Table of Contents

• Md. Shahidul Islam

The Ryanodine Receptor Calcium Channel of β-Cells: Molecular Regulation and Physiological Significance

• Robert H. Coker,
• Yoshiharu Koyama,
• Joshua C. Denny,
• Raul C. Camacho,
• D. Brooks Lacy,
• and David H. Wasserman

Prevention of Overt Hypoglycemia During Exercise: Stimulation of Endogenous Glucose Production Independent of Hepatic Catecholamine Action and Changes in Pancreatic Hormone Concentration

• Hong Ruan,
• Nir Hacohen,
• Todd R. Golub,
• Luk Van Parijs,
• and Harvey F. Lodish

Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes: Nuclear Factor-κB Activation by TNF-α Is Obligatory

• Dominique D. Pierroz,
• Mary Ziotopoulou,
• Linda Ungsunan,
• Stergios Moschos,
• Jeffrey S. Flier,
• and Christos S. Mantzoros

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

• Jinko Graham,
• William A. Hagopian,
• Ingrid Kockum,
• Lou Sheng Li,
• Carani B. Sanjeevi,
• Robert M. Lowe,
• Jonathan B. Schaefer,
• Marjan Zarghami,
• Heather L. Day,
• Mona Landin-Olsson,
• Jerry P. Palmer,
• Marta Janer-Villanueva,
• Leroy Hood,
• Göran Sundkvist,
• Åke Lernmark,
• Norman Breslow,
• Gisela Dahlquist,
• and Göran Blohmé

Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes

• Giuseppe Matarese,
• Veronica Sanna,
• Robert I. Lechler,
• Nora Sarvetnick,
• Silvia Fontana,
• Serafino Zappacosta,
• and Antonio La Cava

Leptin Accelerates Autoimmune Diabetes in Female NOD Mice

• Göran Mattsson,
• Leif Jansson,
• and Per-Ola Carlsson

Decreased Vascular Density in Mouse Pancreatic Islets After Transplantation

• Silvia Gregori,
• Nadia Giarratana,
• Simona Smiroldo,
• Milan Uskokovic,
• and Luciano Adorini

A 1α,25-Dihydroxyvitamin D₃ Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice

• Helena Reijonen,
• Erik J. Novak,
• Sharon Kochik,
• Anne Heninger,
• Andrew W. Liu,
• William W. Kwok,
• and Gerald T. Nepom

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

• Aziz Alami Chentoufi and
• Constantin Polychronakos

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance: The Mechanism by Which the IDDM2 Locus May Predispose to Diabetes

• Maki Nakayama,
• Masao Nagata,
• Hisafumi Yasuda,
• Kenji Arisawa,
• Reiko Kotani,
• Katsumi Yamada,
• Shahead Ali Chowdhury,
• Sagarika Chakrabarty,
• Zhen Zi Jin,
• Hideo Yagita,
• Koichi Yokono,
• and Masato Kasuga

Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes

• Hideto Kojima,
• Takaaki Nakamura,
• Yukihiro Fujita,
• Akio Kishi,
• Mineko Fujimiya,
• Syu Yamada,
• Motoi Kudo,
• Yoshihiko Nishio,
• Hiroshi Maegawa,
• Masakazu Haneda,
• Hitoshi Yasuda,
• Itaru Kojima,
• Masaharu Seno,
• Norman C.W. Wong,
• Ryuichi Kikkawa,
• and Atsunori Kashiwagi

Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin

• Nobuhiro Ban,
• Yuichiro Yamada,
• Yoshimichi Someya,
• Kazumasa Miyawaki,
• Yu Ihara,
• Masaya Hosokawa,
• Shinya Toyokuni,
• Kinsuke Tsuda,
• and Yutaka Seino

Hepatocyte Nuclear Factor-1α Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter

• Junzhi Ji,
• Shao-Nian Yang,
• Xiaohang Huang,
• Xidan Li,
• Laura Sheu,
• Nicholas Diamant,
• Per-Olof Berggren,
• and Herbert Y. Gaisano

Modulation of L-Type Ca²⁺ Channels by Distinct Domains Within SNAP-25

• Roberto Lupi,
• Francesco Dotta,
• Lorella Marselli,
• Silvia Del Guerra,
• Matilde Masini,
• Carmela Santangelo,
• Giovanni Patané,
• Ugo Boggi,
• Salvatore Piro,
• Marcello Anello,
• Ettore Bergamini,
• Franco Mosca,
• Umberto Di Mario,
• Stefano Del Prato,
• and Piero Marchetti

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

• Cécile Tourrel,
• Danielle Bailbe,
• Matthieu Lacorne,
• Marie-Jo Meile,
• Micheline Kergoat,
• and Bernard Portha

