972
→Arg IRS-1 Polymorphism
Diabetes
May 2002
51
:
1419
-
1424
;
doi:
10.2337/diabetes.51.5.1419
Abstract
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James C. Engert
,
Marie-Claude Vohl
,
Scott M. Williams
,
Pierre Lepage
,
J C. Loredo-Osti
,
Janet Faith
,
Carole Doré
,
Yannick Renaud
,
Noël P. Burtt
,
Amélie Villeneuve
,
Joel N. Hirschhorn
,
David Altshuler
,
Leif C. Groop
,
Jean-Pierre Després
,
Daniel Gaudet
,
and
Thomas J. Hudson
5′ Flanking Variants of Resistin Are Associated With Obesity
Diabetes
May 2002
51
:
1629
-
1634
;
doi:
10.2337/diabetes.51.5.1629
Abstract
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Takuya Awata
,
Kiyoaki Inoue
,
Susumu Kurihara
,
Tomoko Ohkubo
,
Masaki Watanabe
,
Kouichi Inukai
,
Ikuo Inoue
,
and
Shigehiro Katayama
A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Diabetes
May 2002
51
:
1635
-
1639
;
doi:
10.2337/diabetes.51.5.1635
Abstract
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Mouna Barat-Houari
,
Karine Clément
,
Vincent Vatin
,
Christian Dina
,
Geneviève Bonhomme
,
Francis Vasseur
,
Bernard Guy-Grand
,
and
Philippe Froguel
Positional Candidate Gene Analysis of Lim Domain Homeobox Gene (Isl-1) on Chromosome 5q11-q13 in a French Morbidly Obese Population Suggests Indication for Association With Type 2 Diabetes
Diabetes
May 2002
51
:
1640
-
1643
;
doi:
10.2337/diabetes.51.5.1640
Abstract
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Online Appendix
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Tasha E. Fingerlin
,
Michael R. Erdos
,
Richard M. Watanabe
,
Kerry R Wiles
,
Heather M. Stringham
,
Karen L. Mohlke
,
Kaisa Silander
,
Timo T. Valle
,
Thomas A. Buchanan
,
Jaakko Tuomilehto
,
Richard N. Bergman
,
Michael Boehnke
,
and
Francis S. Collins
Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort
Diabetes
May 2002
51
:
1644
-
1648
;
doi:
10.2337/diabetes.51.5.1644
Abstract
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Lorenza Nisticò
,
Gabriele Giorgi
,
Mara Giordano
,
Andrea Galgani
,
Antonio Petrone
,
Sandra D’Alfonso
,
Massimo Federici
,
Umberto Di Mario
,
Paolo Pozzilli
,
Raffaella Buzzetti
,
and
Isabella Cascino
IL12B
Polymorphism and Type 1 Diabetes in the Italian Population
:
A Case-Control Study
Diabetes
May 2002
51
:
1649
-
1650
;
doi:
10.2337/diabetes.51.5.1649
Abstract
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Pathophysiology
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Cristina Gonzalez
,
Josiane Ménissier de Murcia
,
Philip Janiak
,
Jean-Pierre Bidouard
,
Catherine Beauvais
,
Saoussen Karray
,
Henri-Jean Garchon
,
and
Matthieu Lévi-Strauss
Unexpected Sensitivity of Nonobese Diabetic Mice With a Disrupted Poly(ADP-Ribose) Polymerase-1 Gene to Streptozotocin-Induced and Spontaneous Diabetes
Diabetes
May 2002
51
:
1470
-
1476
;
doi:
10.2337/diabetes.51.5.1470
Abstract
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Bronwyn D. Hegarty
,
Gregory J. Cooney
,
Edward W. Kraegen
,
and
Stuart M. Furler
Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats
Diabetes
May 2002
51
:
1477
-
1484
;
doi:
10.2337/diabetes.51.5.1477
Abstract
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Veronica P. McGregor
,
Jeffrey S. Greiwe
,
Salomon Banarer
,
and
Philip E. Cryer
Limited Impact of Vigorous Exercise on Defenses Against Hypoglycemia
:
Relevance to Hypoglycemia-Associated Autonomic Failure
Diabetes
May 2002
51
:
1485
-
1492
;
doi:
10.2337/diabetes.51.5.1485
Abstract
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Philip G. McTernan
,
Alison L. Harte
,
Leah A. Anderson
,
Allan Green
,
Stephen A. Smith
,
Julie C. Holder
,
Anthony H. Barnett
,
Margaret C. Eggo
,
and
Sudhesh Kumar
Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro
Diabetes
May 2002
51
:
1493
-
1498
;
doi:
10.2337/diabetes.51.5.1493
Abstract
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Judd Boloker
,
Shira J. Gertz
,
and
Rebecca A. Simmons
Gestational Diabetes Leads to the Development of Diabetes in Adulthood in the Rat
Diabetes
May 2002
51
:
1499
-
1506
;
doi:
10.2337/diabetes.51.5.1499
Abstract
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Nassirah Khandoudi
,
Philippe Delerive
,
Isabelle Berrebi-Bertrand
,
Robin E. Buckingham
,
Bart Staels
,
and
Antoine Bril
Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ, Inhibits the Jun NH
2
-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart From Ischemia/Reperfusion Injury
Diabetes
May 2002
51
:
1507
-
1514
;
doi:
10.2337/diabetes.51.5.1507
Abstract
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Erik H. Serné
,
Richard G. IJzerman
,
Reinold O.B. Gans
,
Robin Nijveldt
,
Greetje de Vries
,
Reinder Evertz
,
Ab J.M. Donker
,
and
Coen D.A. Stehouwer
Direct Evidence for Insulin-Induced Capillary Recruitment in Skin of Healthy Subjects During Physiological Hyperinsulinemia
Diabetes
May 2002
51
:
1515
-
1522
;
doi:
10.2337/diabetes.51.5.1515
Abstract
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Complications
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Takaaki Maeno
,
Hidenori Koyama
,
Hideki Tahara
,
Miyoko Komatsu
,
Masanori Emoto
,
Tetsuo Shoji
,
Masaaki Inaba
,
Takami Miki
,
Yasuhisa Okuno
,
and
Yoshiki Nishizawa
The 807T Allele in α2 Integrin Is Protective Against Atherosclerotic Arterial Wall Thickening and the Occurrence of Plaque in Patients With Type 2 Diabetes
Diabetes
May 2002
51
:
1523
-
1528
;
doi:
10.2337/diabetes.51.5.1523
Abstract
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Lilia A. Silveira
,
Carlos E. Bacchi
,
Glauce A. Pinto
,
and
José B. Lopes de Faria
The Genetics of Hypertension Modifies the Renal Cell Replication Response Induced by Experimental Diabetes
Diabetes
May 2002
51
:
1529
-
1534
;
doi:
10.2337/diabetes.51.5.1529
Abstract
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Manuel Portero-Otín
,
Reinald Pamplona
,
Maria Josep Bellmunt
,
Maria Cristina Ruiz
,
Joan Prat
,
Robert Salvayre
,
and
Anne Nègre-Salvayre
Advanced Glycation End Product Precursors Impair Epidermal Growth Factor Receptor Signaling
Diabetes
May 2002
51
:
1535
-
1542
;
doi:
10.2337/diabetes.51.5.1535
Abstract
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Arzu Ilercil
,
Richard B. Devereux
,
Mary J. Roman
,
Mary Paranicas
,
Michael J. O’Grady
,
Elisa T. Lee
,
Thomas K. Welty
,
Richard R. Fabsitz
,
and
Barbara V. Howard
Associations of Insulin Levels With Left Ventricular Structure and Function in American Indians
:
The Strong Heart Study
Diabetes
May 2002
51
:
1543
-
1547
;
doi:
10.2337/diabetes.51.5.1543
Abstract
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Laura L. Atkinson
,
Sandra E. Kelly
,
James C. Russell
,
Jacob Bar-Tana
,
and
Gary D. Lopaschuk
MEDICA 16 Inhibits Hepatic Acetyl-CoA Carboxylase and Reduces Plasma Triacylglycerol Levels in Insulin-Resistant JCR
:
LA-cp Rats
Diabetes
May 2002
51
:
1548
-
1555
;
doi:
10.2337/diabetes.51.5.1548
Abstract
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Gregory Booth
,
Timothy J. Stalker
,
Allan M. Lefer
,
and
Rosario Scalia
Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo
Diabetes
May 2002
51
:
1556
-
1564
;
doi:
10.2337/diabetes.51.5.1556
Abstract
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Tsuyoshi Sato
,
Robert Haimovici
,
Richard Kao
,
An-Fei Li
,
and
Sayon Roy
