IL12B Polymorphism and Type 1 Diabetes in the Italian Population
A Case-Control Study
- Lorenza Nisticò1,
- Gabriele Giorgi12,
- Mara Giordano3,
- Andrea Galgani2,
- Antonio Petrone2,
- Sandra D’Alfonso3,
- Massimo Federici4,
- Umberto Di Mario2,
- Paolo Pozzilli5,
- Raffaella Buzzetti2 and
- Isabella Cascino1
- 1Institute of Cell Biology, CNR, Campus Buzzati-Traverso, Monterotondo, Rome, Italy
- 2Department of Clinical Science, Division of Endocrinology, University of Rome “La Sapienza”, Rome, Italy
- 3Department of Medical Science, Eastern Piedmont University, Novara, Italy
- 4Department of Internal Medicine, University of Tor Vergata, Rome, Italy
- 5Libera Università Campo Biomedico, Rome, Italy
Abstract
A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease.
Footnotes
-
Address correspondence and reprint requests to Lorenza Nisticò, Institute of Cell Biology, CNR, Campus Buzzati-Traverso, Via E. Ramarini 32, Monterotondo 00016, Rome, Italy. E-mail: lnistico{at}ibc.rm.cnr.it.
Received for publication 9 January 2002 and accepted in revised form 11 February 2002.
AFBAC, affected family-based control subject; LD, linkage disequilibrium; UTR, untranslated region.
- DIABETES
