Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes

  1. Yan Feng12,
  2. Tianhua Niu3,
  3. Xin Xu3,
  4. Changzhong Chen3,
  5. Qiongfang Li1,
  6. Rongli Qian4,
  7. Guoying Wang12 and
  8. Xiping Xu23
  1. 1Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China
  2. 2Center for Ecogenetics and Reproductive Health, Beijing University, Beijing, China
  3. 3Program for Popular Genetics, Harvard School of Public Health, Boston, Massachusetts
  4. 4Division of Endocrinology, the First Affiliated Hospital of Beijing University, Beijing, China


    In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (χ21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.


    • Address correspondence and reprint requests to Xiping Xu, MD, Associate Professor and Director, Program for Population Genetics, Harvard School of Public Health, FXB-101, 665 Huntington Ave., Boston, MA 02115-6195. E-mail: xu{at}

      Received for publication 30 October 2001 and accepted in revised form 26 February 2002.

      OGTT, oral glucose tolerance test.

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