Downregulation of Connexin 43 Expression by High Glucose Reduces Gap Junction Activity in Microvascular Endothelial Cells
Diabetes
May 2002
51
:
1565
-
1571
;
doi:
10.2337/diabetes.51.5.1565
Abstract
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Michael Mauer
and
Keith Drummond
The Early Natural History of Nephropathy in Type 1 Diabetes
:
I. Study Design and Baseline Characteristics of the Study Participants
Diabetes
May 2002
51
:
1572
-
1579
;
doi:
10.2337/diabetes.51.5.1572
Abstract
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Keith Drummond
and
Michael Mauer
The Early Natural History of Nephropathy in Type 1 Diabetes
:
II. Early Renal Structural Changes in Type 1 Diabetes
Diabetes
May 2002
51
:
1580
-
1587
;
doi:
10.2337/diabetes.51.5.1580
Abstract
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Maiko Kakimoto
,
Toyoshi Inoguchi
,
Toshiyo Sonta
,
Hai Yan Yu
,
Minako Imamura
,
Takashi Etoh
,
Toshihiko Hashimoto
,
and
Hajime Nawata
Accumulation of 8-Hydroxy-2′-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats
Diabetes
May 2002
51
:
1588
-
1595
;
doi:
10.2337/diabetes.51.5.1588
Abstract
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Dilys J. Freeman
,
John Norrie
,
Muriel J. Caslake
,
Allan Gaw
,
Ian Ford
,
Gordon D.O. Lowe
,
Denis St. J. O’Reilly
,
Chris J. Packard
,
and
Naveed Sattar
C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study
Diabetes
May 2002
51
:
1596
-
1600
;
doi:
10.2337/diabetes.51.5.1596
Abstract
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Genetics
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Mikael Rydén
,
Gary Faulds
,
Johan Hoffstedt
,
Anders Wennlund
,
and
Peter Arner
Effect of the (C825T) Gβ
3
Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells
Diabetes
May 2002
51
:
1601
-
1608
;
doi:
10.2337/diabetes.51.5.1601
Abstract
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Cecilia M. Lindgren
,
Elisabeth Widén
,
Tiinamaija Tuomi
,
Haiyan Li
,
Peter Almgren
,
Timo Kanninen
,
Olle Melander
,
Jianping Weng
,
Markku Lehto
,
and
Leif C. Groop
Contribution of Known and Unknown Susceptibility Genes to Early-Onset Diabetes in Scandinavia
:
Evidence for Heterogeneity
Diabetes
May 2002
51
:
1609
-
1617
;
doi:
10.2337/diabetes.51.5.1609
Abstract
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Web Appendices 1 and 2
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Peter Kovacs
,
Xiaolin Yang
,
Paska A. Permana
,
Clifton Bogardus
,
and
Leslie J. Baier
Polymorphisms in the Oxygen-Regulated Protein 150 Gene (
ORP150
) Are Associated With Insulin Resistance in Pima Indians
Diabetes
May 2002
51
:
1618
-
1621
;
doi:
10.2337/diabetes.51.5.1618
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Paul G. Cassell
,
Alan E. Jackson
,
Bernard V. North
,
Julie C. Evans
,
Denise Syndercombe-Court
,
Chris Phillips
,
Ambady Ramachandran
,
Chamukuttan Snehalatha
,
Susan V. Gelding
,
Shanti Vijayaravaghan
,
David Curtis
,
and
Graham A. Hitman
Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians
Diabetes
May 2002
51
:
1622
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1628
;
doi:
10.2337/diabetes.51.5.1622
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Daniel W. Foster
John Denis McGarry, PhD
Diabetes
May 2002
51
:
1651
;
doi:
10.2337/diabetes.51.5.1651
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Diabetes
May 2002
51
:
1652
;
doi:
10.2337/diabetes.51.5.1652
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Diabetes
May 2002
51
:
1652
;
doi:
10.2337/diabetes.51.5.1652-a
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May 2002;
51
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Perspectives in Diabetes
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