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

• Manami Tsutsumi,
• Thomas H. Claus,
• Yin Liang,
• Yaxin Li,
• Ling Yang,
• Jian Zhu,
• Fernando Dela Cruz,
• Xianbu Peng,
• Hongxing Chen,
• Stephanie L. Yung,
• Sarah Hamren,
• James N. Livingston,
• and Clark Q. Pan

A Potent and Highly Selective VPAC2 Agonist Enhances Glucose-Induced Insulin Release and Glucose Disposal: A Potential Therapy for Type 2 Diabetes

• Béatrice Sudre,
• Pierre Broqua,
• Richard B. White,
• Doreen Ashworth,
• D. Michael Evans,
• Robert Haigh,
• Jean-Louis Junien,
• and Michel L. Aubert

Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats

• Piero Marchetti,
• Roberto Lupi,
• Massimo Federici,
• Lorella Marselli,
• Matilde Masini,
• Ugo Boggi,
• Silvia Del Guerra,
• Giovanni Patanè,
• Salvatore Piro,
• Marcello Anello,
• Ettore Bergamini,
• Francesco Purrello,
• Renato Lauro,
• Franco Mosca,
• Giorgio Sesti,
• and Stefano Del Prato

Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly⁹⁷²→Arg IRS-1 Polymorphism

• James C. Engert,
• Marie-Claude Vohl,
• Scott M. Williams,
• Pierre Lepage,
• J C. Loredo-Osti,
• Janet Faith,
• Carole Doré,
• Yannick Renaud,
• Noël P. Burtt,
• Amélie Villeneuve,
• Joel N. Hirschhorn,
• David Altshuler,
• Leif C. Groop,
• Jean-Pierre Després,
• Daniel Gaudet,
• and Thomas J. Hudson

5′ Flanking Variants of Resistin Are Associated With Obesity

• Takuya Awata,
• Kiyoaki Inoue,
• Susumu Kurihara,
• Tomoko Ohkubo,
• Masaki Watanabe,
• Kouichi Inukai,
• Ikuo Inoue,
• and Shigehiro Katayama

A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes

• Mouna Barat-Houari,
• Karine Clément,
• Vincent Vatin,
• Christian Dina,
• Geneviève Bonhomme,
• Francis Vasseur,
• Bernard Guy-Grand,
• and Philippe Froguel

Positional Candidate Gene Analysis of Lim Domain Homeobox Gene (Isl-1) on Chromosome 5q11-q13 in a French Morbidly Obese Population Suggests Indication for Association With Type 2 Diabetes

• Tasha E. Fingerlin,
• Michael R. Erdos,
• Richard M. Watanabe,
• Kerry R Wiles,
• Heather M. Stringham,
• Karen L. Mohlke,
• Kaisa Silander,
• Timo T. Valle,
• Thomas A. Buchanan,
• Jaakko Tuomilehto,
• Richard N. Bergman,
• Michael Boehnke,
• and Francis S. Collins

Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort

• Lorenza Nisticò,
• Gabriele Giorgi,
• Mara Giordano,
• Andrea Galgani,
• Antonio Petrone,
• Sandra D’Alfonso,
• Massimo Federici,
• Umberto Di Mario,
• Paolo Pozzilli,
• Raffaella Buzzetti,
• and Isabella Cascino

IL12B Polymorphism and Type 1 Diabetes in the Italian Population: A Case-Control Study

• Cristina Gonzalez,
• Josiane Ménissier de Murcia,
• Philip Janiak,
• Jean-Pierre Bidouard,
• Catherine Beauvais,
• Saoussen Karray,
• Henri-Jean Garchon,
• and Matthieu Lévi-Strauss

Unexpected Sensitivity of Nonobese Diabetic Mice With a Disrupted Poly(ADP-Ribose) Polymerase-1 Gene to Streptozotocin-Induced and Spontaneous Diabetes

• Bronwyn D. Hegarty,
• Gregory J. Cooney,
• Edward W. Kraegen,
• and Stuart M. Furler

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats

• Veronica P. McGregor,
• Jeffrey S. Greiwe,
• Salomon Banarer,
• and Philip E. Cryer

Limited Impact of Vigorous Exercise on Defenses Against Hypoglycemia: Relevance to Hypoglycemia-Associated Autonomic Failure

• Philip G. McTernan,
• Alison L. Harte,
• Leah A. Anderson,
• Allan Green,
• Stephen A. Smith,
• Julie C. Holder,
• Anthony H. Barnett,
• Margaret C. Eggo,
• and Sudhesh Kumar

Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro

• Judd Boloker,
• Shira J. Gertz,
• and Rebecca A. Simmons

Gestational Diabetes Leads to the Development of Diabetes in Adulthood in the Rat

• Nassirah Khandoudi,
• Philippe Delerive,
• Isabelle Berrebi-Bertrand,
• Robin E. Buckingham,
• Bart Staels,
• and Antoine Bril

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ, Inhibits the Jun NH₂-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart From Ischemia/Reperfusion Injury

