Table of Contents

July 2002; 51 (7)

Rapid Publication

    • L. Marie Scearce,
    • John E. Brestelli,
    • Shannon K. McWeeney,
    • Catherine S. Lee,
    • Joan Mazzarelli,
    • Deborah F. Pinney,
    • Angel Pizarro,
    • Christian J. Stoeckert, Jr.,
    • Sandra W. Clifton,
    • M. Alan Permutt,
    • Juliana Brown,
    • Douglas A. Melton,
    • and Klaus H. Kaestner

    Functional Genomics of the Endocrine Pancreas: The Pancreas Clone Set and PancChip, New Resources for Diabetes Research

    Diabetes July 2002 51:1997-2004; published ahead of print June 6, 2002, doi:10.2337/diabetes.51.7.1997
    • Samar I. Itani,
    • Neil B. Ruderman,
    • Frank Schmieder,
    • and Guenther Boden

    Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

    Diabetes July 2002 51:2005-2011; published ahead of print June 6, 2002, doi:10.2337/diabetes.51.7.2005
    • Evelyne Marion,
    • Pamela Jane Kaisaki,
    • Valérie Pouillon,
    • Cyril Gueydan,
    • Jonathan C. Levy,
    • André Bodson,
    • Georges Krzentowski,
    • Jean-Claude Daubresse,
    • Jean Mockel,
    • Jens Behrends,
    • Geneviève Servais,
    • Claude Szpirer,
    • Véronique Kruys,
    • Dominique Gauguier,
    • and Stéphane Schurmans

    The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man

    Diabetes July 2002 51:2012-2017; published ahead of print June 6, 2002, doi:10.2337/diabetes.51.7.2012
    • Daisy Flamez,
    • Veerle Berger,
    • Mogens Kruhøffer,
    • Torben Orntoft,
    • Daniel Pipeleers,
    • and Frans C. Schuit

    Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release

    Diabetes July 2002 51:2018-2024; published ahead of print June 6, 2002, doi:10.2337/diabetes.51.7.2018

Perspectives in Diabetes

    • M. Cecilia Lansang and
    • Norman K. Hollenberg

    Renal Perfusion and the Renal Hemodynamic Response to Blocking the Renin System in Diabetes: Are the Forces Leading to Vasodilation and Vasoconstriction Linked?

    Diabetes July 2002 51:2025-2028; doi:10.2337/diabetes.51.7.2025

Metabolism and Signal Transduction

    • Vanessa van Harmelen,
    • Andrea Dicker,
    • Mikael Rydén,
    • Hans Hauner,
    • Fredrik Lönnqvist,
    • Erik Näslund,
    • and Peter Arner

    Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes

    Diabetes July 2002 51:2029-2036; doi:10.2337/diabetes.51.7.2029
    • Helen M. Roche,
    • Enda Noone,
    • Ciaran Sewter,
    • Siobhan Mc Bennett,
    • David Savage,
    • Michael J. Gibney,
    • Stephen O’Rahilly,
    • and Antonio J. Vidal-Puig

    Isomer-Dependent Metabolic Effects of Conjugated Linoleic Acid: Insights From Molecular Markers Sterol Regulatory Element-Binding Protein-1c and LXRα

    Diabetes July 2002 51:2037-2044; doi:10.2337/diabetes.51.7.2037
    • Yoshikazu Tamori,
    • Jiro Masugi,
    • Naonobu Nishino,
    • and Masato Kasuga

    Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes

    Diabetes July 2002 51:2045-2055; doi:10.2337/diabetes.51.7.2045
    • Ambrose A. Dunn-Meynell,
    • Vanessa H. Routh,
    • Ling Kang,
    • Larry Gaspers,
    • and Barry E. Levin

    Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons

    Diabetes July 2002 51:2056-2065; doi:10.2337/diabetes.51.7.2056
    • Beat M. Jucker,
    • Thomas R. Schaeffer,
    • Robin E. Haimbach,
    • Thomas S. McIntosh,
    • Daniel Chun,
    • Matthew Mayer,
    • Derek H. Ohlstein,
    • Hugh M. Davis,
    • Stephen A. Smith,
    • Alexander R. Cobitz,
    • and Susanta K. Sarkar

    Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty Rats: An In Vivo Nuclear Magnetic Resonance Study

    Diabetes July 2002 51:2066-2073; doi:10.2337/diabetes.51.7.2066
    • Nicolas Musi,
    • Michael F. Hirshman,
    • Jonas Nygren,
    • Monika Svanfeldt,
    • Peter Bavenholm,
    • Olav Rooyackers,
    • Gaochao Zhou,
    • Joanne M. Williamson,
    • Olle Ljunqvist,
    • Suad Efendic,
    • David E. Moller,
    • Anders Thorell,
    • and Laurie J. Goodyear

    Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

    Diabetes July 2002 51:2074-2081; doi:10.2337/diabetes.51.7.2074
    • Susanna M. Hofmann,
    • Heng-Jiang Dong,
    • Zhu Li,
    • Weijing Cai,
    • Jennifer Altomonte,
    • Swan N. Thung,
    • Feng Zeng,
    • Edward A. Fisher,
    • and Helen Vlassara

    Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse

    Diabetes July 2002 51:2082-2089; doi:10.2337/diabetes.51.7.2082
    • Carol Huang,
    • Romel Somwar,
    • Nish Patel,
    • Wenyan Niu,
    • Dóra Török,
    • and Amira Klip

    Sustained Exposure of L6 Myotubes to High Glucose and Insulin Decreases Insulin-Stimulated GLUT4 Translocation but Upregulates GLUT4 Activity

    Diabetes July 2002 51:2090-2098; doi:10.2337/diabetes.51.7.2090

Obesity Studies

    • Rexford S. Ahima,
    • Hiralben R. Patel,
    • Nobuhiko Takahashi,
    • Yong Qi,
    • Stanley M. Hileman,
    • and Michael A. Zasloff

    Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol

    Diabetes July 2002 51:2099-2104; doi:10.2337/diabetes.51.7.2099
    • Jean L. Chan,
    • Susann Blüher,
    • Nikos Yiannakouris,
    • Marc A. Suchard,
    • Jurgen Kratzsch,
    • and Christos S. Mantzoros

    Regulation of Circulating Soluble Leptin Receptor Levels By Gender, Adiposity, Sex Steroids, and Leptin: Observational and Interventional Studies in Humans

    Diabetes July 2002 51:2105-2112; doi:10.2337/diabetes.51.7.2105
    • Martin Haluzik,
    • Kelly R. Dietz,
    • Jason K. Kim,
    • Bernice Marcus-Samuels,
    • Gerald I. Shulman,
    • Oksana Gavrilova,
    • and Marc L. Reitman

    Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

    Diabetes July 2002 51:2113-2118; doi:10.2337/diabetes.51.7.2113

Immunology and Transplantation

    • Astrid G.S. van Halteren,
    • Evelyne van Etten,
    • Esther C. de Jong,
    • Roger Bouillon,
    • Bart O. Roep,
    • and Chantal Mathieu

    Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3

    Diabetes July 2002 51:2119-2125; doi:10.2337/diabetes.51.7.2119
    • David G. Alleva,
    • Amitabh Gaur,
    • Liping Jin,
    • Dale Wegmann,
    • Peter A. Gottlieb,
    • Anil Pahuja,
    • Eric B. Johnson,
    • Theresa Motheral,
    • Amy Putnam,
    • Paul D. Crowe,
    • Nicholas Ling,
    • Stefen A. Boehme,
    • and Paul J. Conlon

    Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide

    Diabetes July 2002 51:2126-2134; doi:10.2337/diabetes.51.7.2126
    • Boaz Hirshberg,
    • Sean Montgomery,
    • Michael G. Wysoki,
    • He Xu,
    • Doug Tadaki,
    • Janet Lee,
    • Kenneth Hines,
    • Jason Gaglia,
    • Noelle Patterson,
    • John Leconte,
    • Douglas Hale,
    • Richard Chang,
    • Alan D. Kirk,
    • and David M. Harlan

    Pancreatic Islet Transplantation Using the Nonhuman Primate (Rhesus) Model Predicts That the Portal Vein Is Superior to the Celiac Artery as the Islet Infusion Site

    Diabetes July 2002 51:2135-2140; doi:10.2337/diabetes.51.7.2135
    • Olivier Boulard,
    • Diane Damotte,
    • Nathalie Deruytter,
    • Guy Fluteau,
    • Claude Carnaud,
    • and Henri-Jean Garchon

    An Interval Tightly Linked to but Distinct From the H2 Complex Controls Both Overt Diabetes (Idd16) and Chronic Experimental Autoimmune Thyroiditis (Ceat1) in Nonobese Diabetic Mice

    Diabetes July 2002 51:2141-2147; doi:10.2337/diabetes.51.7.2141

Islet Studies

    • Edmond A. Ryan,
    • Jonathan R.T. Lakey,
    • Breay W. Paty,
    • Sharleen Imes,
    • Gregory S. Korbutt,
    • Norman M. Kneteman,
    • David Bigam,
    • Ray V. Rajotte,
    • and A.M. James Shapiro

    Successful Islet Transplantation: Continued Insulin Reserve Provides Long-Term Glycemic Control

    Diabetes July 2002 51:2148-2157; doi:10.2337/diabetes.51.7.2148
    • John G. Geisler,
    • Walter Zawalich,
    • Kathleen Zawalich,
    • Jonathan R.T. Lakey,
    • Hans Stukenbrok,
    • Anthony J. Milici,
    • and Walter C. Soeller

    Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide

    Diabetes July 2002 51:2158-2169; doi:10.2337/diabetes.51.7.2158

Pathophysiology

    • Christine C. Jensen,
    • Miriam Cnop,
    • Rebecca L. Hull,
    • Wilfred Y. Fujimoto,
    • Steven E. Kahn,
    • and the American Diabetes Association GENNID Study Group

    β-Cell Function Is a Major Contributor to Oral Glucose Tolerance in High-Risk Relatives of Four Ethnic Groups in the U.S.

    Diabetes July 2002 51:2170-2178; doi:10.2337/diabetes.51.7.2170
    • Meredith Hawkins,
    • Ilan Gabriely,
    • Robert Wozniak,
    • Kalpana Reddy,
    • Luciano Rossetti,
    • and Harry Shamoon

    Glycemic Control Determines Hepatic and Peripheral Glucose Effectiveness in Type 2 Diabetic Subjects

    Diabetes July 2002 51:2179-2189; doi:10.2337/diabetes.51.7.2179
    • Svetlana E. Nikoulina,
    • Theodore P. Ciaraldi,
    • Sunder Mudaliar,
    • Leslie Carter,
    • Kirk Johnson,
    • and Robert R. Henry

    Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle

    Diabetes July 2002 51:2190-2198; doi:10.2337/diabetes.51.7.2190
    • Esben S. Buhl,
    • Niels Jessen,
    • Rasmus Pold,
    • Thomas Ledet,
    • Allan Flyvbjerg,
    • Steen B. Pedersen,
    • Oluf Pedersen,
    • Ole Schmitz,
    • and Sten Lund

    Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome

    Diabetes July 2002 51:2199-2206; doi:10.2337/diabetes.51.7.2199
    • John P. Kirwan,
    • Sylvie Hauguel-De Mouzon,
    • Jacques Lepercq,
    • Jean-Claude Challier,
    • Larraine Huston-Presley,
    • Jacob E. Friedman,
    • Satish C. Kalhan,
    • and Patrick M. Catalano

    TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

    Diabetes July 2002 51:2207-2213; doi:10.2337/diabetes.51.7.2207
    • Thomas Jansson,
    • Ylva Ekstrand,
    • Caroline Björn,
    • Margareta Wennergren,
    • and Theresa L. Powell

    Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

    Diabetes July 2002 51:2214-2219; doi:10.2337/diabetes.51.7.2214
    • Patrick Schrauwen,
    • Dorien P.C. van Aggel-Leijssen,
    • Gabby Hul,
    • Anton J.M. Wagenmakers,
    • Hubert Vidal,
    • Wim H.M. Saris,
    • and Marleen A. van Baak

