Table of Contents

Perspectives in Diabetes

Select this article
- Leonard A. Fahien and
- Michael J. MacDonald
The Succinate Mechanism of Insulin Release
Diabetes September 2002 51:2669-2676; doi:10.2337/diabetes.51.9.2669

Metabolism and Signal Transduction

Select this article
- John A. Pospisilik,
- Sara G. Stafford,
- Hans-Ulrich Demuth,
- Christopher H.S. McIntosh,
- and Raymond A. Pederson
Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study
Diabetes September 2002 51:2677-2683; doi:10.2337/diabetes.51.9.2677
Select this article
- Kevin Evans,
- Graham C. Burdge,
- Stephen A. Wootton,
- Mo L. Clark,
- and Keith N. Frayn
Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle
Diabetes September 2002 51:2684-2690; doi:10.2337/diabetes.51.9.2684
Select this article
- Marco M. Meyer,
- Klaus Levin,
- Thomas Grimmsmann,
- Nina Perwitz,
- Alexandra Eirich,
- Henning Beck-Nielsen,
- and Harald H. Klein
Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes
Diabetes September 2002 51:2691-2697; doi:10.2337/diabetes.51.9.2691
Select this article
- Kenneth Zierler and
- Reubin Andres
Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased
Diabetes September 2002 51:2698-2702; doi:10.2337/diabetes.51.9.2698
Select this article
- Brian R. Barnes,
- Jeffrey W. Ryder,
- Tatiana L. Steiler,
- Lee G.D. Fryer,
- David Carling,
- and Juleen R. Zierath
Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction
Diabetes September 2002 51:2703-2708; doi:10.2337/diabetes.51.9.2703
Select this article
- Kerrie J. Way,
- Keiji Isshiki,
- Kiyoshi Suzuma,
- Tamotsu Yokota,
- Dmitriy Zvagelsky,
- Frederick J. Schoen,
- George E. Sandusky,
- Penelope A. Pechous,
- Chris J. Vlahos,
- Hisao Wakasaki,
- and George L. King
Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes
Diabetes September 2002 51:2709-2718; doi:10.2337/diabetes.51.9.2709
Select this article
- Daniel Konrad,
- Philip J. Bilan,
- Zafar Nawaz,
- Gary Sweeney,
- Wenyan Niu,
- Zhi Liu,
- Costin N. Antonescu,
- Assaf Rudich,
- and Amira Klip
Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice
Diabetes September 2002 51:2719-2726; doi:10.2337/diabetes.51.9.2719

Obesity Studies

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- Carlo Colombo,
- Jaime J. Cutson,
- Toshimasa Yamauchi,
- Charles Vinson,
- Takashi Kadowaki,
- Oksana Gavrilova,
- and Marc L. Reitman
Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy
Diabetes September 2002 51:2727-2733; doi:10.2337/diabetes.51.9.2727
Select this article
- Hitoshi Nishizawa,
- Iichiro Shimomura,
- Ken Kishida,
- Norikazu Maeda,
- Hiroshi Kuriyama,
- Hiroyuki Nagaretani,
- Morihiro Matsuda,
- Hidehiko Kondo,
- Naoki Furuyama,
- Shinji Kihara,
- Tadashi Nakamura,
- Yoshihiro Tochino,
- Tohru Funahashi,
- and Yuji Matsuzawa
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Diabetes September 2002 51:2734-2741; doi:10.2337/diabetes.51.9.2734
Select this article
- Mikaela Sjöstrand,
- Soffia Gudbjörnsdottir,
- Agneta Holmäng,
- Lars Lönn,
- Lena Strindberg,
- and Peter Lönnroth
Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects
Diabetes September 2002 51:2742-2748; doi:10.2337/diabetes.51.9.2742

Islet Studies

Select this article
- Giovanni Patanè,
- Marcello Anello,
- Salvatore Piro,
- Riccardo Vigneri,
- Francesco Purrello,
- and Agata Maria Rabuazzo
Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition
Diabetes September 2002 51:2749-2756; doi:10.2337/diabetes.51.9.2749
Select this article
- Frank Reimann and
- Fiona M. Gribble
Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells
Diabetes September 2002 51:2757-2763; doi:10.2337/diabetes.51.9.2757
Select this article
- Kyung Soo Kim,
- Yup Kang,
- Sung E. Choi,
- Ju Hee Kim,
- Hyeon Man Kim,
- Beichen Sun,
- Hee-Sook Jun,
- and Ji-Won Yoon
Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes
Diabetes September 2002 51:2764-2772; doi:10.2337/diabetes.51.9.2764
Select this article
- Adama Kamagate,
- André Herchuelz,
- and Françoise Van Eylen
Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells
Diabetes September 2002 51:2773-2788; doi:10.2337/diabetes.51.9.2773
Select this article
- Ann Maria K. Hansen,
- Inge T. Christensen,
- John Bondo Hansen,
- Richard D. Carr,
- Frances M. Ashcroft,
- and Philip Wahl
Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1
Diabetes September 2002 51:2789-2795; doi:10.2337/diabetes.51.9.2789

