Table of Contents

• John J. Rogus,
• James H. Warram,
• and Andrzej S. Krolewski

Genetic Studies of Late Diabetic Complications: The Overlooked Importance of Diabetes Duration Before Complication Onset

• Shosuke Satake,
• Mary Courtney Moore,
• Kayano Igawa,
• Margaret Converse,
• Benjamin Farmer,
• Doss W. Neal,
• and Alan D. Cherrington

Direct and Indirect Effects of Insulin on Glucose Uptake and Storage by the Liver

• Michihiro Matsumoto,
• Wataru Ogawa,
• Kiyoshi Teshigawara,
• Hiroshi Inoue,
• Kazuaki Miyake,
• Hiroshi Sakaue,
• and Masato Kasuga

Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes

• Owen Chan,
• Stephen Chan,
• Karen Inouye,
• Kathy Shum,
• Stephen G. Matthews,
• and Mladen Vranic

Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses

• Alberto Battezzati,
• Andrea Caumo,
• Annalisa Fattorini,
• Lucia Piceni Sereni,
• Jorgelina Coppa,
• Raffaele Romito,
• Mario Ammatuna,
• Enrico Regalia,
• Vincenzo Mazzaferro,
• and Livio Luzi

Amino Acid Kinetics During the Anhepatic Phase of Liver Transplantation

• Jürgen Janke,
• Stefan Engeli,
• Kerstin Gorzelniak,
• Friedrich C. Luft,
• and Arya M. Sharma

Mature Adipocytes Inhibit In Vitro Differentiation of Human Preadipocytes via Angiotensin Type 1 Receptors

• Ian J. Waterman and
• Victor A. Zammit

Differential Effects of Fenofibrate or Simvastatin Treatment of Rats on Hepatic Microsomal Overt and Latent Diacylglycerol Acyltransferase Activities

• Lorraine Brennan,
• Aine Shine,
• Chandralal Hewage,
• J. Paul G. Malthouse,
• Kevin M. Brindle,
• Neville McClenaghan,
• Peter R. Flatt,
• and Philip Newsholme

A Nuclear Magnetic Resonance-Based Demonstration of Substantial Oxidative l-Alanine Metabolism and l-Alanine-Enhanced Glucose Metabolism in a Clonal Pancreatic β-Cell Line : Metabolism of l-Alanine Is Important to the Regulation of Insulin Secretion

• Isabelle Guillet-Deniau,
• Virginie Mieulet,
• Soazig Le Lay,
• Younes Achouri,
• Denis Carré,
• Jean Girard,
• Fabienne Foufelle,
• and Pascal Ferré

Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression

• Michael G. Dube,
• Elena Beretta,
• Harveen Dhillon,
• Naohiko Ueno,
• Pushpa S. Kalra,
• and Satya P. Kalra

Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia: Increase in Serum Ghrelin Levels

• Nobuhiro Shojima,
• Hideyuki Sakoda,
• Takehide Ogihara,
• Midori Fujishiro,
• Hideki Katagiri,
• Motonobu Anai,
• Yukiko Onishi,
• Hiraku Ono,
• Kouichi Inukai,
• Miho Abe,
• Yasushi Fukushima,
• Masatoshi Kikuchi,
• Yoshitomo Oka,
• and Tomoichiro Asano

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells

• Ruben Varela-Calvino,
• Richard Ellis,
• Gianluca Sgarbi,
• Colin M. Dayan,
• and Mark Peakman

Characterization of the T-Cell Response to Coxsackievirus B4: Evidence That Effector Memory Cells Predominate in Patients With Type 1 Diabetes

• Henrik Borg,
• Anders Gottsäter,
• Per Fernlund,
• and Göran Sundkvist

A 12-Year Prospective Study of the Relationship Between Islet Antibodies and β-Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes

• Steven D. Chessler,
• William T. Simonson,
• Ian R. Sweet,
• and Lisa P. Hammerle