• Erik H. Serné,
• Richard G. IJzerman,
• Reinold O.B. Gans,
• Robin Nijveldt,
• Greetje de Vries,
• Reinder Evertz,
• Ab J.M. Donker,
• and Coen D.A. Stehouwer

Direct Evidence for Insulin-Induced Capillary Recruitment in Skin of Healthy Subjects During Physiological Hyperinsulinemia

• Takaaki Maeno,
• Hidenori Koyama,
• Hideki Tahara,
• Miyoko Komatsu,
• Masanori Emoto,
• Tetsuo Shoji,
• Masaaki Inaba,
• Takami Miki,
• Yasuhisa Okuno,
• and Yoshiki Nishizawa

The 807T Allele in α2 Integrin Is Protective Against Atherosclerotic Arterial Wall Thickening and the Occurrence of Plaque in Patients With Type 2 Diabetes

• Lilia A. Silveira,
• Carlos E. Bacchi,
• Glauce A. Pinto,
• and José B. Lopes de Faria

The Genetics of Hypertension Modifies the Renal Cell Replication Response Induced by Experimental Diabetes

• Manuel Portero-Otín,
• Reinald Pamplona,
• Maria Josep Bellmunt,
• Maria Cristina Ruiz,
• Joan Prat,
• Robert Salvayre,
• and Anne Nègre-Salvayre

Advanced Glycation End Product Precursors Impair Epidermal Growth Factor Receptor Signaling

• Arzu Ilercil,
• Richard B. Devereux,
• Mary J. Roman,
• Mary Paranicas,
• Michael J. O’Grady,
• Elisa T. Lee,
• Thomas K. Welty,
• Richard R. Fabsitz,
• and Barbara V. Howard

Associations of Insulin Levels With Left Ventricular Structure and Function in American Indians: The Strong Heart Study

• Laura L. Atkinson,
• Sandra E. Kelly,
• James C. Russell,
• Jacob Bar-Tana,
• and Gary D. Lopaschuk

MEDICA 16 Inhibits Hepatic Acetyl-CoA Carboxylase and Reduces Plasma Triacylglycerol Levels in Insulin-Resistant JCR: LA-cp Rats

• Gregory Booth,
• Timothy J. Stalker,
• Allan M. Lefer,
• and Rosario Scalia

Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo

• Tsuyoshi Sato,
• Robert Haimovici,
• Richard Kao,
• An-Fei Li,
• and Sayon Roy

Downregulation of Connexin 43 Expression by High Glucose Reduces Gap Junction Activity in Microvascular Endothelial Cells

• Michael Mauer and
• Keith Drummond

The Early Natural History of Nephropathy in Type 1 Diabetes: I. Study Design and Baseline Characteristics of the Study Participants

• Keith Drummond and
• Michael Mauer

The Early Natural History of Nephropathy in Type 1 Diabetes: II. Early Renal Structural Changes in Type 1 Diabetes

• Maiko Kakimoto,
• Toyoshi Inoguchi,
• Toshiyo Sonta,
• Hai Yan Yu,
• Minako Imamura,
• Takashi Etoh,
• Toshihiko Hashimoto,
• and Hajime Nawata

Accumulation of 8-Hydroxy-2′-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats

• Dilys J. Freeman,
• John Norrie,
• Muriel J. Caslake,
• Allan Gaw,
• Ian Ford,
• Gordon D.O. Lowe,
• Denis St. J. O’Reilly,
• Chris J. Packard,
• and Naveed Sattar

C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study

• Mikael Rydén,
• Gary Faulds,
• Johan Hoffstedt,
• Anders Wennlund,
• and Peter Arner

Effect of the (C825T) Gβ₃ Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells

• Cecilia M. Lindgren,
• Elisabeth Widén,
• Tiinamaija Tuomi,
• Haiyan Li,
• Peter Almgren,
• Timo Kanninen,
• Olle Melander,
• Jianping Weng,
• Markku Lehto,
• and Leif C. Groop

Contribution of Known and Unknown Susceptibility Genes to Early-Onset Diabetes in Scandinavia: Evidence for Heterogeneity

• Peter Kovacs,
• Xiaolin Yang,
• Paska A. Permana,
• Clifton Bogardus,
• and Leslie J. Baier

Polymorphisms in the Oxygen-Regulated Protein 150 Gene (ORP150) Are Associated With Insulin Resistance in Pima Indians

• Paul G. Cassell,
• Alan E. Jackson,
• Bernard V. North,
• Julie C. Evans,
• Denise Syndercombe-Court,
• Chris Phillips,
• Ambady Ramachandran,
• Chamukuttan Snehalatha,
• Susan V. Gelding,
• Shanti Vijayaravaghan,
• David Curtis,
• and Graham A. Hitman

Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians

• Daniel W. Foster

John Denis McGarry, PhD

Errata

Errata