Pathophysiology

Select this article
- Thomas A. Buchanan,
- Anny H. Xiang,
- Ruth K. Peters,
- Siri L. Kjos,
- Aura Marroquin,
- Jose Goico,
- Cesar Ochoa,
- Sylvia Tan,
- Kathleen Berkowitz,
- Howard N. Hodis,
- and Stanley P. Azen
Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
Diabetes September 2002 51:2796-2803; doi:10.2337/diabetes.51.9.2796

Complications

Select this article
- Yuji Hiramatsu,
- Naotaka Sekiguchi,
- Michio Hayashi,
- Keiji Isshiki,
- Tamotsu Yokota,
- George L. King,
- and Mary R. Loeken
Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy
Diabetes September 2002 51:2804-2810; doi:10.2337/diabetes.51.9.2804
Select this article
- Billy W.H. Chan,
- Kwok-siu Chan,
- Tsuyoshi Koide,
- Sau-man Yeung,
- Maran B.W. Leung,
- Andrew J. Copp,
- Mary R. Loeken,
- Toshihiko Shiroishi,
- and Alisa S.W. Shum
Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid
Diabetes September 2002 51:2811-2816; doi:10.2337/diabetes.51.9.2811
Select this article
- Robert D. Hoeldtke,
- Kimberly D. Bryner,
- Daniel R. McNeill,
- Gerald R. Hobbs,
- Jack E. Riggs,
- Sarah S. Warehime,
- Ian Christie,
- Gary Ganser,
- and Knox Van Dyke
Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes
Diabetes September 2002 51:2817-2825; doi:10.2337/diabetes.51.9.2817
Select this article
- Alan Stitt,
- Thomas A. Gardiner,
- Nathan L. Anderson,
- Paul Canning,
- Norma Frizzell,
- Noel Duffy,
- Cliona Boyle,
- Andrzej S. Januszewski,
- Mark Chachich,
- John W. Baynes,
- and Suzanne R. Thorpe
The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes
Diabetes September 2002 51:2826-2832; doi:10.2337/diabetes.51.9.2826
Select this article
- Ryoji Nagai,
- Yuka Unno,
- Miki Cristina Hayashi,
- Shuichi Masuda,
- Fumitaka Hayase,
- Naohide Kinae,
- and Seikoh Horiuchi
Peroxynitrite Induces Formation of N^ε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite
Diabetes September 2002 51:2833-2839; doi:10.2337/diabetes.51.9.2833
Select this article
- Florence Sabatier,
- Patrice Darmon,
- Benedicte Hugel,
- Valery Combes,
- Marielle Sanmarco,
- Jean-Gabriel Velut,
- Dominique Arnoux,
- Phillipe Charpiot,
- Jean-Marie Freyssinet,
- Charles Oliver,
- Jose Sampol,
- and Francoise Dignat-George
Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles
Diabetes September 2002 51:2840-2845; doi:10.2337/diabetes.51.9.2840
Select this article
- Richard K.M. Wong,
- Andrew I. Pettit,
- Joan E. Davies,
- and Leong L. Ng
Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress
Diabetes September 2002 51:2846-2853; doi:10.2337/diabetes.51.9.2846

Genetics

Select this article
- Otto Tschritter,
- Michael Stumvoll,
- Fausto Machicao,
- Martin Holzwarth,
- Melanie Weisser,
- Elke Maerker,
- Anna Teigeler,
- Hans Häring,
- and Andreas Fritsche
The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia
Diabetes September 2002 51:2854-2860; doi:10.2337/diabetes.51.9.2854
Select this article
- Hua Wang,
- Winston Chu,
- Swapan K. Das,
- Qianfang Ren,
- Sandra J. Hasstedt,
- and Steven C. Elbein
Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians
Diabetes September 2002 51:2861-2865; doi:10.2337/diabetes.51.9.2861

Brief Genetics Report

Select this article
- Gillian C.L. Johnson,
- Felicity Payne,
- Sarah Nutland,
- Helen Stevens,
- Eva Tuomilehto-Wolf,
- Jaakko Tuomilehto,
- and John A. Todd
A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes
Diabetes September 2002 51:2866-2870; doi:10.2337/diabetes.51.9.2866
Select this article
- Lydie Pani,
- Melissa Horal,
- and Mary R. Loeken
Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy
Diabetes September 2002 51:2871-2874; doi:10.2337/diabetes.51.9.2871

Diabetes

Perspectives in Diabetes

The Succinate Mechanism of Insulin Release

Metabolism and Signal Transduction

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased

Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice

Obesity Studies

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

Islet Studies

Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition

Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes

Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

Pathophysiology

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Complications

Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy

Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid

Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

Peroxynitrite Induces Formation of N^ε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress

Genetics

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

Brief Genetics Report

A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes

Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy

This Issue

Current Issue

Diabetes

Table of Contents

Perspectives in Diabetes

The Succinate Mechanism of Insulin Release

Metabolism and Signal Transduction

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased

Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice

Obesity Studies

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

Islet Studies

Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition

Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes

Plasma Membrane Ca2+-ATPase Overexpression Reduces Ca2+ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

Pathophysiology

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Complications

Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy

Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid

Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

Peroxynitrite Induces Formation of Nε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress

Genetics

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

Brief Genetics Report

A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes

Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy

This Issue

Current Issue

Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

Peroxynitrite Induces Formation of N^ε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite