Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes
- Yan Feng12,
- Tianhua Niu3,
- Xin Xu3,
- Changzhong Chen3,
- Qiongfang Li1,
- Rongli Qian4,
- Guoying Wang12 and
- Xiping Xu23
- 1Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China
- 2Center for Ecogenetics and Reproductive Health, Beijing University, Beijing, China
- 3Program for Popular Genetics, Harvard School of Public Health, Boston, Massachusetts
- 4Division of Endocrinology, the First Affiliated Hospital of Beijing University, Beijing, China
In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (χ21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
Address correspondence and reprint requests to Xiping Xu, MD, Associate Professor and Director, Program for Population Genetics, Harvard School of Public Health, FXB-101, 665 Huntington Ave., Boston, MA 02115-6195. E-mail:.
Received for publication 30 October 2001 and accepted in revised form 26 February 2002.
OGTT, oral glucose tolerance test.