Expression of the Vesicular Inhibitory Amino Acid Transporter in Pancreatic Islet Cells: Distribution of the Transporter Within Rat Islets

• Phuong Oanh T. Tran,
• Catherine E. Gleason,
• and R. Paul Robertson

Inhibition of Interleukin-1β-Induced COX-2 and EP3 Gene Expression by Sodium Salicylate Enhances Pancreatic Islet β-Cell Function

• Lisa Özmen,
• Kristina Nilsson Ekdahl,
• Graciela Elgue,
• Rolf Larsson,
• Olle Korsgren,
• and Bo Nilsson

Inhibition of Thrombin Abrogates the Instant Blood-Mediated Inflammatory Reaction Triggered by Isolated Human Islets: Possible Application of the Thrombin Inhibitor Melagatran in Clinical Islet Transplantation

• Qin Yang,
• Kazuya Yamagata,
• Kenji Fukui,
• Yang Cao,
• Takao Nammo,
• Hiromi Iwahashi,
• Haiyan Wang,
• Itaru Matsumura,
• Toshiaki Hanafusa,
• Richard Bucala,
• Claes B. Wollheim,
• Jun-ichiro Miyagawa,
• and Yuji Matsuzawa

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

• D. Ross Laybutt,
• Gordon C. Weir,
• Hideaki Kaneto,
• Judith Lebet,
• Richard D. Palmiter,
• Arun Sharma,
• and Susan Bonner-Weir

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

• Sandra Cottet,
• Philippe Dupraz,
• Fabienne Hamburger,
• Wanda Dolci,
• Muriel Jaquet,
• and Bernard Thorens

cFLIP Protein Prevents Tumor Necrosis Factor-α–Mediated Induction of Caspase-8–Dependent Apoptosis in Insulin-Secreting βTc-Tet Cells

• Oscar Diaz-Horta,
• Adama Kamagate,
• André Herchuelz,
• and Françoise Van Eylen

Na/Ca Exchanger Overexpression Induces Endoplasmic Reticulum–Related Apoptosis and Caspase-12 Activation in Insulin-Releasing BRIN-BD11 Cells

• Robert L. Dobbins,
• Lidia S. Szczepaniak,
• Jeff Myhill,
• Yoshifumi Tamura,
• Hiroshi Uchino,
• Adria Giacca,
• and J. Denis McGarry

The Composition of Dietary Fat Directly Influences Glucose-Stimulated Insulin Secretion in Rats

• Mark Lipsett and
• Diane T. Finegood

β-Cell Neogenesis During Prolonged Hyperglycemia in Rats

• Keiichi Saeki,
• Min Zhu,
• Atsutaka Kubosaki,
• Jingping Xie,
• Michael S. Lan,
• and Abner Louis Notkins

Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion

• Anoja S. Attele,
• Yun-Ping Zhou,
• Jing-Tian Xie,
• Ji An Wu,
• Liu Zhang,
• Lucy Dey,
• William Pugh,
• Paul A. Rue,
• Kenneth S. Polonsky,
• and Chun-Su Yuan

Antidiabetic Effects of Panax ginseng Berry Extract and the Identification of an Effective Component

• Ken Walder,
• Lakshmi Kantham,
• Janine S. McMillan,
• James Trevaskis,
• Lyndal Kerr,
• Andrea de Silva,
• Terry Sunderland,
• Nathan Godde,
• Yuan Gao,
• Natalie Bishara,
• Kelly Windmill,
• Janette Tenne-Brown,
• Guy Augert,
• Paul Z. Zimmet,
• and Greg R. Collier

Tanis: A Link Between Type 2 Diabetes and Inflammation?

• André Carpentier,
• Bruce W. Patterson,
• Nathalie Leung,
• and Gary F. Lewis

Sensitivity to Acute Insulin-Mediated Suppression of Plasma Free Fatty Acids Is Not a Determinant of Fasting VLDL Triglyceride Secretion in Healthy Humans

• Haiyan Xu,
• K. Teoman Uysal,
• J. David Becherer,
• Peter Arner,
• and Gökhan S. Hotamisligil

Altered Tumor Necrosis Factor-α (TNF-α) Processing in Adipocytes and Increased Expression of Transmembrane TNF-α in Obesity

• Norbert Stefan,
• Barbora Vozarova,
• Tohru Funahashi,
• Yuji Matsuzawa,
• Christian Weyer,
• Robert S. Lindsay,
• Jack F. Youngren,
• Peter J. Havel,
• Richard E. Pratley,
• Clifton Bogardus,
• and P. Antonio Tataranni

Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans

• Barbora Vozarova,
• Norbert Stefan,
• Robert S. Lindsay,
• Aramesh Saremi,
• Richard E. Pratley,
• Clifton Bogardus,
• and P. Antonio Tataranni

High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

• Michael Dabrowski,
• Frances M. Ashcroft,
• Rebecca Ashfield,
• Philippe Lebrun,
• Bernard Pirotte,
• Jan Egebjerg,
• John Bondo Hansen,
• and Philip Wahl

The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy-4H-1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener

• Andrea Hevener,
• Donna Reichart,
• Andrej Janez,
• and Jerrold Olefsky

Female Rats Do Not Exhibit Free Fatty Acid–Induced Insulin Resistance

• Raghavakaimal Sreekumar,
• Panagiotis Halvatsiotis,
• Jill Coenen Schimke,
• and K. Sreekumaran Nair

Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment

• Tovit Rosenzweig,
• Liora Braiman,
• Asia Bak,
• Addy Alt,
• Toshio Kuroki,
• and Sanford R. Sampson

Differential Effects of Tumor Necrosis Factor-α on Protein Kinase C Isoforms α and δ Mediate Inhibition of Insulin Receptor Signaling

• Carol A. Gunnett,
• Donald D. Heistad,
• and Frank M. Faraci

Interleukin-10 Protects Nitric Oxide–Dependent Relaxation During Diabetes: Role of Superoxide

• Lu Cai,
• Wei Li,
• Guangwu Wang,
• Luping Guo,
• Youchun Jiang,
• and Y. James Kang

Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c–Mediated Caspase-3 Activation Pathway

• Helen M. Colhoun,
• James D. Otvos,
• Mike B. Rubens,
• M. R. Taskinen,
• S. Richard Underwood,
• and John H. Fuller

Lipoprotein Subclasses and Particle Sizes and Their Relationship With Coronary Artery Calcification in Men and Women With and Without Type 1 Diabetes

• Charlene E. Hafer-Macko,
• Frederick M. Ivey,
• Kymberly A. Gyure,
• John D. Sorkin,
• and Richard F. Macko

Thrombomodulin Deficiency in Human Diabetic Nerve Microvasculature

• Hong Yin,
• Anna-Karin Berg,
• Torsten Tuvemo,
• and Gun Frisk

Enterovirus RNA Is Found in Peripheral Blood Mononuclear Cells in a Majority of Type 1 Diabetic Children at Onset

• Lars Hornum,
• John Rømer,
• and Helle Markholst

The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4, a Positional Candidate of Iddm1

• Najiba Lahlou,
• Tarik Issad,
• Yves Lebouc,
• Jean-Claude Carel,
• Luc Camoin,
• Marc Roger,
• and Jean Girard

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation

• Yan Feng,
• Tianhua Niu,
• Xin Xu,
• Changzhong Chen,
• Qiongfang Li,
• Rongli Qian,
• Guoying Wang,
• and Xiping Xu

Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes

• R. Arlen Price,
• Wei-Dong Li,
• and Robin Kilker

An X-Chromosome Scan Reveals a Locus for Fat Distribution in Chromosome Region Xp21–22

Erratum