    The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression

    Diabetes July 2002 51:2220-2226; doi:10.2337/diabetes.51.7.2220

Complications

    • James R. Goss,
    • William F. Goins,
    • David Lacomis,
    • Marina Mata,
    • Joseph C. Glorioso,
    • and David J. Fink

    Herpes Simplex-Mediated Gene Transfer of Nerve Growth Factor Protects Against Peripheral Neuropathy in Streptozotocin-Induced Diabetes in the Mouse

    Diabetes July 2002 51:2227-2232; doi:10.2337/diabetes.51.7.2227
    • James M. Kennedy and
    • Douglas W. Zochodne

    Influence of Experimental Diabetes on the Microcirculation of Injured Peripheral Nerve: Functional and Morphological Aspects

    Diabetes July 2002 51:2233-2240; doi:10.2337/diabetes.51.7.2233
    • Giulio Romeo,
    • Wei-Hua Liu,
    • Veronica Asnaghi,
    • Timothy S. Kern,
    • and Mara Lorenzi

    Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

    Diabetes July 2002 51:2241-2248; doi:10.2337/diabetes.51.7.2241
    • Jason D. Freshwater,
    • Camilla I. Svensson,
    • Annika B. Malmberg,
    • and Nigel A. Calcutt

    Elevated Spinal Cyclooxygenase and Prostaglandin Release During Hyperalgesia in Diabetic Rats

    Diabetes July 2002 51:2249-2255; doi:10.2337/diabetes.51.7.2249
    • Najma Begum,
    • Oana A. Sandu,
    • and Noreen Duddy

    Negative Regulation of Rho Signaling by Insulin and Its Impact on Actin Cytoskeleton Organization in Vascular Smooth Muscle Cells: Role of Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Pathways

    Diabetes July 2002 51:2256-2263; doi:10.2337/diabetes.51.7.2256
    • Daniel P.K. Ng,
    • Luis Canani,
    • Shin-ichi Araki,
    • Adam Smiles,
    • Dariusz Moczulski,
    • James H. Warram,
    • and Andrzej S. Krolewski

    Minor Effect of GLUT1 Polymorphisms on Susceptibility to Diabetic Nephropathy in Type 1 Diabetes

    Diabetes July 2002 51:2264-2269; doi:10.2337/diabetes.51.7.2264
    • Ana C.P. Thirone,
    • John A. Scarlett,
    • Alessandra L. Gasparetti,
    • Eliana P. Araujo,
    • Maria H.L. Lima,
    • Carla R.O. Carvalho,
    • Lício A. Velloso,
    • and Mario J.A. Saad

    Modulation of Growth Hormone Signal Transduction in Kidneys of Streptozotocin-Induced Diabetic Animals: Effect of a Growth Hormone Receptor Antagonist

    Diabetes July 2002 51:2270-2281; doi:10.2337/diabetes.51.7.2270
    • Esko J. Wiltshire,
    • Roger Gent,
    • Craig Hirte,
    • Alexia Pena,
    • David W. Thomas,
    • and Jennifer J. Couper

    Endothelial Dysfunction Relates to Folate Status in Children and Adolescents With Type 1 Diabetes

    Diabetes July 2002 51:2282-2286; doi:10.2337/diabetes.51.7.2282
    • Sushil K. Jain,
    • Krishnaswamy Kannan,
    • Gideon Lim,
    • Robert McVie,
    • and Joseph A. Bocchini, Jr.

    Hyperketonemia Increases Tumor Necrosis Factor-α Secretion in Cultured U937 Monocytes and Type 1 Diabetic Patients and Is Apparently Mediated by Oxidative Stress and cAMP Deficiency

    Diabetes July 2002 51:2287-2293; doi:10.2337/diabetes.51.7.2287

Epidemiology

    • Babatunji-William Ogunkolade,
    • Barbara J. Boucher,
    • Jean M. Prahl,
    • Stephen A. Bustin,
    • Jacky M. Burrin,
    • Kate Noonan,
    • Bernard V. North,
    • Nassima Mannan,
    • Michael F. McDermott,
    • Hector F. DeLuca,
    • and Graham A. Hitman

    Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians

    Diabetes July 2002 51:2294-2300; doi:10.2337/diabetes.51.7.2294

Genetics

    • Anna Biason-Lauber,
    • Mariarosaria Lang-Muritano,
    • Tindara Vaccaro,
    • and Eugen J. Schoenle

    Loss of Kinase Activity in a Patient With Wolcott-Rallison Syndrome Caused By a Novel Mutation in the EIF2AK3 Gene

    Diabetes July 2002 51:2301-2305; doi:10.2337/diabetes.51.7.2301
    • Claudia Menzaghi,
    • Tonino Ercolino,
    • Rosa Di Paola,
    • Anders H. Berg,
    • James H. Warram,
    • Philipp E. Scherer,
    • Vincenzo Trischitta,
    • and Alessandro Doria

    A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome

    Diabetes July 2002 51:2306-2312; doi:10.2337/diabetes.51.7.2306

Brief Genetics Report

    • Timothy M. Frayling,
    • Andrew T. Hattersley,
    • Anne McCarthy,
    • Jeff Holly,
    • Simon M.S. Mitchell,
    • Anna L. Gloyn,
    • Katharine Owen,
    • David Davies,
    • George Davey Smith,
    • and Yoav Ben-Shlomo

    A Putative Functional Polymorphism in the IGF-I Gene: Association Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations

    Diabetes July 2002 51:2313-2316; doi:10.2337/diabetes.51.7.2313
    • Alan T.W. Choo-Kang,
    • Stephen Lynn,
    • Geoffrey A. Taylor,
    • Mark E. Daly,
    • Sarbpreet S. Sihota,
    • Teressa M. Wardell,
    • Patrick F. Chinnery,
    • Douglass M. Turnbull,
    • and Mark Walker

    Defining the Importance of Mitochondrial Gene Defects in Maternally Inherited Diabetes by Sequencing the Entire Mitochondrial Genome

    Diabetes July 2002 51:2317-2320; doi:10.2337/diabetes.51.7.2317
    • Johan G. Eriksson,
    • Virpi Lindi,
    • Matti Uusitupa,
    • Tom J. Forsén,
    • Markku Laakso,
    • Clive Osmond,
    • and David J.P. Barker

    The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth

    Diabetes July 2002 51:2321-2324; doi:10.2337/diabetes.51.7.2321
    • Hidehiko Kondo,
    • Iichiro Shimomura,
    • Yuko Matsukawa,
    • Masahiro Kumada,
    • Masahiko Takahashi,
    • Morihiro Matsuda,
    • Noriyuki Ouchi,
    • Shinji Kihara,
    • Toshiharu Kawamoto,
    • Satoru Sumitsuji,
    • Tohru Funahashi,
    • and Yuji Matsuzawa

    Association of Adiponectin Mutation With Type 2 Diabetes: A Candidate Gene for the Insulin Resistance Syndrome

    Diabetes July 2002 51:2325-2328; doi:10.2337/diabetes.51.7.2325
    • Anna L. Gloyn,
    • Sian Ellard,
    • Maggie Shepherd,
    • Rodney T. Howell,
    • Elizabeth M. Parry,
    • Andrew Jefferson,
    • Elaine R. Levy,
    • and Andrew T. Hattersley

    Maturity-Onset Diabetes of the Young Caused by a Balanced Translocation Where the 20q12 Break Point Results in Disruption Upstream of the Coding Region of Hepatocyte Nuclear Factor-4α (HNF4A) Gene

    Diabetes July 2002 51:2329-2333; doi:10.2337/diabetes.51.7.2329
    • Abdoreza Davoodi-Semiromi,
    • James J. Yang,
    • and Jin-Xiong She

    IL-12p40 Is Associated With Type 1 Diabetes in Caucasian-American Families

    Diabetes July 2002 51:2334-2336; doi:10.2337/diabetes.51.7.2334
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This Issue

July 2002; 51 (7)
  1. Rapid Publication
  2. Perspectives in Diabetes
  3. Metabolism and Signal Transduction
  4. Obesity Studies
  5. Immunology and Transplantation
  6. Islet Studies
  7. Pathophysiology
  8. Complications
  9. Epidemiology
  10. Genetics
  11. Brief Genetics Report

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